Scientists Find New Painkiller From Saliva
dptalia writes "Scientists have found a new pain killer based on human saliva. Apparently 1 gram of the new drug provides as much pain blocking as 3 grams of morphine. The drug blocks the breakdown of the body's natural pain killing mechanism. Scientists say the molecule is simple and synthesis is expected to be simple."
They isolated a peptide which inhibits two enzymes that chew up enkephalins, the body's natural pain killers. Inhibiting these makes the naturally-released enkephalins hang around longer. The problem is that peptide drugs have a checkered history. See the article linked below.
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http://www.pnas.org/cgi/content/abstract/06058651
If Slashdot were chemistry it would look like this:Cadaverine
BBC got it right: http://news.bbc.co.uk/2/hi/health/6142842.stm
It's because the salvia can't get inside the tooth, where your pain is. You should try drilling a hole in it, so the salvia can reach the pain...
They didn't inject 3g of morphine in a human.
They didn't even inject 3g of morphine in a rat.
What they found was that 3 grams of morphine per kg body weight is about as potent as 1 gram of morphine per kg body weight of the new saliva substance.
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