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Perfect Crystals Grown by Cancelling Out Gravity on Earth
willatnewscientist writes "Researchers in the Netherlands and Japan have found a way to grow perfect crystals in 'zero gravity' here on Earth. By exploiting the way a powerful magnet influences diamagnetic materials they have been able to grow protein crystals without the defects normally introduced as a result of gravity (The same trick has been used to levitate a frog before). Normally, such crystals are grown in space, such as aboard the International Space Station."
Here's the frog they're talking of:
http://en.wikipedia.org/wiki/Image:Frog_diamagnet
And here's a more boring example with graphite, although maybe more clear:
http://en.wikipedia.org/wiki/Image:Diamagnetic_gr
Beware: In C++, your friends can see your privates!
I feel for the frogs. I've had kidney stones. Even perfect ones would hurt like hell.
1. likely won't work for all proteins. It seems this just allows the crystals to grow BIGGER (which is a very good thing) but doesn't actually make the process easier. Protein crystals are a bastard to grow, depending on a lot of things like solvent conditions, temperature, even vibrations and so on. They only used lysosome as a test, which had been done a long time ago, as a protein, it's easy to produce and purify. You can even order it by the grams cheaply from Sigma, it's sort of the biological equivalent of buying sugar and salt from the supermarket. Would be more interesting if they tackled something more difficult, like a big complex or something.
2. Prions won't crytallise (easily...). They are fibrous. I think the closest type of things people have managed was fibrinogen, and they had to chop up that protein into its core region before it can be done (and it was a major finding when it was published). Prions in its "bad" form aggregates fast and is resistant to a lot of tricks to break it down. Furthermore, even prion in its "good" form seem to lack defined structure, so even the good form isn't going to crystallise that well.
But then it wouldn't grow symmetrically--you'd have to rotate it extremely fast, changing direction periodically and quickly, to achieve that sort of effect.