Super-Vaccine For Flu In Development

Adam9 tipped us to a DailyMail article about the possibility of a revolutionary flu vaccine that could work against all strains of the Influenza A disease. This 'holy grail' of vaccines would work on everything from the annual 'winter flu' to the 'bird flu'. The best part is that just a few vaccinations may provide complete immunity, unlike the annual boosters are current defenses require. From the article: "The new jabs would be grown in huge vats of bacterial 'soup', with just two pints of liquid providing 10,000 doses of vaccine. Current flu vaccines focus on two proteins on the surface of the virus. However, these constantly mutate in a bid to fool the immune system, making it impossible for vaccine manufacturers to keep up with the creation of each new strain. The universal vaccines focus on a different protein called M2, which has barely changed during the last 100 years."

Comments

unchanged protein

[javilon]

"The universal vaccines focus on a different protein called M2, which has barely changed during the last 100 years."

I bet it will change in the next 5 years...

Do fix-alls really exist?

[dada21]

I was contemplating vaccines and software patches and other items that constantly need updating and never really solve the problem and came up with a theory of selling reality -- do you ever want to sell a product that never needs updating or repairs or replacement? Is it anyone's goal to truly fix a problem forever?

One of my businesses is IT consulting, and we really do try to fix our customers problems for good -- when possible. We find that solving problems today ends up giving us more work tomorrow through referrals, etc. We even have a popular warranty where we always fix things that break again for free (even if we lose money on the net), even due to user error. Yet most consultants love the repeat business -- why fix something forever if you're sure that only temporarily patching a problem is enough?

Are there any vaccines or medical products that really do anything permanent? Is part of the reason for temporary cures or fixes just the basic realistic knowledge that temporary cures mean job security?

I don't trust anything that is sold as a "permanent fix" for a problem -- I don't know if we humans are capable of doing anything so self-sacrificial as that.

Re:Do fix-alls really exist?

[Watson Ladd]

Do you see smallpox around anymore?

Re:Do fix-alls really exist?

[sgt.greywar]

Are there vaccines or medical products that are permanent? Are you serious here? Maybe just googling for vaccines would help you out here. Had polio recently? Whooping cough? Rubella? Hepatitus? Is having a shot once a decade "too often" since it is only "temporary"? Geez sorry medical breakthroughs that are equivalent to miracles aren't convenient enough for you.

Great News - but why emphasise stockpiling?

[giafly]

Described as the 'holy grail' of flu vaccines, it would protect against all strains of influenza A - the virus behind both bird flu and the nastiest outbreaks of winter flu. .... Importantly, the vaccines would also be quicker and easier to make than the traditional jabs, meaning vast quantities could be stockpiled against a global outbreak of bird flu.

If the vaccine protects against all strains of influenza A, why stockpile it? Surely just vaccinating people would be simpler and protect them immediately. There are several mentions of stockpiling, so I really wonder whether this article is accurate.

Re:Great News - but why emphasise stockpiling?

[MightyYar]

Probably because it would be hard to compel people to get the vaccine. I mean, there is a vaccine available now for this year's flu, yet I sit here un-vaccinated. Hell, I doubt that my tetanus shot is up-to-date. People only get vaccinated when they are scared - my infant is vaccinated, my wife is vaccinated (she's in health care), and many old folks get vaccinated. The rest of us just take our chances with the flu because we aren't scared of it and we don't get it every year.

When something is more deadly, people get vaccinated. Everyone will be in line for an AIDS vaccine, and they certainly have no trouble getting folks vaccinated in the US against polio or smallpox.

You'll never "stop" the flu as they have with smallpox and polio (almost), because it jumps species too easily. If birds still carry it, it will be very difficult to control in human populations.

Is a cure enough?

[EmbeddedJanitor]

Having a cure is not enough to prevent the disease from happening. A concerted effort to suply the vaccine is also needed.

Smallpox etc seems to have been handled pretty well, yet TB - a totally curable disease - still kills more people than 'flu.

Re:Is a cure enough?

[DrYak]

TB is bacterial

...and is therefore a little bit easier to cure, since we've had antibiotics for a longer time than anti-viral drugs, and since anti-viral drugs tend to be much more bug-specific than antibiotics.

and has no vaccine.

Guess what ? I *happen* to be vaccinated against TB. There are vaccine against TB. It isn't as widely used in the USA is it was in eastern country in the past or still today in Africa. The main reason that it is less used in the western world is that TB isn't very prevalent, and therefor, TB vaccine is only given to people at risk.
(A less important reason is also aesthetic : adults and older children may have a small permanent scar at the point of injection).

Most of the patients are either drug users and/or have compromised immune systems (e.g. AIDS).

In the western world. The largest part of the patient are in third world countries. The TB is prevalent there because of poorer population and harder access to medication, lower quality of life, etc...

Worse, the cure is a 6-9 month course of antibiotics.

...which is on of the reason that TB is prevalent in the 3rd world and that there, vaccine is simpler and cheaper.

I think that TB would largely go along with it in the developed world.

No, as long as there is still a source were the bacteria can proliferate they'll still be there around and still find ways to travel back to your home. There are lot of disease that are clearly under control - with both vaccine and treatment available - but that are still not extinct, because they can proliferate in some animal population (not even in another human population living somewhere else).

The main reasons why there's still TB around are mainly the economic situation in counrties where it's prevalent.
(then there also some other smaller reason like the fact that the bacteria can hide in cavities where they're less accessible to drugs, and also they can stay dormant for a long time).

Re:Is a cure enough?

[Anonymous Coward]

quote\ The main reason that it is less used in the western world is that TB isn't very prevalent, and therefor, TB vaccine is only given to people at risk.

Wrong in the western world TB is considered to be in a crisis stage. It is very prevalent in the USA population(when compared to other modernized countries. Now maybe they don't give out the vaccine to every is mostly because if your rich you get vaccinated when traveling but the poor don't. It is a economic type thing. Keep the poor sick. So money well not be amassed into their hands.

Re:Is a cure enough?

[MightyYar]

I don't think that this is a conspiracy against the poor. In the US, most of the cases of TB are in immigrants who entered the country with latent TB. Those with latent TB have a 10% chance of developing active TB. Most of the other cases arise in prison populations, homeless shelters, and nursing homes.

Your local health department will give you all of the antibiotics you want for free if you have TB... just ask. I know because my wife works in health care, and she got infected, and we used the free antibiotics. It is in no one's best interest to allow TB to flourish.

Re:Eugenics

[ArcherB]

Hooray for making large portions of the population immune to virii with this protein. Nothing like guiding evolution/adaptation ever closer towards pandemic.

You're right! We should ban all medicines that fight diseases that kill millions because they might cause the disease to mutate into a disease that kills millions.

Super Flu?

[Lord_Dweomer]

Correct me if I'm wrong...but isn't the reason that we haven't cured the flu yet with all of our advances in medical technology due to the fact that the virus keeps mutating and evolving due to natural selection taking place when we apply vaccines? Won't this just serve to create a super flu? I really hope that the people doing this research (who obviously know quite a bit more on the subject) have already thought of this...

Re:Indeed!

[Tim C]

They even serialised The Protocols of the Elders of Zion.

I don't read The Daily Hate, and while I'm (clearly!) biased I think it depends on how they serialised it. If the nature of the text was made clear, and it was being presented so as to better critique it, then that's fine.

Given that it's the Hate, though, I doubt if it was done like that...

They aren't there to be a news source. They are there to entertain and scare the masses.

No, they're there to make money, through advertising and sales. The way they do that is by pandering to the lowest common denominator and especially the mob mentality, hence all of the self-righteous campaigning and muck slinging, celebrity gossip, and so on.

None of the tabloids are worth the paper they're printed on, imho; at best they're insipid. Don't forget, though, that most (all?) of the broadsheets have either switched to a tabloid (physical) format, or produce editions in both formats. Don't dismiss a paper based solely on its size and shape...