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Scientists Re-grow Dental Enamel

A reader at Cloning Resources writes "Dental enamel is the hardest tissue produced by the body. It cannot regenerate itself, because it is formed by a layer of cells that is lost by the time the tooth appears in the mouth. The enamel spends the remainder of its lifetime vulnerable to wear, damage, and decay. In hopes of eventually replacing teeth, scientists from Japan have developed a new method for growing dental enamel."

15 of 60 comments (clear)

  1. A long way to go by zeropointburn · · Score: 4, Interesting

    Like all genetic regrowth techniques, this one has a long way to go before it could be used in humans. At present, it involves using pig cells incubated in the abdominal tissue of living rats. Fascinating, to be sure, but not quite mainstream yet.
    It is interesting that this group is using collagen sponges as scaffolding; I'm glad to hear research has continued with that technique to the point that it is functional for growing complex tissues.
    This is certainly promising; the step from here to fully-regrown teeth is not overwhelming. Still, I wouldn't bet on your Coca-Cola stocks skyrocketing just yet.

    --
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    1. Re:A long way to go by jamesh · · Score: 3, Funny

      At present, it involves using pig cells incubated in the abdominal tissue of living rats

      Hmmmm... for some reason I am reminded of haggis...
    2. Re:A long way to go by Rob+T+Firefly · · Score: 2, Funny

      On the other hand, haggis will probably be one of the few foods that can overpower the intrinsic taste of teeth made from piggy cells basted in rat guts.

    3. Re:A long way to go by Almost-Retired · · Score: 2, Interesting

      Well now, to speed up their research, lets recommend that they advertise for people like me, who had this regenerative ability to regrow teeth from the gitgo, and do research on them to find out how they did it?

      Does anyone know how to contact these people?

      Taking advantage of that in humans would seem to show a way to shortcut all this animal experimentation. I could do this for about the first 40 years of my life. The growth didn't seem to be as hard as it could have been, but broken teeth were not a problem in my earlier years.

      I once had the 2 front teeth of both upper and lower jaws removed by a wrench wielded by a jealous former husband of my first wife, and who looked a lot worse that that when I was done. A year later you couldn't tell they had ever been broken off at the gum line. Full height and worn sharp again in a year. Sweet...

      The net result was that while I did get cavities, they were often migrated up the side of the tooth and worn off the top without ever having any dental intervention other than an occasional routine cleaning. A dentist doing research on this 50 years ago tells me that the percentage of people like me runs about 2 per 100k, so he was glad to see me because it gave him a chance to do xrays (gratis to me) that recorded this phenomenon. But just like a woman going from man to man, I went from job to job and we lost geographic track of each other. Now of course I'm getting the fillings touched up at yearly intervals, and have been for 30 years. But, it damned sure was nice while it lasted!

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  2. Very promising by Looce · · Score: 2, Interesting

    This is a godsend for those people who grit their teeth involuntarily at night, like my father. The enamel on his teeth is most likely all gone already. (And those people who are nervous before exams in school and grit their teeth, etc.)

    And, who knows, we might even be able to avoid filling teeth in the future; just apply/create some enamel in a cavity after burning the bacteria, neutralising the acid and stuff like that.

  3. On the other side of the coin... by jamesh · · Score: 2, Insightful

    ... I was thinking as I was having my wisdom teeth removed that it would be nice if it could be possible to artificially trigger the same response that causes the 'baby' teeth to fall out, maybe by injecting something in the root to cause it to disolve. Much less blood, pain, and (potential) nerve damage.

    1. Re:On the other side of the coin... by Alicat1194 · · Score: 3, Interesting

      As far as I know, baby teeth don't so much fall out, as they are pushed out by the adult teeth growing up from below (I used to work with a girl who still had some of her baby teeth, as for some reason she never grew adult teeth to replace them)

      --
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  4. But I thought this was already being worked on? by stephencrane · · Score: 5, Interesting


    There was an article last year about someone coming up with using ultrasonic waves to trigger regrowth of teeth.

    http://www.sciencedaily.com/releases/2006/06/06062 8234304.htm

    This seems much more along, and less complicated. I imagine a new use for an ultrasonic transducer is easier to get approved than transgenic tissue grafting.

    I really wish there was some central repository of active studies, with an easy way to grade their progress and potential oversight burden. I imagine being able to subscribe to studies and experiments, and receiving updates when available. The most irritating thing about 'scientific discovery' news articles is the fickle nature of the media to keep people in the loop on it. Whenever a bold claim is made, it becomes news. But the incremental progress is not sexy, so you never hear of it again. How many 'promising' cures for various cancers have we heard of, only to never heard of them again?

    1. Re:But I thought this was already being worked on? by TeknoHog · · Score: 2, Informative

      There was an article last year about someone coming up with using ultrasonic waves to trigger regrowth of teeth.

      AFAIK, it uses a rather well-known effect for stimulating bone growth, the same by which e.g. running makes your leg bones stronger. The article mentions uses related to the jaw and the roots of teeth, both of which are basically bone. On the other hand, enamel is a completely different tissue that cannot regenerate in adults because the cells are no longer around, as explained in the main article.

      --
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  5. Re:Takes A Swig From My 2 Liter by Anonymous+Brave+Guy · · Score: 3, Informative

    The most recent studies most definitely do show that people who daily have a high intake of sugar through drinks like soda have a higher risk of developing type 2 diabetes.

    Perhaps you'd care to cite those studies, then?

    You might care to pass them on to the American Diabetes Association and Diabetes UK, both of which seem pretty clear that we're talking about a myth here. A quick Google will also turn up several recent research papers that do not show the link you assert.

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  6. Re:This is cool. by shambalagoon · · Score: 2, Funny

    Their teeth would just keep getting bigger.. and bigger..

  7. Tongue/mouth piercings by quokkapox · · Score: 2, Interesting

    That is the really sad thing about tongue piercings and mouth piercings that nobody tells you about before you get them.

    Unless they're properly sized, your teeth will get worn and chipped. I chipped a molar a week after I had my tongue pierced.

    Regarding the technique in the article, I think a better solution for many people is to figure out how to stimulate the growth of completely new teeth in adults, yank 'em all, and have all new ones grow in place. Especially if you can decide to omit extra molars the second time around for people with smaller mouths.

    --
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  8. baby teeth resorb by bill_mcgonigle · · Score: 2, Interesting
    As far as I know, baby teeth don't so much fall out, as they are pushed out by the adult teeth growing up from below

    Sort of. The pressure from the adult teeth cause the roots of the baby teeth to dissolve. A baby tooth falling out doesn't look like an extracted tooth - the root is almost gone by time it falls out.

    Let's see Wikipedia must have something on this.... ah, here:

    The erupting permanent teeth causes root resorption, where the permanent teeth push down on the roots of the deciduous teeth causing the roots to be dissolved and become absorbed by the forming permanent teeth.

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  9. Cool but nasty by J05H · · Score: 3, Interesting

    They propagated the cell-sponge matrix inside rat's abdomens. And they want that in your mouth? Ick. Biotech has a strong gross-out factor sometimes. They put dead people's bones in living people and use cow bone for reconstruction? Are we becoming vampires in a hi-tech manner?

    Josh

    --
    gigantino.tv - Heavy but weighs nothing.
  10. Re:Woohoo for the rich! by Eric+Smith · · Score: 2, Insightful

    It's not my fault that you have no dental care, nor is it the fault of the researchers. I'd say that it's most likely the fault of insurance companies and the US Congress. My complaint with Congress is that they allow businesses to write off the cost of providing health insurance for their employees, but they do not allow individuals who are not covered by an employer's plan to write off the cost of buying the insurance themselves. It is unconscionable that Congress should give this "perk" to businesses and not to individuals.

    Although I currently have health insurance that covers dental care, I have at times in the past had to pay for dental care out of my own pocket. And at those times, I was still glad that there were people doing research to improve the state of the art of dental care.