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Genetically Engineered Machines Competition

Posted by ryuzaki0 on from the birth-of-synthetic-biology dept.

aqkiva writes, "This past weekend, 33 schools from around the world gathered at MIT for the international genetically engineered machine competition. Teams consisting of mostly undergraduates had designed, built, tested, and characterized biological parts, devices, and systems over the course of the summer and came together to present their work. The competition is helping push the field of synthetic biology and opening access to the tools to engineer biological systems by providing standard biological components. The team from Slovenia won first prize overall for their engineering of mammalian systems and won the 'BioBrick,' a large metal Lego brick. The MIT team won the top prize for the best system with their engineering of bacteria that smell like wintergreen and banana. For news coverage of this weekend's jamboree, see the Boston Globe and Technology Review."

22 of 38 comments (clear)

  1. Smells like... by Apocalypse111 · · Score: 1

    ...bacteria that smell like wintergreen and banana

    Ok, so how long until we can get this stuff to feed on various waste products? I know I'd much rather have my cat's farts smell like wintergreen than, well, cat poop.

    --
    There is no mod option "-1: Disagree" for a reason. "Overrated" is not an acceptable substitute. Post something instead.
    1. Re:Smells like... by gardyloo · · Score: 2, Funny

      I know I'd much rather have my cat's farts smell like wintergreen than, well, cat poop.

            Thanks a bloody lot. I've just suddenly started thinking about that gum I swallowed yesterday.

    2. Re:Smells like... by Stanistani · · Score: 1

      No, no...

      Biggest market = Mouthwash that lasts all day because it GROWS IN YOUR MOUTH!

      --
      You can't talk about Wikipedia's flaws on Wikipedia
    3. Re:Smells like... by Stripsurge · · Score: 1

      *Stephen Hawking voice* You're idea of wintergreen cat feces intrigues me. Perhaps I will steal it */voice*

      In all seriousness it wouldn't be hard to do. Take gut bacteria and insert the genes in the wintergreen (Methyl salicylate) pathway. I suspect though the natural flora of the large intestine would outcompete the introduced variety. The two types would be the same except one wastes energy on a useless, and harmful product. Methyl salicylate is similar to salicylic acid, neither of which should be injested.

      Banana smelling feces might be a better choice. Isoamyl acetate is the ester produced. I'm not sure how much of the stuff would have to be made to ensure a nice smell. Also I have no idea at what rate it'd be consumed in the gut by other organisms. You might have to buy special food laced with bacterial spores that continually boost the levels of the special bacteria. Interesting idea.

    4. Re:Smells like... by vfp_guru · · Score: 1

      But, once this becomes common, who would ever want to eat bananas (or breath mints) again!?

    5. Re:Smells like... by reverseengineer · · Score: 1
      The process the MIT team used to create pleasant-smelling bacteria is pretty interesting, and might address your comment about (ahem) cat farts. They started with a strain of E. coli that had indole production genes knocked out. This is important to note, because the chemical indole and its derivatives have very strong odors. In trace quantities, it is a component of many pleasantly scented oils, like oil of jasmine.

      In larger concentrations, indoles smell like feces. In fact, feces usually smell like feces because they contain indoles- 3-methylindole, for instance, also goes by the name skatole, as in "scat," for good reason. Indoles are produced in the breakdown of many natural products in the body, most notably the amino acid tryptophan and its derivatives like serotonin (coincidentally, while E. coli has a well-studied system called the trp operon for making tryptophan, we lack this, so tryptophan must be obtained from the diet). So step one in making something smell good is getting rid of processes that smell bad.

      As far as the production of nice smells like wintergreen and banana, those two smells might stand out to anyone who had an organic chemistry lab course- Fischer esterification being a very popular experiment for novices. The nice smelling chemicals, methyl salicylate and isoamyl acetate (more of a pear smell, IMO) are esters, combinations of an organic acid and an alcohol (acetyl salicyate is aspirin, btw). Organic chemists use a reaction catalyzed by acid or base and heat; biology uses enzymes called transferases to do the same job. The genetic engineering that the MIT team did is here- the salicylate methyltransferase comes from a petunia hybrid, for instance, and the alcohol acetyltransferase from Saccharomyces cervesiae, a.k.a. brewer's yeast (there are some good beers out there that have a fruit odor to them, despite containing no fruit- this is how). They also had to insert a bunch of genes to allow E. coli to make precursors it would have been unable to otherwise, like salicylic acid, and others to regulate the process. The MIT team has a page covering the major elements of their "toolbox" here.

      --
      "FDA staff reviewers expressed concern about the number of patients who were left out of the study because they died."
  2. Re:BioBrick by diersing · · Score: 1

    In your imagination was Bender standing when the BioBrick falls between his legs?

  3. Now *this* is Intelligent Design by Colin+Smith · · Score: 1

    Finally there's a reason for including the term in the science curriculum, I'm sure the religious nuts will be whooping in the aisles.

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    Deleted
  4. the blob! by roken123 · · Score: 1

    Just what we need, a real life: "The Attack of the Blob: The Science Experiment Gone wrong".

    1. Re:the blob! by k12linux · · Score: 1

      But at least it will smell good!

      "What's that smell? OMG, RUN!"

  5. Oh? Let me know. by krell · · Score: 1

    Genetically-engineered machine pageant? Ah. Just make sure to let me know when Number 6 shows up for the swimsuit competition segment.

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    Where were you when the voynix came?
  6. First Robotics by purduephotog · · Score: 1

    Sounds alot like the FIRST robotics program. Our company (ITT) has sponsored a team the last 3 years, but may not this year because they claim there is no money available. We'll see- lots of fundraising is available.

    Given that this competition has quite a bit more lead time, I think you'd get much better results then the 4 week/6 week build time. Any program that brings the bright and talented, as well as the dedicated and interested in to work together in a competitive environment is a plus- we'll need those next generation engineers to come from somewhere.

    (And I'm passing on the joke about 3 of the machines mating and producing a super death killer cyborg because I figure others will make it for me...)

  7. Re:BioBrick? by LindseyJ · · Score: 1
    I'm guessing you just decided to stop reading after that comma.

    ...a large metal Lego brick.
  8. Re:BioBrick by Anonymous Coward · · Score: 1, Interesting

    "The Registry of Standard Biological Parts is a collection of parts: sequences of DNA with specific function that can be combined together to implement more complex functions. These parts are called BioBricks."

    http://syntheticbiology.org/BioBricks.html

  9. Re:BioBrick? by Anonymous Coward · · Score: 1, Informative

    Thanks for your enlightning hint, but i wanted to know what a "BioBrick" normally is:
    http://syntheticbiology.org/BioBricks.html
    http://openwetware.org/wiki/BioBricks_construction _tutorial

  10. Re:It's not that I'm a n00b, but.... by gwayne · · Score: 1

    Duh, morning breath will smell like wintergreen and farts will smell like bananas!

  11. Not good. by Phate89 · · Score: 1

    We are getting closer to the day of the terminator >

    --
    Man is least himself when he talks in his own person. Give him a mask, and he will tell you the truth
  12. Re:It's not that I'm a n00b, but.... by k12linux · · Score: 1

    Awesome living clothes that change color and shape at your whim (ala UltraViolet) and consume sweat and dead skin... get infected with a virus and eat you in your sleep after numbing your nerves so you don't know it's happening until too late?

  13. Re:It's not that I'm a n00b, but.... by kc8tbe · · Score: 1

    Someone with the technology to engineer a virus to cause your living clothes to numb your nerve endings and eat you in your sleep could just engineer a virus to kill you directly.

    And don't think that such a virus could arise spontaneously. It's astronomically more likely that a naturally arising virus would simply cause your bio-clothing to rot. And possible smell like bananas and wintergreen in the process.

  14. Cool stuff! by SQFreak · · Score: 1

    This is all really cool stuff. I'll admit, I'm biased. I go to a school that competed in iGEM, I'm good friends with a student team member, and I work for one of the faculty members on our iGEM team. My school's team modified E. coli bacteria to solve the burnt pancake problem. It's essentially a biological computer, albeit extremely specialized.

    My ultimate point is that you shouldn't dismiss this stuff as useless or without practical application. Understand that the technology is just in its infancy, and that with time, genetically engineered machines and their products will probably be more that we could ever guess now.

  15. Re:It's not that I'm a n00b, but.... by k12linux · · Score: 1

    Presumably the living clothes wouldn't have a complex immune system to protect it.

    "bananas and wintergreen" - lol

  16. Hurrah Slovenia! by vrykolaka · · Score: 1

    For those who dont know, Slovenia is the northernmost part of Ex-Yugoslavia, and Thomas Jefferson got inspiration from the rules of old Slovenia (Caranthania) when writing the Constitution.

    Another Slovene team recently created a nanoparticles detector for Europes NanoSafe2 (French link).

    Back to topic: Slovenes are very hard-working but tend to depreciate themselves. Don't judge a book by the cover.

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    -- Force & respect, Vrykolaka