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Sperm Made From Female Bone Marrow, Men Obsolete?
Shaitan Apistos writes "British scientists have discovered a way to turn female bone marrow into sperm, allowing women to reproduce without the need of male companionship. All children born of this method would be female, due the lack Y chromosomes, and there is high chance of birth defects. Eggs also can be created from male bone marrow, but men looking to reproduce would still need to find a surrogate mother to handle the gestation period. I'd like to take a moment to welcome our new amazonian overlords and remind them that men are still very good at mowing lawns and fixing cars."
I think something people seem to be missing from this is that it could be great for couples (of whatever orientation) with men who are infertile. If sperm can be produced artificially from their bone marrow, they could still father children biologically.
The Daily Mail is considered a tabloid rag by many of us who have lived in the UK because they cater to people with a palate for sensationalist headlines and content. The referenced New Scientist article talking about Karim Nayernia's research was published in April of 2007 but The Daily Mail chose to report it many months later. Regardless, since last year there have been few tangible gains in this field. The problem rests in the fact that converted stem cells can achieve the first 2 of 3 stages towards mature sperm development. Even once this is done there is no guarantee the sperm can actually be used in IVF to create a viable/implantable fertilized egg.
The implications of this research are great but rags like The Daily Mail focus on the most provocative uses such as gay/lesbian couples conceiving and auto-reproduction. Before we can approve this research for use in the public we must ascertain whether the manipulations necessary to force conversion of bone marrow stem cells into spermatogonium or the products of these cells potentially introduce undetectable abnormalities within the genetic code. Next, during the process of spermatogenesis chromosomal crossover introduces genetic variability. Without more details in the original article I wonder if one of the failing stages of development involves this important process. Lastly, auto-reproduction is nearly impossible. Every person carries a set of lethal recessive alleles which manifest themselves in incestuous reproductive pairings--hence why most societies have shunned this sort of relationship. This would almost certainly guarantee the fetus would spontaneously abort.
The real application of this research is injecting spermatogonium eggs in women or men who are infertile. This would revolutionize reproductive medicine because it would allow couples to conceive naturally. However, being in the medical field, there are very valid natural reasons why couples may not be able to reproduce (i.e. certain genetic abnormalities) or why fetuses spontaneously abort that we need to decide as a society whether its prudent to interfere. I don't claim to have the answers but I would welcome discussion in this direction so we can make informed choices in the medical breakthroughs we're bound to see in the next few decades.
Incidentally, the New Scientist published a new article today on the matter discussing the implications of this research. Without having a subscription I can't read more but I certainly wouldn't count out fathers just yet. Having a child is only the first part of the equation. Raising an emotionally and psychologically well-adjusted child still necessitates their role--although many single-parents or LGBT couples may argue this point. Anyway, as a community I hope we're a bit more careful of citing sensationalist publications.