Slashdot Mirror


Genetic Information on Major Diseases Uncovered

gollum123 writes "A major advance in the genetic understanding behind several of the world's most common diseases is being reported by the BBC. A study tested some 17,000 people to find genetic markers for the various diseases. 'They found new genetic variants for depression, Crohn's disease, coronary heart disease, hypertension, rheumatoid arthritis and type 1 and 2 diabetes. The Wellcome Trust Case Control Consortium (WTCCC) involved 50 leading research groups analyzing the DNA from 2,000 patients for each of the seven conditions and 3,000 healthy volunteers. One of the most exciting finds was a previously unknown gene common to type 1 diabetes and Crohn's disease, a type of inflammatory bowel disorder, suggesting that they share similar biological pathways.' There is also disease by disease data at the BBC."

13 of 176 comments (clear)

  1. Good news, but... by ArcherB · · Score: 4, Insightful

    Can we expect (hope for) laws preventing this information being retrieved or considered when calculating insurance premiums or other times when this may lead to discrimination?

    --
    There is no "I disagree" mod for a reason. Flamebait, Troll, and Overrated are not substitutes.
  2. Welcomed News by Normal+Dan · · Score: 3, Insightful

    This is welcomed news for expecting parents. They can now potentially extract DNA from embryos to determine what diseases they are likely to have. With this technology, they could discard the bad ones and keep the good ones, thus producing healthy children. This may even help thrust forward our next step of evolution.

    Imagine a world full of healthy people. The cost of healthcare would reduce greatly, thus allowing us to spend more on education and furthering the advancement of the human race.

    --
    A unique way to learn a language: http://languageloom.com
  3. Who will have access to this information? by TripMaster+Monkey · · Score: 3, Insightful
    Sorry to have to inject the obligatory dystopian note into what should be a positive story, but that's just how my mind works.

    Who will have access to this information?
    • Law enforcement?
    • The Government?
    • Insurance companies?
    • Prospective employers?
    • (Etc....you get the point...)


    Some people fear that this information will be used to discriminate against disease-prone individuals in vivo...but it's far more likely that the first discrimination will happen long after birth.
    --
    ____

    ~ |rip/\/\aster /\/\onkey

  4. Now everyone has a pre-existing condition by dpbsmith · · Score: 4, Insightful

    Welcome to the brave new world, where everyone has a pre-existing condition.

    The good news is, you'll have knowledge that could extend your life or even save it, if you could get treatment.

    The bad news is, in countries with profit-based free-market medical insurance, you won't be to afford that get that treatment, because insurance companies will jack up their premiums when they find out about you.

    Everyone has seen this coming for decades. Now it's here. I don't think the United States is ready for it.

    1. Re:Now everyone has a pre-existing condition by MightyYar · · Score: 2, Insightful

      If you were waiting for another reason to get rich, here it is!

      What do you mean we aren't ready for it? Today we have no cure for diabetes. If they invent the cure tomorrow, and insurance companies won't pay for it... no one is any worse off. Everyone complains about health care costs rising. Well, you know what? In the 50's when health care was apparently affordable, my Grandfather would have died of the stroke that he had before they gave him the blood thinner that saved his life and the stent in his carotid artery that extended it. Then the Type II diabetes would have taken his feet before killing him if not for the pills that control his blood sugar. Then the heart attack would have killed him without the emergency quadruple bypass surgery. And finally, he'd be dead from cancer except that he had radiation treatment.

      Don't get me wrong, I want everyone to have access to at least some basic level of health care, but one has to realize that each of these advances is going to cost money. Why is it that people expect premium health care when they can't afford premium food, cars, clothes, or a big-screen TV?

      --
      W..w..W - Willy Waterloo washes Warren Wiggins who is washing Waldo Woo.
  5. Re:Humanity be careful what you do with this.. by N3WBI3 · · Score: 2, Insightful

    Abortion was probably a bad example for me to pick because it will, inevitably, cause contention over that and not the larger issue. A poster later put up insurance claims and other forms of discrimination there is no measure to the evil man can do with information evil takes little R&D and comes naturally to us. The benefits you talk about take extensive time to develop and implement.

    --
  6. Definition of discrimination? by Harmonious+Botch · · Score: 2, Insightful

    If I have speeding tickets, and my auto insurance carrier finds out about it, is that discrimination?

    Is it to our long-term interests to force insurers to operate in ignorance?

    1. Re:Definition of discrimination? by FiniteElementalist · · Score: 2, Insightful

      I think there was a law in the works to outlaw discrimination based on genetic information. I remember seeing something about it on ./

      However, the problem with the speeding ticket example is that you made the choice to speed and were then caught on it. People don't get to choose their genes (at least not yet!), and this information is more or less set before birth.

      This may also be another argument that free-market health insurance is flawed, since the profit motive to charge more for the genetically at risk people creates a disincentive for the public health motive of diagnosing and treating/preventing these conditions early.

    2. Re:Definition of discrimination? by JesseMcDonald · · Score: 3, Insightful

      Is it to our long-term interests to force insurers to operate in ignorance?

      isnt that the point of insurance? if insurance companies knew with 100% accuracy how much they're going to have to shell out for you, then they're going to charge at least that much, and then there's no point in getting insurance.

      The purpose of insurance is to mitigate unknown, future risk. Anything that can be used to reduce the present uncertainty in the risk is a perfectly reasonably factor in determining premiums. Insurance is a way of trading future risk for present cost within a given risk-class equivilency group. It works best when the risk classes are finely divided; in other words, when the premiums paid reflect the best known estimate of the individual insuree's risk.

      If you were to force the insurance agency to charge a single premium, ignoring individual risk factors, then those who know they have less risk will find the premiums excessive and choose not to participate. As a result the premiums would have to be increased, and yet more marginal customers would leave. In the end you'd be left with just the highest-risk customer(s) paying a premium appropriate to their level of risk. All "non-discriminatory" insurance really does is make it impossible to get low-risk insurance.

      As for the specific problem of being born with an expensive genetic issue, I think there is a way to leverage insurance here as well: the parents can take out an insurance policy on the child prior to conception, based on their own genetic risk factors.

      --
      "The state is that great fiction by which everyone tries to live at the expense of everyone else." - Bastiat
    3. Re:Definition of discrimination? by brunascle · · Score: 4, Insightful

      If you were to force the insurance agency to charge a single premium, ignoring individual risk factors, then those who know they have less risk will find the premiums excessive and choose not to participate.
      that's assuming that someone who believes they will pay more for insurance than will get out of it wont sign up, which is clearly not the case. the average person pays more than they get from it, otherwise the insurance companies would go out of business.

      the average person is paying about average healthcare. you're probably paying close to average. if you believed you were low risk, would you opt-out? i wouldnt.
  7. Re:Humanity be careful what you do with this.. by Anonymous Coward · · Score: 4, Insightful

    I'm sure that most level-headed people would agree that actually terminating a pregnancy due to very small unfavorable genetic traits such as those you mentioned is completely wrong.

    So....why? Doesn't the freedom to choose whether or not to end a pregnancy include the freedom to choose to end it for any reason or no reason at all? If it's wrong to terminate for these reasons, what makes it okay to terminate for other reasons, or no reason at all?

    Posting anonymously because I just want you to think about this. I don't want to deal with a flood of flames.

  8. So what is the downside? by VE3OGG · · Score: 3, Insightful

    Now this is something I have thought about long and hard (though no hard research to back it up) about. WHat happens when we do get the power to *poof* the bad genes out of existance from an unborn infant? Well, obviously they won't develop "problem A", but what about other factors? For instance, I know that black people in regions of Africa are born with sickle-cell anemia, but this also helps prevent a certain disease commonly transported by insects in the region. How do we know what (if any) other things might depend on that particular gene?

    And on that note, someone mentioned that this may well lead us to our next step in evolution -- that may well be true, but shouldn't evolution happen in response to natural factors by nature's invisible hand? Not some doc in a lab? I mean, so many people on Slashdot are keen on letting the "ivisible hand of capitalism" work the market, why shouldn't we let nature decide what is best for us?

    I believe this sort of thing was covered with the Asgaard in Stargate SG-1, they died out because they genetically modified their bodies past a certain point where they could no longer reproduce, only extend their own lives. Now, I am not saying there is any scientific basis for something liek that happening, but aren't parables supposed to make you at least think before acting?

  9. Interesting reading the comments here by MikShapi · · Score: 2, Insightful

    I'm reading all the morals police comments here, and I'm quite surprised.

    Will someone PLEASE explain to me how the ability to diagnose diseases better and earlier is a BAD thing?

    There are numerous eggs and numerous sperm to make numerous children by any couple.
    When one of each gets a chance at life, a lot of others don't. One lives, others die. If we leverage genetics and choose zygote X where naturally Y would have gotten, it's a zero-sum morals game. A different one lives. As they're not yet anywhere near development, putting morals on this is akin to calling masturbation genocide. LOTS of potential human beings never get to live. It's the natural order of things. Forcing morals onto this and blaming people for it is nothing short of lunacy.

    The other side of the coin is, of course, that a LOT of life-ruining conditions (not only for the affected individual, but quite often for his entire family) are simply side-stepped.

    Discarding 41st-week pregnancies due to a disliked color of hair is easily avoidable using legal regulation where otherwise sane laws don't exist (say, laws allowing the mother the first part of her pregnancy to decide whether she is ready to commit and allowing her to abort, yet disallowing non-medically-motivated abortion once a certain reasonable point in the pregnancy is crossed, much like you can't just kill your 3-year-old because you don't want to commit to growing him).

    Yet how do these mild, pathetic and trivial-to-overcome "dangers" reason to bash the enabling technology that would save so much grief?

    --
    -