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MIT Finds Cure For Fear

Doom con runs away writes "MIT biochemists have identified a molecular mechanism behind fear, and successfully cured it in mice, according to an article in the journal Nature Neuroscience. They did this by inhibiting a kinase, an enzyme that change proteins, called Cdk5, which facilitates the extinction of fear learned in a particular context."

3 of 523 comments (clear)

  1. Cdk5 Inhibition != Fearless by Stefanwulf · · Score: 5, Informative

    As I read this article, it isn't about making something fearless or preventing fear...it's more about increasing the rate at which a learned fear response decays in the absence of reinforcement. Essentially, the brain has built in mechanisms to "cure" fear on its own, given enough time without reinforcement of that particular fear. Inhibition of this enzyme--oddly enough one linked with plasticity and neural development--makes that process easier/faster.

    If I understand correctly, then they are right in saying this would be potentially wonderful for treating cases of PTSD where the fear response does not significantly decrease even at points in time far removed from the initial trauma, but I don't think we have to worry about inhibition of this enzyme erasing people's ability to feel fear or leading to fear-based weapons systems. Those things are almost certainly possible (lesions on the amygdala are thought to tame animals by destroying their ability to feel fear), but I don't think they'll appear as a result of this study.

  2. Bzzt! Wrong. by spun · · Score: 5, Informative

    The first post is more correct, as the drug might actually apply in a situation involving girls. The drug treats learned fear, not the innate fear of combat. It will be used to help control post traumatic stress disorder. Arguably, fear of women is a learned fear similar to PTSD.

    --
    - None can love freedom heartily, but good men; the rest love not freedom, but license. -- John Milton
    1. Re:Bzzt! Wrong. by Gulthek · · Score: 5, Informative

      Well, we get into a complex area, here -- one that this drug will no doubt make much clearer as it becomes clinically available.

      I agree that some children fear heights. Neither of mine did, however.


      That depends on the age of the children. Infants (6-18 months) will gleefully crawl off of heights not because they aren't afraid, but because their underdeveloped eyes and visual reasoning can't see the depth of the fall. After that, if you have a kid who dives off of heights you should feel proud, scared, and may want to consider gymnastics classes so they'll at least know how to fall correctly. :-)