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Cancer Therapy with Radioactive Scorpion Venom
BostonBTS writes "Researchers from TransMolecular, Inc. have used chlorotoxin -- a component of giant yellow scorpion venom -- to target radioactive treatments for the deadly brain cancer glioma. From the article: 'In the study, 18 patients first had surgery to remove malignant gliomas, a lethal kind of brain tumor. Then doctors injected their brains with a solution of radioactive iodine and TM-601, the synthetic protein. The solution bound almost exclusively to leftover tumor cells, suggesting that it could be combined with chemotherapy to fight cancer. Furthermore, two study patients were still alive nearly three years after the treatment.' Their paper is slated for publication in the August issue of the Journal of Clinical Oncology."
RTFA:
Before you die, you see DoubleRing...
Says the guy with "godgab" as his god damned signature.
Un-fucking-believable.
-Peter
I'm not sure that answers the question. Many die within months, but we're talking about only 2 out of 18 to make it three years. Curves have tails, and knowing that the mean is only a few months doesn't tell us how many would be expected to live for 3 years.
The Journal of Neuroscience (google cache, the site appears to be down) says that "more than half die within 18 months". Presumably that's with standard treatment. If half were to die every 18 months, that would still leave 1/4 of the patients, around 4, after two years.
I'm sure that's not the right curve to draw; Wikipedia says "few patients survive beyond three years". Is "few" more or less than 2 out of 18? Probably less, but I'm still not at all clear on whether this treatment is actually better than the standard treatment.
So why are people fighting over land in that part of the world?
They want the part that isn't infested with 4-inch long yellow scorpions.
I hereby place the above post in the public domain.
The problem with the "standard treatment" is it usually involves surgery. The Glial cells are the support and structure cells for the actual brain cells. To the naked eye, the cancerous cells (Glioma) are undistinguishable from normal cells (like sugar and salt mixed in a bowl - for multiforme), though an MRI can differentiate.
Any surgery also removes healthy Glial and brain cells (which do not regenerate) and the patient's functionality degrades. All it takes is one remaining Glioma cell and the process starts again.
Some people cannot, or choose not to, have surgery. As I posted earlier, my wife died in January of a GBM, just 7 weeks after diagnosis. She declined as it was next to her brain stem and would have left her completely paralyzed on her left side and blind in the left side of each eye. Surgery may have prolonged her life a bit, but it wouldn't have been the life she loved.
Hopefully, treatments like this will reduce the need for surgery at some point.
It must have been something you assimilated. . . .
Howdy,
e r/Sontheimer.htm). Glioblastoma is hypothesized to be so deadly because of the
ability of cancer cells inside the brain to quickly migrate from the primary site to other sites within the brain, quickly invading normal
brain tissue. This makes surgery or radiation not very effective, since migrating cells may be hidden within normal brain that is not
irradiated or cut out. The migratory ability of glioblastoma cells is related to its unique ability to change size and morphology to
move in between normal brain cells.
The effectiveness of chlorotoxin in treatment of glioblastomas was discovered by a scientist here at my institution (http://www.neurobiology.uab.edu/Faculty/Sontheim
The size-changing migratory ability is related to a specific chloride ion channel that expresses highly and uniquely on certain brain cancer cells, including gliomas (PubMed ID: 8804043, 8967454). Chlorotoxin, a chloride channel inhibitor discovered in 1993 (PubMed ID: 8383429) was more interestingly found to bind to this glioma-specific chloride ion channel in mice in 1998 (PubMed ID: 9809993) and humans in 2002 (PubMed ID: 12112367). Although it was shown that chlorotoxin failed to inhibit migratory ability due to size-change, chlorotoxin was shown to inhibit migration by inhibition of another protein involved in breaking down the extracellular matrix, allowing cells to more easily migrate.
The strategy that TransMolecular uses to treat gliomas lies in the specificity of expression of the channel to which chlorotoxin binds. That channel is expressed on the vast majority of glioma tissue samples tested, and only rarely on normal tissue. If one attaches a weak or short-lasting radioactive moiety to chlorotoxin, a potential treatment can be to target glioma cells using chlorotoxin, and then kill them by short-lasting localized radiation. This strategy is already being used in Non Hodgkins Lymphoma and other diseases by attaching to tumor- targeting antibodies a radioactive iodine atom.