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Repairing Genetic Mutations With Lasers?

Posted by ScuttleMonkey on from the shed-a-little-light-on-your-genes dept.

Roland Piquepaille writes "German researchers at the Christian-Albrechts-Universität zu Kiel (CAU) think they've proved that genetic information can be controlled by light. The group studied the interaction between the four DNA bases — adenine (A), cytosine (C), guanine (G), and thymine (T) — by using femtosecond time-resolved fluorescence spectroscopy. The researchers think that they've demonstrated that DNA strands differ in their light sensitivity depending on their base sequences. The team thinks that it might be possible in the future to repair gene mutations using laser radiation. One of the project leaders said that 'it might even be possible under some circumstances to make transistors from DNA that would work through the hydrogen bonds.' It's not the first time I've heard about DNA computing, but this new approach looks promising."

1 of 65 comments (clear)

  1. very bad summary by Rutulian · · Score: 3, Informative

    Ok, that certainly has to be the worst layman's summary of a scientific paper I have ever seen. The actual article is here. You will need a subscription to Science to read it, which most university libraries have. The researchers have used time-resolved fluorescence spectroscopy to measure excited state lifetimes of DNA molecules. They found--surprise!--that the mean lifetimes are dependent on the structure of the molecules, which is ultimately dependent on the sequence.

    These are very difficult experiments to do, and the data is good, but there isn't anything particularly breathtaking about the results. Perhaps the resolution is a bit amazing. It is theoretically expected that sequences of 5'-d(AAGAAAAGAAAAGAAAAGAA)-3' and 5'-d(AAGAAGAAGAAGAAGAAGAA)-3' would have different decay properties, but you might not expect it to be measurable by an ensemble technique.

    Anyway, none of this has anything to do with the summary. This isn't "light sensitivity" of DNA. This can't be applied to DNA sequencing, at least not in any practical way. And there is no possibility of repairing genetic mutations with light. The computing thing...also quite a bit of a stretch. Of course, this isn't Roland's fault. He just quoted the German press release....