Cell Division Reversed for the First Time

SubtleGuest writes "Gary J. Gorbsky, Ph.D., a scientist with the Oklahoma Medical Research Foundation, has found a way to reverse the process of cell division. The discovery could have important implications for the treatment of cancer, birth defects and numerous other diseases and disorders. Gorbsky's findings appear in the April 13 issue of the journal Nature. "No one has gotten the cell cycle to go backwards before now," said Gorbsky. "This shows that certain events in the cell cycle that have long been assumed irreversible may, in fact, be reversible." In the lab, Gorbsky and his OMRF colleagues were able to control the protein responsible for the division process, interrupt and reverse the event, sending duplicate chromosomes back to the center of the original cell, an event once thought impossible. Here is a video of it happening."

Comments

Press Release Promises Flying Cars

[dondelelcaro]

The ability to return a cell to metaphase upon the removal of a chemical (Flavopiridol) which causes the mitotic exit of cells which are expressing non-degredatable Cyclin B is interesting, but it definetly tells us nothing about how to reverse this process in non-transformed human cells. The press release is a bit too effusive about the potential of this finding to radically transform the treatment of cancer, etc. as the finding primarily recomfirms the hypothesis that the degredation of cyclin B is what gives directionality to the cell process, and by blocking the degredation of Cyclin B, you can reverse the cell cycle.

And just in case you're confused like the submitter, there's way more than one protein involved in the cell division process in any eukaryotic cell; Cyclins like Cyclin B are very important, but it's a whole host of proteins that are involved in ushering the cell from G1 to S to G2 to M; assuring alignment, proper exit, arrest upon damage, etc. [One could even argue that the whole point of most cells is to divide, and so every bit of the cell is important and/or participates in some way in the process...]