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Towards an Exercise Pill

aztektum among many other readers sent us news that medical researchers have developed two drugs that can build muscle tone in mice without exercise. While such an advance may inspire dreams of a "couch potato pill," the article mostly talks about other medical uses, should the drugs prove safe and effective in humans. The doctor in charge of the research is working with sports authorities to develop a test to detect the drugs in athletes. "Researchers at the Salk Institute in San Diego reported that they had found two drugs that did wonders for the athletic endurance of couch potato mice. One drug, known as Aicar, increased the mice's endurance on a treadmill by 44 percent after just four weeks of treatment. A second drug, GW1516, supercharged the mice to a 75 percent increase in endurance but had to be combined with exercise to have any effect. 'It's a little bit like a free lunch without the calories,' said Dr. Ronald M. Evans, leader of the Salk group."

6 of 362 comments (clear)

  1. The heart muscle? by Anonymous Coward · · Score: 5, Interesting

    What about the type of muscle tissue found in the heart? Could this be used to help rebuild a heart that's been weakened by a heart attack?

  2. Re:Better Living Through Chemistry by Darkness404 · · Score: 4, Interesting

    Exactly. Just like the steroid "problem" in baseball, if all the athletes take steroids, then how does one team/player have an advantage over another?

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  3. Re:Better Living Through Chemistry by CogDissident · · Score: 4, Interesting

    I don't know. Maybe because the "Rich And Wealthy" would be the only ones who could afford it, and thus we'd have an upper-class composed of bodybuilder supermen, and a lower class consisting of only the frail.

    Kind of like today, but in reverse.

  4. Countertop meat machine by Conspiracy_Of_Doves · · Score: 4, Interesting

    Isn't the biggest problem (ok, biggest technical problem) with in vitro meat the fact that the muscle tissue that it grows can't get any exercise and is therefore soft and textureless?

    Couldn't this help with that problem?

  5. Space Exploration Applications? by halsver · · Score: 5, Interesting

    Presuming that this will be safe for use in humans, could this be one of the missing keys for space exploration? I'm imagining Joe Astronaut wakes from his month-long slumber on route to Planet X. His muscles have atrophied over this time, but by using these pills and doing some remedial exercise, he is ready to face the perils of the alien planet in days!

    I 3 the future.

         

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  6. Re:Better Living Through Chemistry by Rogue+Haggis+Landing · · Score: 4, Interesting

    The problem is that it unbalances the game.

    If everyone was taking steroids, you'd have to greatly extend the outfield so as to keep the game from becoming even more of a home run contest than it currently is. And, since steroids don't make you that much faster (as compared to how much further you can hit a ball), outfielders wouldn't be able to cover all that extra room, and batting averages would skyrocket.

    There are a few problems with this. One is that we really don't know that steroids make everyone a much better baseball player. If you look at the list of players who've been suspended you see a lot of names like Matt Lawton and Mike Morse, and not too many stars. Maybe this just means that the stars can afford untraceable stuff, but we don't really know. But really, and this surprises people, there is very little proof that steroids really help a player become better, and, even if we assume they do, little explanation of how they do it. Is it pure strength? An increase in hand-eye coordination? Some people suggest they improve vision. Can they work with all people equally? If not, why, and who benefits most?

    More importantly, baseball can be changed very significantly with fairly small adjustments to the rules that govern it. An adjustment in the height of the pitcher's mound after the 1968 season increased scoring by about a run a game. Juiced balls dramatically increased run scoring for one season in both 1930 and 1987. The Colorado Rockies have radically changed the offensive environment of their ballpark in large part by changing the method in which they store baseballs (they keep them in a humidor now).

    There are all sorts of things that could be done to "deaden" the game. Mandate a minimum thickness of bat handles -- whip-handled bats allow incredibly quick swings. Deaden the ball if you want. Raise the mound. Enforce a larger strike zone. Force batters to stay in the batter's box, and don't let them wear Craig Biggio-style body armor so they have to worry about getting hit if they lunge over the plate. Call it a strike if they get hit over the plate, or if they make no effort to get out of the way. Limit the amount of times a pitcher can throw to first with a runner on, encouraging base stealing and making speedy, athletic players more valuable than lumbering sluggers. Etc., etc.

    Bill James runs through these ideas and more in his Historical Baseball Abstract. As James says, with only small changes in the equipment and rules, baseball has been a game of 10-9 slugfests and of 3-2 bunt and steal games. It could be either one now, but Major League Baseball thinks that home runs bring profits. So that's what we've got.