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Scientists Map Neanderthal Genome

goran72 writes "In a development which could reveal the links between modern humans and their prehistoric cousins, scientists said they have mapped a first draft of the Neanderthal genome. Researchers used DNA fragments extracted from three Croatian fossils to map out more than 60 percent of the entire Neanderthal genome by sequencing three billion bases of DNA."

16 of 229 comments (clear)

  1. FOXP2 by Chrisq · · Score: 4, Interesting

    The interesting thing is that Neanderthals has the same version of FOXP2 as modern humans. This makes it more likely that they had proper speech rather than just "grunting" sounds.

    1. Re:FOXP2 by jw3 · · Score: 5, Informative

      Yes, it is fascinating, but you have to take into account that FOXP2 is a transcription factor that acts when "collaborating" (dimerising) with other transcription factors (or itself) to regulate a whole range of different genes, which in turn can affect a whole range of physical (phenotypical) features (like speech development). True, people who have a mutation in FOXP2 are normal, but are not able to coordinate the movements required to speak, and this is a quite specific effect. But FOXP2 has definitely other "applications" as well - it is required for correct brain development in general, for example.

      This makes any changes (or lack of them) very hard to trace back to specific effects. The fact that neanderthals had the same "version" (allele) of this gene might be an indicator, but then -- it might just be a coincidence. Chimps are just two mutations away.

      What complicates the picture even more is the fact that not only the actual sequence of the protein matters -- also the regulatory sites around it (where other transciption factors bind and promote / inhibit the activation of FOXP2). And these tend to be variable even when they work very similarily.

      j.

    2. Re:FOXP2 by jw3 · · Score: 4, Informative

      Having or not having FOXP2 is not the point. The point is that neanderthals had exactly the same allele, the same sequence of FOXP2 that we humans have. And that small changes to this sequence render humans speechless.

      In other words: having a gene for eye pigmentation does not make you blue-eyed. But having a particular version of this gene can. Some people think that this particular version of FOXP2 is necessary for correct speech development.

      j.

  2. Re:what if by arogier · · Score: 4, Funny

    Hey, maybe the zoo can take care of my student loans if I have enough neanderthal markers in my personal genome.

  3. 60 percent by Shrike82 · · Score: 4, Insightful

    Doesn't the significance depend hugely on what genes were included in the 60% that have been mapped? We're supposed to share 50% of our DNA with fruit, 60% with fruit flies and 98% with chimps, so this incomplete map might tell us absolutely nothing, except that Neanderthal man is closely related to bananas and chimps, and that they were actually overgrown fruit flies.

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    1. Re:60 percent by daniorerio · · Score: 4, Informative

      Actually we share 60% of our genes, not DNA with fruitflies, same for chimps. Which means that for 60% of the genes in our genome you can find a similar gene in fruitflies, although the structure of that particular gene has changed in fruitflies and humans independently over time.

      Since neanderthals are much more related to humans one would expect the number of gene orthologs between humans and neanderthals to be between 98% and 100%. All the genes they mapped will probably genes that humans also have, the interesting bits may come from differences in those genes between the two species. And of course the genes that humans have and naederthals not (or vice versa) but my guess is they haven't mapped those yet. It's easier to map a gene if you know what you're looking for (human ortholog).

  4. Re:what if by BadAnalogyGuy · · Score: 5, Funny

    You should not be in the zoo. No, you should not be in the zoo. With all the things that you can do, the circus is the place for you.

  5. Re:Wonder where the stories about trolls come from by MichaelSmith · · Score: 4, Funny

    Wonder where the stories about trolls come from?

    Here?

  6. Re:Ethics and cloning by Chrisq · · Score: 4, Informative

    Just because they may look structurally similar to humans, they aren't human.

    I really, really hope this is a troll; the same has been said of Jews, Black people, Irish, Native Americans and many more.

  7. That is not what you think :-) by jw3 · · Score: 5, Informative
    Please, don't. Don't make the jokes on cloning / restoring the Neanderthal. We all know it'd turn out that some of them actually are among us, possibly taking up even prominent positions in our society. Who'd be surprised if the cloned guy looked exactly like the governor of one of US states?

    On a serious note, there are a few scientific issues at stake here.

    First let me explain this "positive selection" stuff from the article. When a mutation within a coding region of a gene takes place, it can either be a silent mutation (no change in the resulting proteins) due to the redundancy of the genetic code, or it can change the amino acid sequence of the protein and thereby possibly its function.

    Now, mutations happen at random. But depending on what kind of an effect the changes have, they might be wiped out by natural selection. For example, mutations in the "core system", the "kernel" of any living cell -- replication machinery usually are wiped out, because the machinery is so finely tuned that most mutations seriously screw it up. If the changes are largely neutral, the ratio of the mutations that have an effect divided by mutations that are silent (so called dN/dS ratio) is roughly equal to what we would expect based on random model, and we speak of neutral evolution.

    On the other hand, environmental pressure, change of times, parasite pressure or many other things can lead to an accelerated rate of evolution -- measured by the fraction nonsynonymous mutations / silent mutations. Thus, one can detect whether a species, gene or genome was subjected to a specific pressure. And if we look at the whole genome, we can tell a lot about what this pressure was. And of course, it works both ways -- we can tell a lot about what the pressure was that shaped us, humans.

    * of course, learn more about neanderthals -- who were they, did they mix with humans (current analyses say no, but who knows what one can find in the whole genome). Were they human at all? Did they really talk? What kind of culture did they have?

    * by learning about divergence between neanderthals and homo sapiens, answer the fundamental questions of biology -- who are we? what makes us different from animals? What made us spread and neanderthals disappear?

    * analysis of genome instead of single genes takes the whole thing up one level.

    * tracing back evolution (in general, it is not only about human evolution) -- not by comparing sequences of organisms that live nowadays, but really going back in time. Among others, this will let us test the tools that we routinely use for phylogenetic analysis (that is, tracing back the evolution).

    Regards,

    j. (who currently works on genome evolution in bacteria)

  8. I kinda doubt it by Moraelin · · Score: 5, Interesting

    I kinda doubt it. Neanderthals went extinct so long ago, that I doubt that any stories or myths from that age would have survived as long.

    We're talking long before humanity invented writing, so the only way it could have survived is if the shaman of a tribe taught his apprentice about it, and so on. For some tens of thousands of years straight. I'd think that's rather unlikely. They had more pressing concerns in the here and now than "those guys our ancestors lived in the same cave with."

    Basically, how many folk stories do we have about woolly mammoths? Why would Neanderthals be remembered more?

    --
    A polar bear is a cartesian bear after a coordinate transform.
    1. Re:I kinda doubt it by oodaloop · · Score: 4, Interesting

      In Australia, the aborigines still have myths about creatures which actually lived there...40,000 years ago. Yes, myths can live on that long.

      --
      Tic-Tac-Toe, Global Thermonuclear War, and relationships all have the same winning move.
  9. Serious question? by BadAnalogyGuy · · Score: 5, Interesting

    The serious answer is that they believe that the bone fragments are either human in origin or mocked up from bones of existing apes.

    There is no Neanderthal species for ID proponents. The answer is either they are human or they never really existed and the evolutionists are involved in a vast conspiracy to validate their own beliefs by creating these "pre-human" humanoids.

  10. It's not about appearances by Moraelin · · Score: 4, Informative

    It's not just about appearances. The Neanderthals:

    - used tools to make other tools. Apes do make improvised tools like sharpening sticks, but only Neanderthals and Homo Sapiens would build a stone axe to use to build a stone spear, and then keep both.

    - skinned animals and tanned the skins

    - built elaborate shelters out of wood and skins

    - used clothes (e.g., made from those skins)

    - built (crude) musical instruments. And not just as in "something that makes noise", but as in, for example, a flute which can play more than one note. So they probably had music too.

    - had a bit of work specialization, which would also mean a bit more complex a social structure, and possibly even some kind of commerce (at least as in, "I'll make you a strong spear if you give me a leg of antelope.")

    - decorated themselves with primitive jewellery and paints (basically early cosmetics)

    - had ritual burial, which would indicate some concept of afterlife or at least remorse. (You don't bother burying someone in the same position, and with his weapon, and stuff, unless you expect it to matter somehow.)

    Etc.

    And according to this research, they probably were as capable of speech as the humans, because they have the same gene.

    Oh, and another bit of trivia: they actually had a higher average brain size than Homo Sapiens. And in a smaller body, too. So if we go by the popular brain-mass/body-mass metric, they should actually be a little smarter on the average.

    So we're not talking just as in "looks like a human", but something that was definitely just as sentient and self-aware as a human. It could probably not just understand that you're experimenting on it, but understand the experiment if you bother explaining the science behind it.

    And if you think that it still makes it ok, because it's still a different species... well, then I'd say your empathy is too broken to be the same as 99% of the humans. You're different. When can we start experimenting on _you_ then?

    --
    A polar bear is a cartesian bear after a coordinate transform.
  11. Re:Ethics and cloning by meringuoid · · Score: 4, Insightful
    The problem would be that, like monkeys, Neanderthals are primates and would probably be the focus of animal rights groups seeking ways to stall the progress of science. Should appearance endow rights? Just because they may look structurally similar to humans, they aren't human.

    This is why it probably won't be done. Cloning a Neanderthal opens up an enormous can of worms. We're able to declare that it's wrong to do certain things to humans, but fine to do the same to animals, because there's a substantial gap between H. Sapiens and the nearest relatives, the chimpanzees. Even so there is serious disquiet over treating the great apes in such a manner, and even experimentation on more distant relatives attracts protest, especially if the animals in question happen to be cute.

    That gap between us and the chimpanzee - and hence the rest of the animal kingdom - exists only because all the intermediates are dead and buried. We draw a line in a conveniently empty space. Now we propose to clone a Neanderthal, and ask on which side of the line he falls. If you say he is a man, then what if we now clone H. erectus? H. heidelbergensis? A. Afarensis? Suddenly we don't have a clear-cut boundary between human and nonhuman, but a continuum of clones. Where is the line drawn, and on what grounds? You might end up defining all the hominids as human, Homo, Pan, Gorilla and Pongo together, and rule out experimentation on them all. Then what of other human rights? Votes for Neanderthals - yes? Votes for Chimps - no? A sliding scale of rights based on intellectual capability? Who administers the test?

    Our whole society is built on the unspoken, unexamined assumption that we know what is human and what is not. Cloning our ancestors in this way undermines that. Which is why I doubt it will be done any time soon.

    --
    Real Daleks don't climb stairs - they level the building.
  12. Re:what if by Raffaello · · Score: 4, Interesting

    Actually during the time neanderthals lived alongside the real human ancestors, they were the smarter species of the two

    Not so. During the time when both Modern Humans and Neanderthals coexisted, Modern Humans, by and large, showed evidence of the more sophisticated material culture (tools, art,etc.). Maybe you're thinking of the fact that, on average, Neanderthals had larger brains? Larger brain size does not = more intelligent. It's quite likely that Neanderthals had larger brains for the same reason that they had short, thick limbs: an evolved adaptation to the extreme cold of glacial eurasia. Neanderthal body proportions were most likely an example of Allen's Rule.