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Cancer Fighting Drug Found in Dirt

firesquirt writes "From an article in LiveScience, the bark of certain yew trees can yield a medicine that fights cancer. Now scientists find the dirt that yew trees grow in can supply the drug as well, suggesting a new way to commercially harvest the medicine."

30 of 184 comments (clear)

  1. Next headline... by wbren · · Score: 5, Funny

    "Pharmaceutical company patents dirt; Critics claim prior art"

    --
    -William Brendel
    1. Re:Next headline... by delire · · Score: 3, Interesting

      Your joke points to a sad reality however, that it's only through patenting cures (ie having a monopoly over a cure) can pharmaceutical companies (free enterprises) get the investment capital to develop medicines. Cures are IP, traded and guarded.

      Moreso, the last thing any pharmaceutical monopoly can afford is for people to get better very easily. For this reason cures are highly guarded discoveries: there are many cures around we don't have access to, and perhaps never will, either because they threaten an existing sickness market or because the IP pushes the price up beyond our reach. Just because we hear about a cure doesn't mean we'll ever see that cure in the wild. Expand this grim fact 100 fold in places like Africa or India where the cost of IP literally comes between them and surviving an otherwise perfectly cureable disease (if only production and distribution were the only cost).

      In many respects sickness itself is a managed resource and pharaceutical patents - as a monopoly of a cure - are an active ingredient in this logic.

    2. Re:Next headline... by WallaceAndGromit · · Score: 2, Funny

      ... 8 year old sued for telling friend to eat dirt.

      --
      Name: Mr. Anon E Mouse; SSN: 555-55-5555
    3. Re:Next headline... by bunratty · · Score: 4, Insightful

      For this reason cures are highly guarded discoveries: there are many cures around we don't have access to, and perhaps never will, either because they threaten an existing sickness market or because the IP pushes the price up beyond our reach. Just because we hear about a cure doesn't mean we'll ever see that cure in the wild
      Surely there are researchers involved in finding these hidden cures you refer to. Why don't any of them blow the whistle on this massive conspiracy?
      --
      What a fool believes, he sees, no wise man has the power to reason away.
    4. Re:Next headline... by delire · · Score: 2, Informative

      Why don't any of them blow the whistle on this massive conspiracy?
      Because it's not a consipiracy. It's good common sense capitalism.
    5. Re:Next headline... by LurkerXXX · · Score: 5, Insightful

      Take off the tinfoil hat. I'm a medical researcher. If I discover a cure for a disease, I get famous in my field, guaranteed funding, and get invited to speak at research Universities around the world. Maybe even win a Nobel prize. It's all pluses. What do I get to keep it secret if I'm a researcher? Nada.

      Uninformed conspiracy nuts seem to think Pharm companies do all the medical research. The NIH (National Institutes of Health) will spend more than 28+ Billion on medical research this year (your tax dollars at work). I do research funded by them. My work is all published in journals you are free to subscribe to, or browse for free at your local research university's library.

    6. Re:Next headline... by LurkerXXX · · Score: 4, Insightful

      I assure you, being in the field and being involved in the patent process, I am much better versed on the topic than you. Thanks for the offer to look around, but I've already done it. A lot. I do it for a living.

      There is no grand conspiracy as you would have others believe to keep cures hidden. As I said, NIH does most of the basic research for exploring biology and finding new drugs. Pharm companies do some drug exploration, but the bulk of their research dollars are spent on clinical trials which are *extremely* expensive. Many times there are candidate drugs which don't go on to clinical trials. These are not 'hidden'. Anyone is free to look at the literature to see them. And many researchers I know who have published new exciting results, try to get a story in the more general public news. This gets their name out there, and the Institute/University they work at gets some press that they love. Once again, not hidden. No conspiracy.

      Patents are an entirely different issue. Patents are public record. Once again, they aren't hidden from you. Drugs generally have a use patent, so it's easy to see exactly what disease they are for the treatment of. Nothing hidden. Also patents don't last forever. Anyone with a patented drug that works will try to sell it like made for several years, because the patent is going to expire, and then anyone will be able to make a generic version of it, with no patent worries.

      If the company patented a drug and sits on it because they don't think they will recoup as much as it would cost to do the trials/manufacturing, well, the patent is still going to expire, so others will be able to use it then. Nothing hidden again. No conspiracy.

      Now, if the original company didn't want to go through the expense of doing clinical trials for it because they didn't think they would recoup their money, no one else is likely to want to foot the bill entirely either, since when they get it passed, all their competitors are then free to manufacture generic versions as well.

      It all boils down to clinical trials, and who pays for the huge expense of them. No one wants to foot the bill for unpatentable or patent-expired drugs because it's 100+ million down hole for the company doing the trials, and a free ride for all their competitors. It's just terrible business sense. No 'conspiracy' involved at all.

      Put away the tinfoil hats. It comes down to simple business decisions a 12-year old should be able to grasp. Blaming pharm companies and academic researchers for 'conspiring' to keep them off the shelf is simply stupid.

      If you want a better system for orphan drugs, then lobby your congressmen to expand NIH funding to include drug trials for orphan drugs. Public dollars would be well worth spending in that area.

  2. In the greater scheme of things... by mudshark · · Score: 4, Funny

    ... it's not all about yew, after all. It's the dirt from whence yew came, and where yew shall ultimately return....

    --
    In other news, astrophysicists have announced that they now know what all that dark matter is: it's stupidity.
    1. Re:In the greater scheme of things... by mrogers · · Score: 3, Funny

      You're barking up the wrong tree.

    2. Re:In the greater scheme of things... by sharkey · · Score: 2, Funny

      Is this Dr. Land Fill?

      "It's not about yew!!! You need to get right, and read my latest book: 'I Made Dirt, My Dirt Don't Hurt'".

      --

      --
      "Outlook not so good." That magic 8-ball knows everything! I'll ask about Exchange Server next.
  3. Time and time again... by Anonymous Coward · · Score: 4, Insightful

    ...we discover these things that the Earth provides us, and yet we learn nothing of protecting it from ourselves.

    Silly monkeys.

    1. Re:Time and time again... by Anonymous Coward · · Score: 2, Insightful

      Fuck Earth. Take your tree-loving sacrificial rain-dance bullshit back to whatever liberal leaf-licking college you barely crawled tripping off LSD out of with your "degree". We really don't need this tripe. Do you honestly think us "silly monkeys" would have even made a discovery such as this without technology built by a society powered by the very resources you likely eschew? Sure, we've found yet another cancer fighting drug (which is a pretty insubstantial claim, go hit up Google for "cancer fighting drugs" and you'll find a laughable number of such claims in the past decade) in some dirt. This does little more than provide us with a step in the right direction, perhaps a clue towards something that will, in all likelihood, (and this is making the bold assumption that this discovery will build to anything at all besides some bright-eyed scientist's footnote on slashdot.org) be completely artificial in its synthesis.

      You're an unscientific babbling Slashtard; I'm amazed at how fast you people creep out of the fucking woodworks to preach your gospel and screed to us. You're rated insightful when you deserve a completely off-topic and even flamebait moderation. You're not talking about the study, you're not talking about the nature of the findings that were reported, you're just shitting all over this discussion with your ignorant cut-throat idealistic diatribe about how stupid we are. Fuck.

      Surely your like-minded goons will hop to your aid to hush me, moderating me down and nodding me off as "just a conservative whacko", but I speak for many with "shut the fuck up". If you're such an idealist, go live in a cave and stop promoting the ecosystem-damaging resource consumerism that yes, even your using this computer whose case is likely comprised of many plastics and synthesized oil by-products is promoting. The epic volume of clothes barely covering your gargantuan Slashdotter body? Yep, you guessed it, something you're wearing is likely synthesized as a by-product of crude oil! This preachy shit is getting you nowhere, buddy. Either contribute to the discussion or leave. Don't worry, us silly monkeys will stick around and do the heavy thinking.

      Now, back to your regularly scheduled discussion.

    2. Re:Time and time again... by Skrynesaver · · Score: 4, Informative
      This is not an alternative to anything, this is a chemical which can be found in yew bark. Do you consider Asprin an alternative remedy? it can be harvested from willow bark after all. As yew is a highly toxic plant I don't recommend chewing on it in the hope of a cure, similarly the concentration of salicylic acid in willow bark is variable and chewing on willow bark will give you ulcers as a result.

      Bayer managed to patent not Asprin itself but the process of synthesising it. As I don't believe you can patent discoveries even in the US.

      --
      "Linux is for noobs"-The new MS fud strategy
  4. Here we go again by El+Lobo · · Score: 5, Insightful

    I HATE when people and even pseudoscientific articles talk about a medicine against "cancer". Hell, there is NO cancer. There are CANCERS. Lung cancer has a completly different nature than, say, bllod cancer, ot colon cancer, or skin cancer. Yes, all of them are chaotic grow of the cells, but their nature, symptoms, erradication and even cell behaviour is completly different. It's therefore naive to talk about a "cure for cancer". It's like saying: a drug against virus has been found. Hell! WHAT virus? They are all different!

    --
    It's time to realise that Abble's products are the biggest abomination these days. Just say NO to the dumb iAbble way!!
    1. Re:Here we go again by VirusEqualsVeryYes · · Score: 4, Interesting

      But do most people know about these differences? Hell, I'll admit that even I have no idea what you're talking about. All I know is that mutations in cells's DNA can cause them to replicate uncontrollably, hence cancer. There are differences in lung/blod/colon/skin cancer? Sounds plausible! ... but I have no idea what they are. To me, and to most normal people, "cancer" encompasses all cancers.

      I guess it's like saying a certain finding advances "science". But wait, you say, there are a lot of sciences! Yes, there are, and the finding most likely only really advances one of the sciences ... and yet, we all understand what is meant when we say something advances "science".

    2. Re:Here we go again by krotkruton · · Score: 4, Insightful

      I don't think people are really that ignorant about the disease. Ask someone for one of the causes of skin cancer and you'll probably get "too much sun without sunscreen", or ask for one for lung cancer and you'll get "cigarette smoke". I think most people understand that there are many different types of cancer that can all be caused by different things, but I don't know if they understand that a cure for one might not be a cure for all, if that was even the initial point of this thread. On the other hand, someone may very well find a single cure for all forms of cancer, in which case, is it really wrong to call it a cure for cancer?

    3. Re:Here we go again by pointbeing · · Score: 2, Informative

      But do most people know about these differences? Hell, I'll admit that even I have no idea what you're talking about. All I know is that mutations in cells's DNA can cause them to replicate uncontrollably, hence cancer. There are differences in lung/blod/colon/skin cancer? Sounds plausible! ... but I have no idea what they are. To me, and to most normal people, "cancer" encompasses all cancers.

      A common misconception. Cancer is a catch-all term for more than 100 diseases that display similar characteristics - the ability to mask itself from the host immune system, angiogenesis and some cell replication tricks that normal cells can't pull off.

      The spousal unit has been undergoing treatment for Stage IV breast cancer for almost eight years - it had already metastasized to her lungs by the time she was diagnosed. Breast cancer in your lungs is still breast cancer and at least as far as medical oncology (as opposed to radiation or surgical oncology) is concerned the treatment is the same.

      My father-in-law was treated with a drug called Gemzar for pancreatic cancer a couple of years ago. My wife just finished up Gemzar + Herceptin before we started the current Tykerb + Xeloda regime. Gemzar is first-line chemotherapy for pancreatic cancer but is only indicated in breast cancer after an anthracycline and a taxane have been tried and determined they were ineffective. The Xeloda she's doing now is on the bottom of the breast cancer treatment list but is first line treatment for Stage IV colon cancer.

      Different diseases, different treatment.

      --
      we see things not as as they are, but as we are.
      -- anais nin
  5. And you though RMS was just a smelly hippie by Timesprout · · Score: 2, Funny

    When it turns out he is a shower dodger to avoid cancer.

    --
    Do not try to read the dupe, thats impossible. Instead, only try to realize the truth
    What truth?
    There is no dupe
  6. Wow by Tawg · · Score: 4, Funny

    Now this is what i call a cancer Treetment.

  7. Pacific Yew by Tawg · · Score: 3, Interesting

    It's quite interesting to note that one of the species of yew mentioned (i assume the most useful at yielding the drug) has been classified as NT (Near threatened).
    This basically means the species is "considered threatened with extinction in the near future". With such a large area of yew trees producing such a small amount of drug, careful measures are going to have to be taken so as not to kill off our new hope for a cancer cure. It's also quite interesting to note that the yew only grows to about 15metres, and so much smaller than what i would know as a (european) yew tree.

  8. So much for our parents telling us not to eat dirt by Antony-Kyre · · Score: 2, Insightful

    So much for our parents telling us not to eat dirt as kids.

  9. Cancer Fighting Drug Found in Dirt by Rik+Sweeney · · Score: 4, Funny

    *tch*

    The things people throw away these days...

  10. It isn't a new medicine just a new way to get it by MSRedfox · · Score: 3, Informative

    The headline makes it sound like a new wonder drug was found. According to the article, this drug was found in 1967. So it's been around for quite a while. They've just found that the soil around the trees end up with the drug in it to. Thus when they harvest the drug, they can harvest the soil to get more of it at one time. Nothing new cure wise, just a better way for drug companies to produce a product.

  11. It's a good drug by Anonymous Coward · · Score: 2, Informative

    I was one of the guinea-pigs that tested it. It worked incredibly well, better than the alternative at the time which hadn't worked for me leaving me with a choice of taking part in the experiment or trying a large dose of the other medicine with little chance of success.

    I'd heard at the time that it was becoming viable because they'd found a way of synthesising it using chemicals extracted from the needles of the tree, so reducing the impact on the tree. If they can get hold of it with less impact on the tree then that's great!

    As a point to all those people who think of "natural remedies" as harmless and western medicine as evil: I was treated with yew tree bark and some fungus. These two nearly killed me even in the precisely controlled doses, doses that had been determined through the deaths of some thousand or so rats rather than trial and error on some thousand or so humans. Now many thousands of humans can be saved from what is quite a nasty death thanks to this new treatment.

    Natural remedies are just the same as any other item taken into the body. They can be good, or can cause harm. Unfortunately in this case, animal experiments did work very well and in my opinion have caused net good.

  12. Hopefully by chanrobi · · Score: 2, Funny

    It'll be dirt cheap for those who need it

  13. It's not the tree - it's the microbes by csoto · · Score: 4, Interesting

    Most people forget that all higher organisms depend heavily on micribiota for their survival. For example, most of the complex micronutrients (e.g. B-comlplex vitamins) in plants are generated in soil bacteria. For these drugs, look to the rhizobacteria as the source of the genes for these compounds. The commensal relationships these bacteria sustain with particular plant species could be important, but it's possible these things could be grown in vitro and yield a nice industrial solution.

    --
    There exists no way of exchanging information without making judgments. --Bene Gesserit Axiom
  14. Barking mad by ciaran.mchale · · Score: 2, Funny

    So it seems those new age, tree-hugging hippies weren't "barking" mad after all. They "yew" what they were doing all along. And I guess that, as far as pharmaceutical companies are concerned, money does grow on trees after all. Hey, that's "tree" of a kind so far. I'd better stop now and see if I can afford a mortgage on a tree house.

  15. Well, there's a new one... by Khyber · · Score: 3, Funny

    Let the strip-mining operations to cure cancer begin!

    --
    Still waiting on Serviscope_minor to wake up to fucking reality and realize that Jessica Price isn't going to fuck him.
  16. Bah, it just goes to show by 50000BTU_barbecue · · Score: 2, Funny

    Yews control the medecine market.

    --
    Mostly random stuff.
  17. Re:Next headline...The tinfoil is not all wrong by LurkerXXX · · Score: 2, Insightful

    Ok, I'm going to be silly and feed the anonymous troll...

    Mostly, I agree with you; but, there are cases where the "tinfoil hat" IS the business decision that the twelve-year-old can grasp:

    "Cure vs treatment". The profit motive (by itself) would far rather sell a treatment than a cure.


    So they are hiding the cures because they want to sell a treatment? Who is hiding it? Who discovered it that has that motive? As I said before, NIH dollars fund the most basic research which leads to new biology/drugs. Pharma does a little of that, but most of their dollars go into the clinical trials. So the academic researcher working for NIH funds has *ZERO* motive to hide the cure. *ZERO*.

    So your tin-foil-hat theory rests on the key discovery being made by smaller amount of primary research being done in Pharma companies. Who do you think does the research, runs the bench experiments, crunches the numbers in those Pharma companies? Is it the high-end management who stands to make a killing from corporate profits? No. It's done be Ph.D. scientists and lab techs. A decent sized group of them.

    Do you honestly think someone lab tech with a B.S. biology degree is going to be paid enough money to shut up about some great disease cure that is found by their group?

    How about the Ph.D.'s in the group? Earning a Ph.D. is a long long haul. Most folks doing that are pretty smart and could have made much more money going to business school if making money was their number one priority. Most scientists care about knowledge, care about cures, and yes, like the prestige and recognition for making a major discovery. How likely is it they are going to keep a disease cure secret so the top management can get big bonuses? Not very freaking likely.

    Even if some would do it, all it would take is one in the group to leak it. Keeping secrets in groups just doesn't work very well. Now stop to think what if a friend/family-member/loved-one of a member group has the disease? Not that unlikely with any decent sized lab group. Still think they are going to keep a cure secret? Please.

    But as an example, consider the minor ailment athlete's foot. It's a huge industry. It's a fungus. It's absolutely not impossible to get rid of. But you will get marketed treatments, not cures (it'll cure the fungus on your foot, but you'll quickly get reinfected from your shoes, socks, shower, and so on; and they don't ever try to sell you anything to fix the problem once and for all. Doing so would be a poor business decision.) People don't have it in Japan, hence, no huge stinky-foot industry either. From a business point of view this is just lost profits!

    Umm, Bullshit. Where do you tinfoil hat nutters come up with this stuff. Yes, they get athlete's foot in Japan. Need me to google for you? http://www.japancorp.net/Article.Asp?Art_ID=12391 Now, if you want to claim Japan has a lower incidence, I might believe you because I've never bothered to look up the statistics. However if that is in fact the case, that might be due to a more rigorous cleaning of public pools/showers, (places where it is most likely to be transmitted) in Japan than in the states. Not some secret cure that the American pharm companies are hiding from us.

    Anti-bacterial drugs are relatively easy to make because you can often simply target the cell wall. Fungi are eukaryotes, like humans, and don't have a cell wall. One of the problems that comes along with that is that drugs that damage fungus, also tend to damage humans. Lamisil is a drug you often see marketed on TV. Take enough of it and it is absolutely guaranteed to cure your Athlete's foot. The cure is not hidden from you at all. The problem is it may well also kill your liver before all the athlete's foot is gone. Fungi are hard to kill without killing human cells. Ask any researcher who has had to deal with fungus in their tissue culture.