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Drugs May Offer AIDS Prevention
FlipFlopSnowMan writes "There is an interesting article on MSNBC about the possibility of preventing AIDS using the same pills that are currently used to fight the virus in affected individuals." From the article: "The drugs are tenofovir (Viread) and emtricitabine, or FTC (Emtriva), sold in combination as Truvada by Gilead Sciences Inc., a California company best known for inventing Tamiflu, a drug showing promise against bird flu. Unlike vaccines, which work through the immune system -- the very thing HIV destroys -- AIDS drugs simply keep the virus from reproducing. They already are used to prevent infection in health care workers accidentally exposed to HIV, and in babies whose pregnant mothers receive them."
Q. How to make more money from expensive AIDS drugs?
A. Obvious - sell it to people who don't have AIDS as well as people who do.
As I understand, these drugs are very expensive, and personally I can't see any justification for using them prophylactically.
Oh no... it's the future.
"odds are 1 in 10000"...rather 1 in 1000, and even more for receptive sex, and if you do it once a day, you get almost a 1 in 2 chance of catching it after 500 days. Check Chad Douglas on google...always on top, positive after 5 years, dead after 15.
Google passes Turing test : see my journal
Pandemic? Really? Tuberculosis affects far more people worldwide but doesn't have all the sensationalism that we see surrounding AIDS. I don't mean to imply that nothing is being done about TB, or that AIDS isn't a problem, but I'm tired of the media treating this disease like we're all living on the set of "Rent"
How does a 7-person democracy cut a pie? Into 4 pieces.
as an AIDS counsellor, I've worked with many people who are taking these drugs on a daily basis. While they are a brilliant development and have already saved millions of lives, they are EXTREMELY TOXIC; they are totally unsuitable for preventive purposes, apart from being very expensive, they require regular blood tests for specialised medical monitoring (to check your body's responses, get the doses correct, etc), and there are often really grim side effects (such as vomiting, diahoerrea, nausea, fatigue, depression, etc etc); I know many who have chosen to come off the drugs because the quality of their life had got so bad from the side effects that they would rather die with a bit of diginity.
They hammer your immune system; it's like taking poison every day, it's a bit like chemotherapy in ways.. in fact, that's not a bad analogy: why don't we all start on an ongoing course of chemotherapy as a preventive measure against getting cancer?
ps. I'm not an Anonymous Coward, I'm a *Lazy* Anonymous Coward from Ireland
What a bunch of tripe. Michael Moore would be really proud of the first paper. (I didn't read the second one, sorry) I can excuse the writer if 1/2 of the inaccuracies are from an ignorance of the field, but it honestly seems like she's trying to dissuade. Virtually every 3rd paragraph contains and inaccuracy or inappropriate insinuation that is subtle enough to be missed by someone who isn't trained in these fields. The author focuses her arguments by looking at small segments of the literature and history and ignoring the broader sweeps. For example:
The paper's initial assertion is that AIDS was introduced as a polio virus. Simple logical disproof: 1) polio vaccine is given across social/habitual classes. 2) There has not been 1 case of AIDS where the person didn't have one of the following three risk factors: blood transfusion, risky sex*, IV drug use. 3) Not everyone in the US has previous three risk factors. 4) If 2 is true 1 or 3 must be false or at least excruciatingly improbable. 5) 3 is true, therefore 1 must be false. QED. (*risky sex = sexual activity where both partners are not exclusively monogamous to each other at any time during or prior to their relationship)
Several pages deal with the controversy surrounding the initial discovery of the HIV virus. There was also controversy surrounding the discovery of DNA, therefore we shouldn't believe DNA is the 'source code' of life?
She makes light of the microliter aliquots used in the CBC tests but fails to mention that all CBC tests (test which count the types and number of cells in your blood) uses these metrics. We shouldn't trust tests for hundreds of diseases including leukemia, polycythemia, or even iron deficiency based on this implication. (for example, look at the normals on this page: http://www.saintfranciscare.com/11377.cfm)
She also does not respect the validity of the HIV Load test, saying that since it uses PCR (a very common technique in medicine) it cannot be accurate. (no more genetic testing, goodbye cancer diagnosis, goodbye endocrinology) She also asserts that the HIV Load assay will give false-positives and is inaccurate if the procedures are not followed. Yes, it does give false positives, it is a HIGHLY sensitive test, with a low specificity. It is not a screening test, and it cannot be used for one because of its high false positive rate. Additionally, I challenge anyone to find a test in any field that is valid when its procedures are not followed. (magnetism doesn't attract wood, therefore magnetism is false)
http://www.labtestsonline.org/understanding/analyt es/viral_load/test.html
But the coup-de-gras for me was her statistics that showed how low CD4 counts don't correlate to AIDS. (AIDS is, incidentally, practically being defined by low CD4 count)
* "61% of people with CD4 count = 200 in 1997 were AIDS free"
* -response: Yes, CD4=200 is the upper limit at which you see AIDS symptoms, this is expected
* "190,000 Americans in 1993 with CD4 count=200 were AIDS free"
* -response: See above, plus in 1993 the AIDS definition was changing so you see changes in the statistics. Additionally, that number is far less than a quarter of the number of AIDS cases in the US that year. (http://wonder.cdc.gov/wonder/data/aidsPublic.html )
* "No studies have been done to show removal of anti-retrovirals = disease"
* -response: No, but anti-retovirals have been tightly correlated to increased CD4 counts, and their withdrawal to lower CD4 counts. It has also been shown repeatedly (and even in this paper!) that low CD4 count correlates with disease.
The list goes on and on. I just pointed out a few of the most egregious and most easily refuted examples. It just goes to show that if someone really wants to believe someth