Researchers Modify T-Cells, Make Them HIV Resistant

DieNadel writes to share that naturally occurring proteins called "zinc fingers" are being used in a new approach to AIDS treatment. Using modified T-Cells with the zinc fingers, researchers at the Pennsylvania School of Medicine have shown a reduction in viral load in mice. "'By inducing mutations in the CCR5 gene using zinc finger proteins, we've reduced the expression of CCR5 surface proteins on T cells, which is necessary for the AIDS virus to enter these immune system cells,' explains first author Elena Perez, MD, PhD, Assistant Professor of Pediatrics at Penn. 'This approach stops the AIDS virus from entering the T cells because it now has an introduced error into the CCR5 gene.'"

Comments

Worst summary ever...

[JDevers]

Talk about completely misreading even the one paragraph blurb. Zinc fingers are a large group of protein sub-structures which are used to interact with DNA. This group used them to induce a specific mutation which now seems to be HIV resistant How long this will last is really up in the air though, HIV and all other RNA viruses evolve very quickly.

Re:law of unintended consequences...

[Gat0r30y]

FTFA -

Some people are born with a mutation on their CCR5 gene and therefore do not have a working CCR5 receptor on the surface of their T cells. These rare individuals are immune to HIV infection and seemingly are not affected by the non-functional CCR5 protein. The zinc finger approach aims to mimic this natural immunity.

It would appear that these surface proteins are "superfluous", or at least not really necessary.

Re:This is probably good news

[Red Flayer]

But this technology may provide a way to defend against this virus. By changing the "shape" of our T-cells it will prevent the virus from recognizing its target. This would render it ineffective and be effective against the numerous variants

This does not make the T-cell invisible to HIV, it sets a trap.

T Cell (in sexy voice): How about it, Mr. HIV, do you want to come into my place?
HIV: Om nom nom let me put my arms around you baby... wait, where the fuck do I put my left arm? I can't penetrate without both arms around you!
T cell: All your binding proteins are belong to me.
HIV: I'm going to go hit on someone else. Let go of my right arm, you bastard!
T cell: Om nom nom

Well ok, it's a stretch, the T cell doesn't eat the virus at the end.

But the zinc fingers don't disguise the T-cell, they keep the T-cell from expressing one of the antigens on its surface. So instead of the two binding sites needed for the T-cell to be infected, it only shows one.

Re:law of unintended consequences...

[MrMr]

After having worked in the pharmaceutical industry for about 12 years I can only say: You'd be amazed.
T-cells are part of the immune system, and perhaps you remember this recent infamous TGN1412 experiment involving T-Cells

Re:law of unintended consequences...

[DarkOx]

Well, I am no AIDS expert but from what I understand is HIV does not really kill anybody. AIDS the resulting condition of HIV, is Auto Immune Difficency Sydrome. Basically you immune system stops working and all the other little virus out there take over start to take over all your other cells and with nothing to stop them; that kills you.

So if you screw-up someones immune system in the name of HIV proofing and that causes it to not work then they will have AIDS anyway even if you do manage to kill off the HIV infection. So yea if it turns out these things are "important" you might destroy the immune system faster then HIV would have.