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Canadian Scientists Regrow Teeth

54mc writes "APL reports that Canadian Scientists have created the first device able to regrow teeth and bones. The researchers at the University of Alberta in Edmonton filed patents earlier this month in the United States for the tool based on low-intensity pulsed ultrasound technology after testing it on a dozen dental patients in Canada."

54 of 220 comments (clear)

  1. Amazing by Anonymous Coward · · Score: 3, Funny

    I didn't believe in the tooth fairy until I saw my dentist in loafers.

    So if you are out there, Mr. Dentist man, you can now officially BITE ME!

  2. Inevitable Discovery by supafly613 · · Score: 4, Funny

    This was a 2 phase discovery:

    Phase 1 - Invent a sport where a piece of equipment that, at times, travels towards your face at 160 km/hour and weighs only 170 grams.

    Phase 2 - Invent a way to grow teeth back due to resulting injury from Phase 1

    It's a Canadian make-work program :)

    --
    - - - "Some people hate the English. I don't. They're just wankers. We, on the other hand, are colonized by wankers."
    1. Re:Inevitable Discovery by lowrydr310 · · Score: 2, Interesting
      I don't understand why people always associate Hockey with missing teeth. For the past 30 years or so goalies have been wearing face shields, nearly eliminating their chances of getting teeth knocked out.

      Players who aren't goalies still don't wear face shields in 2006, however most facial injuries from hockey involve someone getting hit with the end of a stick or getting crushed into the boards by a bad hit, NOT getting hit with a puck (though it does happen sometimes).

    2. Re:Inevitable Discovery by twistedsymphony · · Score: 2, Informative

      I'm not a hockey fan so I don't remember the guys name but There was a famous player way-back-when that lost a few teeth. He became sort of the face of hockey at the time with his toothless grin and thus the stereotype.

    3. Re:Inevitable Discovery by Anonymous Coward · · Score: 3, Informative

      I think you are talking about Bobby Clarke, the current GM of the Flyers. He had one of those great hockey smiles, where you could slide a puck between the gap in his smile. The photo you are thinking of I believe was when the Flyers won the cup in the 70's (he played there before becoming the GM).

      Oh, and it isn't a sterotype. There are very few pro players who haven't lost a few chicklets along the way. Between sticks, pucks, hard hits, solid boards, and fights, about the only players who aren't missing a couple are the goalies. Hard to imagine the goalies only started wearing ANY facial protection in the late fifties, early sixties.

    4. Re:Inevitable Discovery by AppyPappy · · Score: 2, Funny

      Big deal. It's been done. I saw it in a Harry Potter movie. Growing bones is a nasty business.

      --

      If you aren't part of the solution, there is good money to be made prolonging the problem

    5. Re:Inevitable Discovery by crossmr · · Score: 2, Insightful

      it can happen frequently. Darren McCarty got hit in the face twice in the same series against anaheim, during which the anaheim fans booed him as he lay on the ice (thats another story).
      They do take a lot of sticks in the face, and I'm not sure I buy this whole "a visor limits me" thing. I'm sure someone can design a visor that doesn't "limit" them. Were I in the NHL, I wouldn't hesitate to wear a full face mask, especially playing as a defenseman where I'd block a lot of shots.

    6. Re:Inevitable Discovery by Lord+Ender · · Score: 2, Interesting

      Not even the audience is safe in hockey. I was at an NHL game in Columbus a couple years back where a puck hit a girl in the audience. But it didn't just break teeth, it killed her. The players aren't the only ones who get hurt by pucks.

      --
      A slashdotter who didn't build his own computer is like a Jedi who didn't build his own lightsaber.
    7. Re:Inevitable Discovery by cellocgw · · Score: 2, Interesting


      AFAIK where I come from, players are required to have face shields. It seems it's still not mandated in the NHL..

      It's worse than that. The NHL bans full face shields (with exceptions for players recovering from broken cheekbones,jawbones, etc). It's an incredibly stupid rule.

      --
      https://app.box.com/WitthoftResume Code: https://github.com/cellocgw
    8. Re:Inevitable Discovery by rs79 · · Score: 4, Funny

      "I don't understand why people always associate Hockey with missing teeth."

      Uh, because of all the missing teeth?

      This story was front page news in the Globe and Mail (Canada's national newspaper) yesterday a with the headline "new hope for hocky players" (or something like that) and had pictures of vintage and current toothless hocky players.

      --
      Need Mercedes parts ?
    9. Re:Inevitable Discovery by Thuktun · · Score: 2, Informative
  3. So how exactly does it work? by nietsch · · Score: 3, Interesting

    "with low frequency ultrasound pulses" is pretty uninformative for me. If they can regrow theeth, do they first have to implant a 'seed' that will focus the growth? Every theeth has a quite specific form, how will this device influence that?

    Or can it be that somebody patented a possible way to stimulate bone & tooth growth and some reporter let his fantasy run wild on it?

    --
    This space is intentionally staring blankly at you
    1. Re:So how exactly does it work? by goonies · · Score: 3, Insightful

      "with low frequency ultrasound pulses" is pretty uninformative for me.

      ..and pretty much wrong ;-) The article said "low-intensity pulsed ultrasound"
      low frequency ultrasound is like saying: "Thank God, I'm atheist!"
      I think they call it "Contradictio in adjecto" (see also: oxymoron)

      ...and sorry for the nitpicking!

      --
      .sigh
    2. Re:So how exactly does it work? by Red+Flayer · · Score: 2, Funny
      Every theeth has a quite specific form, how will this device influence that?
      (emphasis mine)

      Obviously you have a pressing interest in this cutting-edge technology.
      --
      "Trolls they were, but filled with the evil will of their master: a fell race..." -- J.R.R. Tolkien on Olog-hai
    3. Re:So how exactly does it work? by Massacrifice · · Score: 4, Funny

      No, low frequency ultrasound means they just speak to the jaw gently until they convince it to regrow a new tooth.

      It's the canadian way; american scientists would come to the same results by menacing the offending jawbone with a large-caliber pistol and shouting at it.

      --
      -- Home is where you eat your heart out.
  4. This notice is to inform you... by PixelPirate · · Score: 4, Funny

    This notice hereby notifies you, Tooth Fairy that you are hereby no longer needed as your job has been outsourced to Canada. We hope you will find our severance package of 6 months teeth as well as full dental to be more than generous. Also note that you are hereby banned from acting in the capacity of ortho-collector for a period of 8 years, and any attmpt to circumvent this will lead to a termination of the aforementioned benefits.

    -The Management

    1. Re:This notice is to inform you... by Joebert · · Score: 3, Funny
      This notice hereby notifies you, Tooth Fairy that you are hereby no longer needed as your job has been outsourced to Canada.

      *pssst*
      Think of all the money you could make knocking your own teech out & selling them to the tooth fairy. ;)
      --
      Wanna fight ? Bend over, stick your head up your ass, and fight for air.
  5. Great Test Bed by general+scruff · · Score: 2, Funny

    Lord know Canada is a great place to research tooth replacement, considering that Maine is so close by! We could really use some of that stuff down here!

    Gramps is getting sick of eating through a straw.

    --
    As a rule, I never trust dark brown ketchup.
  6. As a Canadian, I'd like to.. by ABeowulfCluster · · Score: 3, Funny

    .. test this on other body parts. Just sayin.

    1. Re:As a Canadian, I'd like to.. by jamesh · · Score: 2, Funny

      I'm sure it's possible. Which particular bone did you have in mind?

  7. This article has more details by nietsch · · Score: 4, Informative
    --
    This space is intentionally staring blankly at you
  8. Canada has really young scientists by Anonymous Coward · · Score: 4, Funny

    "Canadian Scientists Regrow Teeth"
    A group of Canadian scientists in the age from 4 to 10 has successfully regrown their teeth after they mysteriously lost them.

  9. For Suckers by Joebert · · Score: 3, Funny

    Thee ma ?
    I thold you bruthing your theeth wath fo thuckerth !

    --
    Wanna fight ? Bend over, stick your head up your ass, and fight for air.
  10. Root canal? by paulhar · · Score: 4, Interesting

    > Chen helped create the tiny ultrasound machine that gently massages gums and stimulates tooth growth from the root once inserted into a person's mouth, mounted on braces or a removable plastic crown.

    As several of my teeth have gone the way of the fairy, I wonder how this "treatment" copes with teeth that have been root canal filled.

    And what colour does the new tooth grow back at? It it's pure white - fantastic as it'll put lots of whiting products out of business, but bad as it'll have the pringles effect; once you start you'll have to have all your front/visible teeth done, even if they are just discoloured.

    1. Re:Root canal? by ObsessiveMathsFreak · · Score: 2, Funny

      once you start you'll have to have all your front/visible teeth done, even if they are just discoloured.

      Or you could just, you know, brush them..... Oh wait.

      --
      May the Maths Be with you!
    2. Re:Root canal? by schon · · Score: 2, Informative

      I wonder how this "treatment" copes with teeth that have been root canal filled.

      Saw this on the news last night - they said that it will repair root canals.

      About the only thing it won't do is regrow a tooth that's been removed - it needs cells to start with.

    3. Re:Root canal? by milletre · · Score: 2, Interesting
      >I wonder how this "treatment" copes with teeth that have been root canal filled.

      Saw this on the news last night - they said that it will repair root canals.

      About the only thing it won't do is regrow a tooth that's been removed - it needs cells to start with.

      Sounds pie-in-the-sky at the moment to me. It may be that there is some viable periodontal ligament around necrotic teeth, but there's simply no living tooth-producing tissue in them (odontoblasts). Odontoblasts are found at the pulp-dentin border, which is pretty much removed during cleaning and shaping of the canal space. What they're saying, then, is that they can either bring cells back from the dead (odontoblasts not filed away during root canal therapy), or, using ultrasound only, induce random connective tissue or bone cells into not only reverting to an earlier cell type, but then having it turn into an odontoblast, and then having that odontoblast lay down dentin not on in the quantity they want, but in the direction they want.

      Not bloody likely. I can tell you from experience that teeth with root canals are different animals when it comes to resstoration, fracture susceptibility, extraction, etc.

  11. It makes sense that this comes from Canada... by i_want_you_to_throw_ · · Score: 4, Funny

    What with all those hockey players losing teeth. It was either there or Kentucky where people also don't have teeth. Interestingly that's where the toothbrush was invented. Otherwise it would have been called the teethbrush.

    Thanks, I'll be here all week, enjoy the veal.

    (Disclaimer: I am a Kentuckian)

  12. Medical research is too slow by MichaelSmith · · Score: 2, Interesting

    From TFA:

    With the help of Chen and Ying Tsui, another engineering professor, the initial massive handheld device was shrunk to fit inside a person's mouth.

    But they had something like this working in the late 1990s so for part of the last seven years they have been mucking around making a minature version of their machine. A proper engineering job would have taken six months, max, and they could have kept working on the science.

    Sorry to bitch about this but I see too much improvisation going on and not enough forethought.

    1. Re:Medical research is too slow by Vellmont · · Score: 2, Insightful


      A proper engineering job would have taken six months, max, and they could have kept working on the science.

      You can figure out how long it would take to engineer a device you've just heard of all of 20 minutes ago from a short, non-technical article posted on slashdot?

      --
      AccountKiller
    2. Re:Medical research is too slow by Anonymous Coward · · Score: 4, Funny

      Yes. He's a manager, they can do that.

  13. I won't believe it... by jkrise · · Score: 5, Funny

    until they prove it on these (currently) toothless specimens:
    1. The Justice dept. (SCO vs IBM)
    2. The anti-trust dept. (MS vs US)
    3. Other suggestions welcome...

    --
    If you keep throwing chairs, one day you'll break windows....
  14. What about bones illness? by KarMax · · Score: 5, Interesting
    This is amazing... i never imagine that this could be possible.

    It can also stimulate jawbone growth to fix a person's crooked smile and may eventually allow people to grow taller by stimulating bone growth, Chen said.
    I'm far away to know something about odontology, so i ask to the slashdot doctors:
    This stimulation process could be used to cure bone illness, like Osteoporosis or Osteosarcoma ??

    Thanks in advance.
    --
    Rock and Roll
    1. Re:What about bones illness? by Zzootnik · · Score: 2, Interesting

      Actually, I was more thinking of Using this on Space Travelers to stave off the Bone Density Loss that inevitably (??) occurrs... Sounds like One of the big problems solved...MMmmmmmm... Full Body Ultrasound....

      Or- yeah...I suppose you could also use it to treat/cure degenerative bone loss symptoms. No reason it can't have multiple applications...Except maybe Patent law.

      --
      Sig currently under construction. Mind the gap....
    2. Re:What about bones illness? by Red+Flayer · · Score: 2, Informative

      IANAD (but I do have a Pharmacy degree). But most likely this could not be used to cure osteosarcoma, as stimulating growth of a cancer is probably not the best idea.

      As for osteoporosis, I would suspect stimulating growth is not the right way to go either -- the bones are there, it's the structure of the bone that is weakened. Exercise, calcium intake, Vitamin D intake, and sometimes Fosamax (slows down resorption of calcium) or hormone regimens (still experimental) are the treatments du jour.

      --
      "Trolls they were, but filled with the evil will of their master: a fell race..." -- J.R.R. Tolkien on Olog-hai
  15. Don't need 'em! by PoprocksCk · · Score: 2, Funny

    I don't need no stinkin' "real" teeth. My false teeth are just fine, thank you very much! Hell, I can even eat corn on the cob, if someone cuts it off the cob and then mashes it up into a fine paste!

  16. Just freakin' great. by Khaed · · Score: 5, Funny

    We can grow teeth now. Next step, growing teeth in places not the mouth.

    Now all those nightmares I have about a woman with teeth in her vagina are going to come true.

    Thanks a lot Canada!!

    1. Re:Just freakin' great. by prionic6 · · Score: 4, Funny

      So you have a problem with sticking your genitals into a female body part that has teeth in it?

  17. Re:Tyranny Of Patents by heinousjay · · Score: 4, Insightful

    Fantastic rant. It's logically inconsistent, substitutes opinions for facts, uses examples that don't illustrate your point, and sets up strawmen as its main thrust. Absolutely Slashdottian.

    --
    Slashdot - where whining about luck is the new way to make the world you want.
  18. Horse Hockey! by wdkeeper1 · · Score: 5, Informative

    Horse hockey on the "growing a new tooth" thing, but I can see repairing damaged teeth, depending on the cause of the damage. You need the presence of odontoblasts, etc in order for a new tooth to grow. That guy Chen is an engineer, not a dentist. I'm thinking he doesn't really understand how teeth form and grow, so he's got high hopes for his invention. The root structure of teeth is covered in cementum and dentin, which are repairable, so it makes sense that teeth with root resorption may be fixed by the ultrasonic thing. But to completely grow new teeth, you'd have to have "tooth stem cells" in the area, and those stem cells would have to know what size and shape of tooth to form for that area. I don't see that one happening. I also don't see damaged enamel being fixed by this thing; once enamel is gone, it's pretty much gone.

    1. Re:Horse Hockey! by drunken_boxer777 · · Score: 2, Insightful
      There is no reason to believe that 'tooth stem cells' wouldn't 'know' how to regrow the tooth. In fact, there is sufficient evidence that hypothetical 'tooth stem cells' would 'know' exactly how to regrow the tooth. Research in animals with regenerative capacity in certain tissues/organs has shown that the process of regeneration very closely mimics the process of the initial growth and development of that tissue during embryonic/larval stages. We're talking the same profile of gene expression and protein synthesis.


      Therefore, if your tooth 'knew' how to grow once, it 'knows' how to grow again, given that there are 'tooth stem cells' and that there aren't factors which impede regeneration. (Which there are, in humans and most mammals. The slashdot story from a week or so ago about repairing damaged spinal cords in rats - the researchers used certain reagents which inhibit the inhibitors of regeneration, that's why it worked.)

    2. Re:Horse Hockey! by asuffield · · Score: 4, Informative

      I also don't see damaged enamel being fixed by this thing; once enamel is gone, it's pretty much gone.

      I'm not sure about the rest, but this bit is wrong. Tooth enamel is worn down all the time by your teeth being used, both from abrasion and acidity; this is the normal way they are supposed to work. It is continually replaced by your body, through a chemical process based around your saliva that deposits minerals on the teeth from the outside. So long as the environment in your mouth is not acidic (ie, you haven't been eating sugary food recently) and your diet supplies all the necessary minerals (mostly calcium), fresh enamel will be deposited. Damaged enamel doesn't really need "fixing", you can just let it reform.

      The reason why people tend to think that it can't reform is because the process that grows the teeth in the first place can't be repeated - that deposits enamel in a completely different manner. Also, the reenameling process is quite slow and will only work if you don't snack on sugary things all day.

      The problem is when the tooth is damaged below the level of the enamel; this can't be regrown currently (and prevents the tooth from re-enameling over the top) because the damage from eating progresses faster than the tooth can heal. If the enamel has been worn through completely, damage to the tooth below is inevitable - that's when your dentist drills it out and fills it. If this invention can do something about that, it's a significant step forward.

  19. Regrow Teeth by rocketjam · · Score: 5, Funny

    Thweet!

  20. Re:Presence of stump? by Red+Flayer · · Score: 2, Interesting

    There needs to be a root. Interesting that you bring up the research into teeth grown from stem cells[1], possibly one could create the root from stem cells, implant, and then finish the growth with this device. I'm not sure if tissue rejection would be a problem, though.

    There's also a good potential for this to be used for body modification. Easy enough to add things to the diet to impart a color into the tooth while it grows (one reason why kids aren't given tetracycline -- it makes their growing teeth permanaently orange). A mouthful of glow-in-the-dark teeth? No problem. How about teeth that glow orange or green under a blacklight, instead of violet?

    --
    "Trolls they were, but filled with the evil will of their master: a fell race..." -- J.R.R. Tolkien on Olog-hai
  21. Dr. McCoy would be jealous! by Anonymous Coward · · Score: 2, Interesting

    What's next? All I can say is WOW, I've lost s few teeth from gum disease.

    It isn't nearly as impressive as the technological miracle I've experienced the last 2 days.

    I wore glasses since age 7 (yes I'm a nerd). I switched to contacts 4 years ago, and had to have reading glasses as well as contacts. I used to be four-eyes, now that I'm old it's six eyes.

    Then I got a cataract in my left eye. The specialist told me of a new implant that was only approved in 2003, and extra $1900 above what insurance pays. As it's a one shot deal (they can't remove an implanted artificial lens) I went temporarily broke on it.

    Dr. McCoy would have been jealous of all the technology in the operating room.

    In the recovery room I could read the clock on the wall without any external corrective lenses for the first time in memory (I've worn glasses since 1959). The next day (yesterday) the eye doctor tested my eye, 20-20. For the first time in my life I have no restrictions on my driver's license!

    Last week I had the type on the browser enlarged, plus wore reading glasses. Today I have the type set for normal, and no reading glasses. They tell me in a month I'll be able to read six point type w/o reading glasses!

    In Star Trek II, McCoy gives Kirk a pair of antique reading glasses because he's allergic to the drug that cures age related nearsightedness.

    We're still 200 years from the 23rd century, but we've passed Star Trek tech. Even McCoy didn't have these implants at his disposal! The implant I got, called a Crystal Lens, cures nearsightedness, farsightedness (both age-related and youth myopia), cataracts, and even astigmatism!

    I'll get the other eye done in a few years. Then maybe I'll get some Canadian teeth!

    (anti-MRC="botched". Couldn't be more wrong!)

  22. Dental technology by foniksonik · · Score: 5, Interesting

    I've complained before and will again, that dentistry has been the most underwhelming of 'sciences' for the past 100 years. What advances have we seen since the use of anaesthetics to reduce the pain? We got ultra-violet whitening systems.... and veneers.

    So finally there's some progress. First was the company in florida which has since sort of gone into hiding... they showed a solution of genetically engineered oral bacteria that would take over control of the mouth by out-competing the native breed.. but were engineered to not create cavities. Haven't heard much on that front recently though. Maybe they got bought up by the makers of Crest or something...

    Now we have a device that can regrow eroded tooth material... well it's something at least.

    Maybe I can stop thinking of the whole practice of drilling and gouging and filling in with metals as the most barbaric so-called treatments of any human health problem. Dentistry is still at the equivalent stage of just cutting off the leg when it's broken, rather than fixing it. Hopefully that is about to change.

    --
    A fool throws a stone into a well and a thousand sages can not remove it.
  23. Gullibility of the Slashdot community by osgeek · · Score: 2, Insightful

    I'm curious... when you folks read an article like this, do you automatically believe it?

    Personally, when I see "filed for a patent earlier this month", "testing it on a dozen patients", and "commercialization in two years" -- coupled with a science-fiction-like technology -- I think "BULLSHIT".

    Just add it to the list of other bullshit vaporware impractical/impossible inventions that show up every once in a while trying to grab funding/sucker dollars: holographic memory, ridiculous compression technologies, flying cars, perpetual motion machines, etc.

    I find it pretty amazing that almost all of the responses in this thread just assume that these guys are telling the truth about their "discovery". I'd love to be proven wrong. I'd love to see a new miraculous bone and tooth growing technology be discovered... but scientific and religious claims are easy to make. It's easy to put out a press release. It's hard to prove miraculous things. It's hard to provide evidence for the seemingly-unbelievable.

  24. Wow by blackbeaktux · · Score: 2, Funny

    Innovative and creative approach, and it looks promising. Looks like this one has teeth.

    crickets.chirp()

  25. And In Related News by Petersko · · Score: 3, Funny

    The American Dental Association has called upon the Canadian Government to put an end to the regrowth of teeth, claiming that the availability of cheap teeth from Canada makes American dentists less interested in improving their techniques.

    Said an A.D.A. spokesperson, "We need prices to remain high so that we can afford to innovate. When people can just get new teeth cheaply by just crossing the border, our strangle-ho.... uh, revenue stream will be jeopardized. The U.S. government must act immediately!"

  26. Better Link, Article from Globe & Mail (Canada by geerbox · · Score: 3, Informative
  27. So... by irrelevant · · Score: 3, Funny

    Can the device be controlled via BlueTooth?

  28. Not new exactly by TimmyDee · · Score: 3, Informative

    A few years ago, I broke both bones in my forearm -- the radius was broken so badly that I had pulverized a small portion of it so the two parts didn't line up exactly. They didn't notice this in the x-rays (and so couldn't cut into my hip as they hadn't gotten my authorization for that), so they tried artifical (read: cadaver) bone to regrow the spot. Didn't work.

    A few months later, they enrolled me in a trial of a similar sort of ultrasonic technology by which my bone should regrow. They had been getting a 94% success rate with fibias, but the arm was something new. Needless to say, I was one of those lucky minorities that didn't show any growth. Months later, I was back on the table with new bone being brought in from my hip. Six weeks after that, I was healed. While cool, there is certainly no replacement for real bone.

    --
    Per Square Mile, a blog about density
  29. Re:The Door Into Summer by Catbeller · · Score: 2, Insightful

    Sure, Lazarus Long mentions rebudding teeth as a part of a long list of antigeria techniques used at the Howard Clinics in "Time Enough For Love".

    But even he would say it was an obvious step. We've been needing this for as long as there've been people... BUT KUDOS for you, sir, for remembering science fiction didn't start on television and movies. Or anime.

    There's treasure in the golden age of science fiction. A lot more imagination than displayed in current "sci-fi", which is to science fiction as Hostess cupcakes are to food. Thinking about it, the readers of golden-age SF went on to build moonships. Current sci-fi readers have a hard time thinking about driving electric cars. Difference of breadth of imagination.

  30. Skeptibility of osgeek by 2nd+Post! · · Score: 2, Informative

    How about the fact that published papers have shown, since at least 1996, that ultrasound can accelerate bone growth.

    If it can accelerate bone growth, it seems a logical enough step for someone to experiement with teeth, and given that it's been ten years since bone growth was seen, why is teeth/jaw regeneration so hard to believe?

    Or is it just because you haven't heard of it, it can't be real?

    Did you also know that light acts simultaneously as both a particle and a wave, depending on how you examine it?