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GM Mosquito Could Fight Malaria

qw0ntum writes "The BBC is reporting that a genetically modified (GM) variety of mosquitoes could be effective in combating the spread of malaria to humans. These GM insects carry a gene that prevents them from being infected by the malaria parasite and has the added benefit of providing a fitness advantage to the mosquitoes. From the article: 'In the laboratory, equal numbers of genetically modified and ordinary wild-type mosquitoes were allowed to feed on malaria-infected mice. As they reproduced, more of the GM, or transgenic, mosquitoes survived. According to the researchers, whose results appear in Proceedings of the National Academy of Sciences journal, after nine generations, 70% of the insects belonged to the malaria-resistant strain. [...] The modified mosquitoes had a higher survival rate and laid more eggs.' This has major implications for the billions of people living in areas with endemic malaria. The question in my mind, though, is what effects on the ecosystems of these areas will replacing an organism low on the food chain with a GM version? Between the news we saw last week and biomagnification, could this wind up substituting one problem for another?"

13 of 281 comments (clear)

  1. Great, just great by Ctrl-Z · · Score: 5, Insightful

    This is exactly what we need: mosquitoes that are more likely to survive longer. Now I need to go buy a better bug spray. Thanks, science!

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    www.timcoleman.com is a total waste of your time. Never go there.
    1. Re:Great, just great by Arthur+B. · · Score: 3, Insightful

      ... what if... what if we don't do anything an people die from Malaria. You are trading off a sure gain over very hypothetical risks. Why is that? Why this bias for the status quo? What if the current mosquitoes are currently evolving to be better carriers of the West Nile and this will stop them... what if birds feeding on those mosquitoes don't get the bird flue? I doesn't make less or more sense than your scares. The point is, there is NOT necessary less risk in "not doing something" than in "doing something". Of course we can study those mosquitoes for years while people are dying of malaria, sure.

      Oh, this kind of "scare", "precautionary principle" actually led to DDT being banned in the world, while it had almost crushed malaria in Africa.

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      \u262D = \u5350
  2. Building a better mosquito by coolmoose25 · · Score: 4, Insightful

    Who would have thought that we would build a better mosquito rather than continuing to try and control/eradicate them. I am concerned about unintended consequences, but this is fundamentally a new approach to modifying our environment... rather than trying to kill them off and ending up hurting food chains, we just "tweak" them to keep millions of people from dying from them...

    I think it is a good thing.

    //now, let the killer bee comparison commence

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    Brawndo: It's what plants crave!
  3. Setting up for disaster by RingDev · · Score: 5, Insightful

    This is a really risky move. Sure, the mosquitoes are now immune to Malaria and will no longer carry it. But what if this immunity protects them from some other virus that is capable of surviving in the mosquito for longer? Now you have suddenly increased the mosquito population, made it harder to kill the population and made them carriers for some new pathogen that may be just as deadly as Malaria. Genetically modifying something that low on the food change can and will have dramatic effects on the rest of the environment. Why would we run that risk for a problem that can be handled through immunization and treatment? Sure, medical coverage sucks ass in the jungle, but things could get a lot worse if the new mosquitoes carry a new problem into all of the local villages.

    -Rick

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    "Most people in the U.S. wouldn't know they live in a tyrannical state if it walked up and grabbed their junk." - MyFirs
    1. Re:Setting up for disaster by Alioth · · Score: 3, Insightful

      The mosquito isn't the actual problem - the problem is if you create sufficient selective pressure against the malaria parasite, eventually you'll get malaria parasites resistant to the gene in these mosquitos and will be back at square 1 again.

    2. Re:Setting up for disaster by RingDev · · Score: 5, Insightful

      Even if you completely rule out any possibility of a new, or mutated virus/disease that may occur due to lack of competition of resources, you still have the numerous other mosquito borne diseases that will be on the rise due to the increase in mosquito population. Yellow Fever, West Nile, Encephalitis, and a hand full of other wonderful ailments would not be effect by the alteration, but would be effected by the increase in population.

      -Rick

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      "Most people in the U.S. wouldn't know they live in a tyrannical state if it walked up and grabbed their junk." - MyFirs
    3. Re:Setting up for disaster by inviolet · · Score: 4, Insightful

      Why would we run that risk for a problem that can be handled through immunization and treatment?

      Malaria isn't feasible to handle through immunization and treatment, because malaria occurs in wet, nasty, remote, impoverished, quarrelsome places. You may now argue that such problems can be handled with a sufficient application of dumptruck loads of money, but again, the dumptruck loads of money are not interested in being applied to those areas of the world.

      Indeed, malaria has probably killed more humans than anything else in history. And now you sound like Marie Antoinette -- "Let them get treatment!"

      The unintended consequences of these GM mosquitoes would have to be severe in order to outweigh such a colossal improvement in lifespan and quality-of-life as this would bring to all the unfashionable places in the world.

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      FATMOUSE + YOU = FATMOUSE
    4. Re:Setting up for disaster by Tatarize · · Score: 4, Insightful

      I disagree. I'll take that crap shoot. Under box number 1, you have a solution to a problem which kills millions upon millions of people. Under the mystery box you have perhaps nothing.

      Honestly, I don't think the FUD is warranted. Oddly enough though, I thought of this same solution several years ago. Seemed like a pretty good thing to do. Just fix the genes and improve the bug and you have yourself a solution after a few years. I wonder if the religious right will get pissed that people are solving the world's problems using natural selection.

      In theory the carrying capacity should be stable in the mosquito population (not suddenly over-run with bugs). Really all the improvement seems to do is make those mosquitoes immune to the parasite. So the new gene protects the mosquito and by proxy us. Basically they would be introducing a new gene into the population rather than a new bug. This improved gene should increase in frequency and as a result destroy the population of Malaria.

      The article is wrong that the mosquito need compete better even in a malaria free environment. Why the hell would that be the case? We should only care about them in the malaria environment. In fact, it would be the best if they competed worse in areas without malaria. That way the gene population would drop very low when Malaria does. When the gene solves the problem, having it die out would be the best solution.

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      It is no longer uncommon to be uncommon.
  4. A good thing? depends.... by CodeShark · · Score: 4, Insightful
    Okay, so they have a malaria resistant mosquito, and if there were no other effect of the GM, it seems like releasing the beastie to the environment would be a good thing as it substitutes a "less bad biter" for a "known bad biter" it the food chain and implicitly lowers the malarial infection rates.


    My question is "what about the other major mosquito-transmitted illnesses carried by the same type(s)? AKA yellow fever, west nile, etc.?" as I assume there is a limit to how many disease vectors could be prevented by this technique without introducing unintended and perhaps unstoppable effects later on.

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    ...Open Source isn't the only answer -- but it's almost always a better value than the alternatives...
  5. Re:Huh? by solevita · · Score: 3, Insightful

    It's not as if controlling Malaria is an expensive or unknown problem.
    On that point you're very wrong. Sure, for Westerners its easy to travel to malaria ridden areas and not be affected; I recently spent a month in east Africa and spent well over £100 making sure I didn't get malaria. Unfortunately these drugs are horrendously expensive; for some places £100 could be ten years wages for somebody, or even an entire family. Spending £100 in a month is absolutely unimaginable.

    Malaria kills millions of people each year. You're wrong, present methods of controlling malaria are expensive and unknown for the people that actually require them. I'm not sure that GM is the way to go, but I'm sure that something needs to be done, not for us holiday makers, but for those people that live in areas where malaria is rampant and the average wage is practically nothing a day.

    And I'm a little worried that someone modded you as funny.
  6. Re:Not Quite ... by Daniel_Staal · · Score: 3, Insightful

    That depends on the strain of malaria contracted, and even then it is in dispute. (It is hard to tell if certain froms of malaria are cured or just dormant without removing your liver and dissecting it...)

    This would do more than just prevent it, though: It has the potential to erradicate it: Malaria only spreads via mosquitos, and it needs a certain 'resident infected population' to remain viable in an area. If a large enough percentage of mosquitos don't transmit it, less people will be infected, and the desease could just die out from being unable to spread.

    From what I see they are being careful: testing in contained environments the new mosquitos' reaction to various situations. This could be a very good thing...

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    'Sensible' is a curse word.
  7. Re:Just use DDT by Garse+Janacek · · Score: 4, Insightful

    Why do we have to create mutant mosquitos when we can use good old DDT? All we have to do is get rich, white people to get off their high horses at cocktail parties so the rest of the world can be saved from this horrible disease.

    Wow, you paint an impressive caricature of anyone who could possibly disagree with you. However, your suggested solution (and the accompanying ad hominem) is just as simplistic as the opposing view that DDT is an unmitigated evil.

    For someone who is not rich, white and at a cocktail party and yet still disagrees with you, I'd point to my wife, who is Nigerian and, like most of her family, has actually had malaria. She still thinks unrestrained use of DDT is a bad idea -- partly because, though much of Silent Spring was discredited, it is still a toxin that builds up substantially over the very long term, and it's a good idea to avoid that if you don't know the effects over the course of a lifetime, but especially because of the point that other responses have made, that if we did that then soon DDT would become useless, even in cases where we really did need it.

    It would clearly be a stupid idea to recommend that every human being continuously take antibiotics. It is a similarly bad idea to say that entire ecosystems should be covered with DDT. Right now, use of DDT in moderation can handle particularly bad infestations. Heavy DDT use would lower malaria rates for a few years, before bringing it back up above todays levels because there would be no easy fix at all.

    Your caricature of rich white people on high horses perpetuating disease among the poor and powerless is only at all legitimate if you yourself are not also essentially an armchair philosopher on this issue. If you are insulting other people for having opinions on how to effectively protect people, because they have no personal stake and are somewhat removed from the issue, then you'd better have some personal stake or be close to the issue before going on about your own opinions on the issue. Obviously I don't know your personal stake, if any -- but a lot of people who seem to feel the way you do are no closer to the issue than your hypothetical rich white people.

    It would also be good to accept that people who oppose heavy DDT use are genuinely trying to protect people's lives, and have reasons for their opinions (even if you disagree with them), and it's not just that all of them freaked out after reading Silent Spring.

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    I am the man with no sig!

  8. Re:Huh? by solevita · · Score: 4, Insightful

    Quinine is not expensive.
    I love your assertion that all those people that have spent their entire lives and billions of billions of whatever currency you want to mention, missed something that you, random guy off Slashdot, knew all along.

    I'm no expert in this sort of thing by any stretch of the imagination, but if it was all as easy and as cheap as you say, don't you think someone else would have also come up with the same idea?

    I can just see some research scientist checking the front page of /. before making a phone call: "Sorry sir, it was all a waste of time, we should of stuck with Quinine all along. I've got plenty of it here, bring the Gin and meet me in my office after lunch".