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Safe Stem Cells Produced From Adult Cells

hackingbear writes "Wired, citing a paper published in Science magazine, reports that Harvard scientists may have found a safer way of giving a flake of skin the biologically alchemical powers of embryonic stem cells by turning adult cells into versatile, embryonic-like cells without causing permanent damage. The technique involves 'adding cell-reprogramming genes to adenoviruses, a type of virus that infects cells without affecting their DNA.' Four-month trials on mice demonstrated that the resulting stem cells are free from unpredictable cancer-inducing mutations. This is definitely a breakthrough in stem cell research." Additional coverage is available at Yahoo, and Science hosts the research paper, although you'll need a subscription to see more than the abstract.

5 of 207 comments (clear)

  1. Re:Hopefully by CautionaryX · · Score: 5, Insightful

    Conservatives have no problem with stem-cell research. The problem is when the stem cells are harvested from a human embryo - during the process we end a human life. The main question about embryonic stem-cells was 'Is it right to kill a human being to potentially save other lives?' With this new breakthrough, it could be possible to save many lives without killing a potential human life.

  2. Re:not reinventing? by homesalad · · Score: 3, Insightful

    Adult stem cells can only form certain kinds of other cells, and thus aren't super useful unless you can find just the ones you're looking for, and lots of them. Embryonic stem cells can give rise to a much wider range of cells and, if you have a good way of growing them outside the body, you can make tons of them. The reason this new method is safer is because it doesn't involve inserting new genes *into the genome*, where it could disrupt important functions (this has happened in the past, for instance, with the gene therapy treatment for X-SCID, which lead to several cases of leukemia). In the new method the four introduced genes are on an extrachromosomal cassette which doesn't integrate into the genome (and eventually degrades), so there's not as much worry about disrupting, say, a tumor-suppressor gene. Of course, that's not to say it's completely safe....

  3. Re:Doesn't matter by Artraze · · Score: 5, Insightful

    It's not too far unlike the the reason why labor laws generally do not allow you to opt-out (minimum wage, lunch, etc). While it is understandable that workers may want to on their own accord, it becomes extremely difficult to prove that they weren't encouraged to by their employer.

    Similarly, if we're allowed to harvest organ from people we killed on purpose, how can we be sure that the person was killed for legitimate reasons? So we look to legislation to minimize any positive side effects to a person's death.

    And likewise, while embryos might not count as human life, they are human. By allowing people to harvest stem cells from them, you are putting utility in destroying human could-be-life. The end result is not awfully far from _farming_ human could-be-life since, as above, proving things like 'abandoned' is difficult. This doesn't sit well with a lot of people, and especially so with those that view embryos are full fledged human life.

  4. Re:Hopefully by nospam007 · · Score: 4, Insightful

    >...With this new breakthrough, it could be possible to save many lives without killing a potential human life.

    Yep, all those unneeded fertilized embryos now go straight to the incinerator, no stop for any life-saving harvesting in between.

  5. Only for contrarians. by Valdrax · · Score: 3, Insightful

    There's plenty of material and interpretations for anyone who wants to find controversy.

    Only if you're being a sophist. The people who are upset at fetal stem cell research aren't just making up clever arguments to dump all over people's hard work and potential medical salvation -- they genuinely believe in the whole "life starts at conception" argument.

    You may not agree with pro-lifers, but you're not going to convince them to change their minds or find middle ground with the ones that are on the fence about fetal stem cells with ridiculous straw man arguments. And you're never going to make a difference if you have nothing but contempt for the other side's beliefs and the honesty with which they hold them.

    Really, that applies to all of politics, faith, taste, and any other subject with an emotional element that can't be reduced to a simple proof of facts.

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