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MIT Finds Cure For Fear

Doom con runs away writes "MIT biochemists have identified a molecular mechanism behind fear, and successfully cured it in mice, according to an article in the journal Nature Neuroscience. They did this by inhibiting a kinase, an enzyme that change proteins, called Cdk5, which facilitates the extinction of fear learned in a particular context."

20 of 523 comments (clear)

  1. It must be in clinical testing... by Anonymous Coward · · Score: 5, Funny

    Because I saw some MIT guys talking to GIRLS!

    1. Re:It must be in clinical testing... by MadMidnightBomber · · Score: 5, Funny

      Please don't use terms without explaining them! For the benefit of other slashdotters: http://en.wikipedia.org/wiki/Girl

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      "It doesn't cost enough, and it makes too much sense."
  2. In unrelated news... by elrous0 · · Score: 5, Funny

    President Bush introduced a bill this week to eliminate all research funding at MIT.

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    SJW: Someone who has run out of real oppression, and has to fake it.
    1. Re:In unrelated news... by gr3kgr33n · · Score: 5, Funny

      they have a cure for that

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      My backup chemistry thesis stored on Data Storing Bacteria mutated; granting me a degree in forensic anthropology. v4sw7
  3. Not news...I found this years ago by sqlguy33 · · Score: 5, Funny

    It is also called Liquid Courage. Drinking enough alcohol leaves me with no fear as well...

    1. Re:Not news...I found this years ago by cp.tar · · Score: 5, Funny

      I must not drink.
      Drink is the mind-killer.
      Drink is the little-death that brings total obliteration to my little fear cells.
      I will face my drink.
      I will permit it to pass through me, but not over me.
      And when it has gone past I will turn the inner eye to see its path.
      Where the drink has gone there will be nothing.
      Only a yellow puddle will remain.
      And thirst. Do not forget the thirst.

      --
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  4. uh oh... by leeharris100 · · Score: 5, Insightful

    Why would you want to cure fear? Fear keeps me from giving in to a friend's bet and swallowing a live hamster. But seriously, unless you could target certain fears to help people with crippling phobias, this seems dangerous.

    1. Re:uh oh... by dotpavan · · Score: 5, Interesting

      yes, isnt fear supposed to be an in-built mechanism to prevent us from putting ourselves in dangerous situations (in which others have suffered bad consequences), just like comedy tells us that everything is OK with a false alarm like situation ["So what I'm arguing is, laughter is nature's false alarm. Why is this useful from an evolutionary standpoint? So what you are doing with this rhythmic stocatto sound of laughter is informing your kin who share your genes, don't waste your precious resources rushing to this person's aid, it's a false alarm everything is OK. OK, so it's nature's OK signal."]

  5. This is scary by Anonymous Coward · · Score: 5, Funny

    I am terrified at the implications of this!

  6. In other news... by Anonymous Coward · · Score: 5, Funny

    ...the Darwin Awards suddenly recieves a flood of new entries.

  7. Peril Sensitive Sunglasses... by fahrbot-bot · · Score: 5, Funny
    Joo Janta 200 Super-Chromatic Peril Sensitive Sunglasses have been specially designed to help people develop a relaxed attitude to danger. At the first hint of trouble, they turn totally black and thus prevent you from seeing anything that might alarm you.

    - The Hitchhiker's Guide to the Galaxy.

    --
    It must have been something you assimilated. . . .
  8. RTFA! by kiick · · Score: 5, Insightful

    I see from all the comments that nobody actually read the article.

    The 'cure' doesn't eliminate any and all fear. It doesn't address situational fear at all.
    What it 'cures' is LEARNED fear responses. It's specific application to, for example, soldiers would be
    for PTSD.

    And even if there was a way to get read of all fear reactions, you'd still have a BRAIN and the ability
    to choose not to do things that you reason are too risky.

    Seriously, read the article. It's interesting.

    Sheesh.

  9. Cdk5 Inhibition != Fearless by Stefanwulf · · Score: 5, Informative

    As I read this article, it isn't about making something fearless or preventing fear...it's more about increasing the rate at which a learned fear response decays in the absence of reinforcement. Essentially, the brain has built in mechanisms to "cure" fear on its own, given enough time without reinforcement of that particular fear. Inhibition of this enzyme--oddly enough one linked with plasticity and neural development--makes that process easier/faster.

    If I understand correctly, then they are right in saying this would be potentially wonderful for treating cases of PTSD where the fear response does not significantly decrease even at points in time far removed from the initial trauma, but I don't think we have to worry about inhibition of this enzyme erasing people's ability to feel fear or leading to fear-based weapons systems. Those things are almost certainly possible (lesions on the amygdala are thought to tame animals by destroying their ability to feel fear), but I don't think they'll appear as a result of this study.

  10. Bzzt! Wrong. by spun · · Score: 5, Informative

    The first post is more correct, as the drug might actually apply in a situation involving girls. The drug treats learned fear, not the innate fear of combat. It will be used to help control post traumatic stress disorder. Arguably, fear of women is a learned fear similar to PTSD.

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    - None can love freedom heartily, but good men; the rest love not freedom, but license. -- John Milton
    1. Re:Bzzt! Wrong. by joshv · · Score: 5, Insightful

      Bologna. Children fear heights from a very early age. Depending on temperament, they also fear strangers, from a very early age. These are not learned fears. They are innate.

      I have an innate fear of combat and confrontation. This is an innate response. I've been in one fight in my entire life, and I suffered no physical harm as a result. I have no learned aversion to fighting or confrontation. But put me in a situation where some big dude is threatening to hurt me and you will get an immediate flight or fight response. Put me in a combat arena where people are shooting at me and bombs are going off, damn straight I am going to be scared, not because my higher reasoning capacities have inferred that being in this environment could result in my death - but because millions of years of evolution have evolved a fight or flight response that tends to result in higher survival rates among those who don't ignore it.

    2. Re:Bzzt! Wrong. by Hijacked+Public · · Score: 5, Interesting

      Similarly, one has to be taught to fear certain aspects of combat I'm not sure about that. When I was in Somalia (Marines) there were people who, on patrols, became nearly paralyzed with fear at the sound of distant gunfire without ever having seen the result themselves. And then there were people who, while we were taking direct fire and after having seen those beside them take hits, never raised their voice when they spoke to me.

      Some dangerous things are kind of nebulous. Electricty, heat, germs. It took mankind a good long while to trace illness to invisible bugs, so it doesn't suprise me that the concept of them being dangerous would be difficult to develop in the mind of a child.

      But associating loud noises with a negative result is more tangible. I'd think that while it might not be entirely innate, it is probably learned early enough in life by a wide enough variety of people to be nearly inescapable.
      --
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    3. Re:Bzzt! Wrong. by kalirion · · Score: 5, Funny

      Arguably, fear of women is a learned fear similar to PTSD

      Just similar? Say that next time your crush dumps you in front of the yearbook committee cameras!

    4. Re:Bzzt! Wrong. by NeilTheStupidHead · · Score: 5, Funny

      To be honest, if I ever had to go into combat, I'd be begging for this stuff. If it works like I suspect it would, you'd avoid a lot of cases of shellshock that way. Okay, I'll be behind you, drug free, retaining the fear-instilled good sense to duck.
      --
      Lose: misplace or fail || Loose: not bound together
    5. Re:Bzzt! Wrong. by Gulthek · · Score: 5, Informative

      Well, we get into a complex area, here -- one that this drug will no doubt make much clearer as it becomes clinically available.

      I agree that some children fear heights. Neither of mine did, however.


      That depends on the age of the children. Infants (6-18 months) will gleefully crawl off of heights not because they aren't afraid, but because their underdeveloped eyes and visual reasoning can't see the depth of the fall. After that, if you have a kid who dives off of heights you should feel proud, scared, and may want to consider gymnastics classes so they'll at least know how to fall correctly. :-)

    6. Re:Bzzt! Wrong. by heinousjay · · Score: 5, Funny

      Wanna check if a fear of bombs is innate? Set off some explosives near a newborn and see how they react.

      I don't know, I've never tried it, but my money is on a total freak-out.

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