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Scientists Identify a Potentially Universal Mechanism of Aging

cybergenesis2008 points us to a summary of research out of Harvard Medical School in which a set of genes known to affect aging in yeast was found to affect aging in mice as well. The genes, called sirtuins, perform two particular tasks; regulating which genes are "on" and "off," and also helping to repair damaged DNA. As an organism ages, the frequency of damage to DNA increases, leaving less time for the sirtuins' regulatory tasks. The increasingly unregulated genes then become a significant factor in aging. Realizing this, the researchers "administered extra copies of the sirtuin gene [to the mice], or fed them the sirtuin activator resveratrol, which in turn extended their mean lifespan by 24 to 46 percent." We discussed the plans for this research a few years ago.

6 of 359 comments (clear)

  1. Re:Immortality is scary by owlnation · · Score: 3, Interesting

    This won't be something for humanity to celebrate. If and when the day comes, then we'll have to answer the question of what happens when numbers increase but resources decrease?

    What will happen? I can answer that in one word -- "rebellion"

    The rich may not age, but they will still bleed.

  2. Hmmm by Reality+Master+101 · · Score: 3, Interesting

    There are two problems I see with the usual theory that aging is related to "accumulation of damage", as the article seems to imply:

    1) Humans live, barring accidents and disease, about 80-90 years, 120 at the outside. My dog lives 15-16 years, 22 on the outside. My dog gets all the normal signs of aging -- arthritis, gray hair, join and muscle pain, etc. But at an age that humans are not even entering their physical prime.

    2) From a certain point of view, there is only one organism on earth, and it's billions of years old. Pieces of the organism fall off now and then, but it constantly renews itself. Slightly different each, but going through a consistent cycle of "physical prime". How can it renew itself when, presumably, all cells are "accumulating damage"?

    --
    Sometimes it's best to just let stupid people be stupid.
  3. Re:Immortality is scary by c6gunner · · Score: 3, Interesting

    There are many economists, researchers, and liberal arts majors, along with about 200 million working poor, that very much disagree with you. But you can ignore the liberal arts majors.

    You can ignore all of them. There are also 100 million Americans who believe that the Earth is being visited by little green men who have nothing better to do than shove metal objects in the anal cavities of dirt-poor yokels in Middle-Of-Nowhere, Idaho. Just because an idea is popular, that doesn't mean it's true.

    As for the original claim - he's absolutely right. Most people don't accumulate wealth, they spend it. That's part of the reason why the US is in such a hole right now - because people like living beyond their means.

    What you and the other numbnut are referring to is the infinitesimal percentage of people who actually know how to make large amounts of money, and use it wisely. Personally, I don't give a damn if those people manage to "hoard" ten times what they can accumulate today - they generally generate so much wealth and advancement in the process of acquiring their wealth that their personal fortunes pale in comparison. You and your buddy can bitch about Bill Gates and Richard Branson all you like, but each of them does more good for the human race in one day than you will in a lifetime.

  4. Re:Immortality is scary by Free+the+Cowards · · Score: 4, Interesting

    Medicare is going bankrupt because aggregate costs are increasing. But that says nothing about individual procedures. If we wanted to provide 1950-level care today, it would cost less than it cost in 1950. But we expect better, and so we pay more, even though the cost of the individual pieces has gone down.

    --
    If you mod me Overrated, you are admitting that you have no penis.
  5. Re:Immortality is scary by nugneant · · Score: 3, Interesting

    Because the "anti-arthritis" gene may be a recessive trait. Alternatively, if you kill their entire families, eventually you'll either have to draw a line somewhere, or wipe out the entire planet. No, it'd be much more logical to have a harem of healthy thirty year old women ready to procreate with any 90 year old man not suffering from arthritis. Hopefully it's not an X-linked gene.

    DISCLAIMER: I'm not a scientist, or even particularly intelligent

  6. Re:Immortality is scary by gregorio · · Score: 4, Interesting

    The investment class doesn't "provide jobs and growth" so much as it skims wealth off of the top. The U.S. GDP is about $14 trillion, the workforce of about 150,000,000: the average American worker creates about $93,000 worth of value per year. But the average annual wage is only about $39,000.

    Except that economics doesn't work that way. The GDP is not about "creating value", but mostly about moving money around. You're also wrong when you talk about "the average American worker" when mentioning TOTAL/COUNT.

    General Electric has a Net Income of 22 billion dollars, and 370 000 workers. That's nearly 60 thousand dollars worth of profit for every single employee. So an extremely profitable company will yield something like 2/3 of your estimate. Even worse when you consider that GE is a good employer.

    If you compare GE's 60k USD and your mentioned average 40k USD, it's a pretty fair game: their profits are not based just on their workforce but also based on more than half a trillion dollars in debt and more than 130 billion worth of assets. Taking only 60k of profit per employee while having to finance such a massive infrastructure is pretty fair.

    You also fail to account the fact that most companies are owned by the average american. While powerful banks such as Goldman Sachs and JP Morgan are the first-tier owners of billions of dollars worth of stocks, they're actually buying them in the name of pension funds and also using money borrowed from your bank account.