Researchers Modify T-Cells, Make Them HIV Resistant

DieNadel writes to share that naturally occurring proteins called "zinc fingers" are being used in a new approach to AIDS treatment. Using modified T-Cells with the zinc fingers, researchers at the Pennsylvania School of Medicine have shown a reduction in viral load in mice. "'By inducing mutations in the CCR5 gene using zinc finger proteins, we've reduced the expression of CCR5 surface proteins on T cells, which is necessary for the AIDS virus to enter these immune system cells,' explains first author Elena Perez, MD, PhD, Assistant Professor of Pediatrics at Penn. 'This approach stops the AIDS virus from entering the T cells because it now has an introduced error into the CCR5 gene.'"

Comments

Re:This is probably good news

[Red Flayer]

But this technology may provide a way to defend against this virus. By changing the "shape" of our T-cells it will prevent the virus from recognizing its target. This would render it ineffective and be effective against the numerous variants

This does not make the T-cell invisible to HIV, it sets a trap.

T Cell (in sexy voice): How about it, Mr. HIV, do you want to come into my place?
HIV: Om nom nom let me put my arms around you baby... wait, where the fuck do I put my left arm? I can't penetrate without both arms around you!
T cell: All your binding proteins are belong to me.
HIV: I'm going to go hit on someone else. Let go of my right arm, you bastard!
T cell: Om nom nom

Well ok, it's a stretch, the T cell doesn't eat the virus at the end.

But the zinc fingers don't disguise the T-cell, they keep the T-cell from expressing one of the antigens on its surface. So instead of the two binding sites needed for the T-cell to be infected, it only shows one.