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Sea Sponge Extract Conquers Resistant Bacteria
Science News has an article on research into a compound found in a particular kind of sea sponge that seems to have the ability to restore antibiotics' effectiveness against resistant bacteria. The hope is that, since the compound is not itself deadly or even harmful to bacteria, it may skew the antibiotic-bacteria arms race in our favor. "Chemical analyses of the sponge's chemical defense factory pointed to a compound called algeferin. Biofilms, communities of bacteria notoriously resistant to antibiotics, dissolved when treated with fragments of the algeferin molecule. And new biofilms did not form. So far, the algeferin offshoot has, in the lab, successfully treated bacteria that cause whooping cough, ear infections, septicemia and food poisoning. The compound also works on... [MRSA] infections, which wreak havoc in hospitals. 'We have yet to find one that doesn't work,' says [one of the researchers]."
"Science News has an article on research into a compound found in a particular kind of sea sponge that seems to have the ability to restore antibiotics' effectiveness against resistant bacteria. The hope is that, since the compound is not itself deadly or even harmful to bacteria, it may skew the antibiotic-bacteria arms race in our favor. "
Good thing we're not destroying our environment so discoveries like this can continue to be made.
Shai Schticks:"You don't make peace with friends, you make peace with enemies"
Yeah, they probably thought the bacteria would never come up with an answer to penicillin either.
They've been around an awfully long time, and there's a reason for that: nothing's beaten them yet. Our attempt at suppressing them has been thwarted in just a few decades - not even a blink of an eye on a biological timescale.
I wouldn't be crowing about having the little blighters licked just yet.
Now can we be a bit more careful with it this time? No attempts to coat the planet in a thin layer of the stuff, please. The loss of the best weapons against disease we've ever found is not a fair price to pay for cheaper meat. Hopefully we've learned that lesson, although every time I see a doctor prescribe antibiotics just to get someone out of their surgery, I despair a little.
T+10 years: government bodies approve sea-sponge-enhanced antibiotics for use on humans.
T+12 years: patients start telling their doctor: "My friend told me regular antibiotics don't work. I want sea-sponge antibiotics!
T+17 years: sea-sponge resistent bacteria start to emerge because of patients not completing their courses.
Repton.
They say that only an experienced wizard can do the tengu shuffle.
Ok, besides the mis-spelling of "ageliferin" (for those wondering why Google's not bringing up much)...
This is pretty big, but it's not coming out of nowhere. I'm not too familiar with this particular compound, but it appears to be a bio-film breaker -- most (but not all) of which work by disrupting quorum sensing. What's exciting about this particular example is both its potency and apparent non-toxicity.
If suitable for use in humans, you can expect this to dramatically improvement treatment of various types of infections involving biofilm-forming bacteria -- you find these a lot in Cystic Fibrosis patients, immunocompromised patients, and various infections of catheters and implanted items and such.