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New Alzheimer's Drug Shows Promise
An anonymous reader writes "The Herald Sun is reporting that researchers may have some progress to report on the Alzheimer's front. A new drug, called PBT2, was developed by a Melbourne-based biotech firm that has been showing some promising results. From the article: 'Early clinical testing has confirmed the drug is fast-acting. Levels of amyloid dropped by 60 per cent within 24 hours of a single dose. It found also that PBT2 suppresses the impairment of memory function. More human studies begin in Sweden next month and Australians will join a major international trial of the drug next year.'"
"The Herald Sun is reporting that researchers may have some progress to report on the Alzheimer's front. Maybe. They can't exactly remember one way or the other..."
The Herald Sun is reporting that researchers may have some progress to report on the Alzheimer's front. A new drug, called PBT2, was developed by a Melbourne-based biotech firm that has been showing some promising results.
Fantastic. Now they just have to remember to take it.
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From the article: 'Early clinical testing has confirmed the drug is fast-acting. Levels of amyloid dropped by 60 per cent within 24 hours of a single dose. It found also that PBT2 suppresses the impairment of memory function.
;-)
The article seems to be wrong - press releases on the Prana Biotechnology website indicate these results are from studies in mice.
More human studies begin in Sweden next month and Australians will join a major international trial of the drug next year.
If the data is from mice, then the above clinical trial is presumably a phase I clinical trial, which is designed to show safety and not efficacy. It could be a while before human data is available.
Of course, none of this will stop investors believing the article
"Because it's there." - George Mallory, when asked why he wanted to climb Mt Everest, March 18, 1923 (New York Times)
If this drug is found to actually work, and proceeds to be available for general use within the next five years, it would be a major reversal of the trends we're seeing at the moment. I work in a nursing home designed and built in the 70's, when nursing homes tended to be the place you stayed briefly before dying. Now with our medical advances, together with the high level of day to day care, individually tailored diets etc, we're dealing with people who are living longer. This means we're now running into problems with alzheimers, excarberated by the cocktail of drugs administered. Effectively we're now running into trouble trying to keep people with high level dementia in unsuited facillities. The possibility of an effective treatment for alzheimers makes me wonder if we might be going to move back to the older situation, with lives limited by health again.
[clever sig]
It's interesting but not (yet) as significant as TFA makes out.
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These are studies on transgenic mice, so it's more a proof-of-concept rather than clinical trials which will be some way off - mostly due to bureaucracy.
For those who want a quick *scientific-ish* summary:
It is widely believed that a protein called Beta-Amyloid is reponsible synaptic dysfunction in Altzheimer's disease. Another variant (Alpha-Amyloid) also does horrible things to the body such as renal failure and constrictive pericarditis. This often happens as a result of certain auto-immune diseases (which is my speciality).
These tests are based on the accidental discovery that a dysentry drug (PBT-1) has some effects on restoring some cognitive function in patients. The company pursuing this has created a drug which is more specifically targeted towards reducing levels of A-A. And... so far, so good. The mice show greatly reduced A-A levels and they perform better in mazes. I wish them all the best - Altzheimers is a horrible and frightening disease.
For those who would like a fuller summary in non newspaper-speak, try http://www.medicalnewstoday.com/medicalnews.php?n
Living through your parent's early onset (at 50 years) Alzheimer's really takes egde off any humour of this story. Personally, I welcome these news, there are too few of them. Unfortunately, this drug would come too late for my father, who has now been living with this for 15 years (he really takes his time to do things properly, even dying). New drugs would also offer some hope for relatives, since A is also hereditary to at least some extent.
Brothers, our time has come. This is the secret weapon that will allow our final victory over The Old People! With this technology in our hands, they will be our slaves. They will mine our ore and harvest our lumber to have access to our precious Alzheimers medicine. The Groundor has become the Groundee. He who controls the spice, er, meds, controls the universe!