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Florida Lab Gets Pregnant

Synthetic Biology, a relatively new field, is seeking to find out what happened to a bunch of chemicals to make them capable of supporting a metabolism, replicating, and evolution. A Florida lab is showing some of the most promising advancements in this direction with their AEGIS (Artificially Expanded Genetic Information System) experiment. "AEGIS is not self-sustaining, at least not yet, and with 12 DNA building blocks -- as opposed to the usual four -- there's little chance it will be confused with natural life. Still, Benner is encouraged by the results. 'It's evolving. It's doing what we designed it to do,' said Benner, a biochemist with the Gainesville, Fla.-based Foundation for Applied Molecular Evolution. In addition to providing an example of how alien life might be cobbled together, synthetic biology has a broad array of uses on the home front."

36 of 149 comments (clear)

  1. AEGIS has been in commercial use for years by Anonymous Coward · · Score: 5, Funny

    KFC rolled theirs out years ago.

  2. many uses by phantomfive · · Score: 2, Funny

    In addition to providing an example of how alien life might be cobbled together, synthetic biology has a broad array of uses on the home front

    Oh yes! Like holding the world hostage!! Now where can I get some mind-controlling synthetic life forms? (don't forget the insulin dependence).

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    Qxe4
  3. I won't believe its alive until ... by Tired+and+Emotional · · Score: 5, Funny

    it engulfs its first white lab coated scientist.

    --
    Squirrel!
    1. Re:I won't believe its alive until ... by MadnessASAP · · Score: 4, Funny

      Do you mean a white scientist with a lab coat, a scientist in a white lab coat, or a white scientist coated in a lab?

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  4. Nerds + genetic-engineering = ...boobs by Anonymous Coward · · Score: 5, Funny

    Who wants to bet me $20 they just use this technology to invent the first self-replicating pet-boob?

    1. Re:Nerds + genetic-engineering = ...boobs by Jeng · · Score: 2, Funny

      Pffft. There are already synthetic boobies.

      Aim lower.

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    2. Re:Nerds + genetic-engineering = ...boobs by gardyloo · · Score: 4, Funny

      Pffft. There are already synthetic boobies.

      Aim lower.

      Synthetic boobies for really old ladies?

  5. Um, guys.... by Itninja · · Score: 3, Insightful

    'It's evolving. It's doing what we designed it to do,'

    Isn't that statement eating itself?

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    1. Re:Um, guys.... by Intron · · Score: 4, Funny

      It's the first intelligently designed evolving system.

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      Intron: the portion of DNA which expresses nothing useful.
    2. Re:Um, guys.... by interkin3tic · · Score: 2, Interesting

      Subject confusion I think. They designed the system to produce evolving artificial bugs, which are the ones doing the evolving. Also they set the system up to evolve (design), but they arent' directing the evolution?

    3. Re:Um, guys.... by marcello_dl · · Score: 4, Interesting

      'It's evolving. It's doing what we designed it to do,'

      Isn't that statement eating itself?

      No, it is proof that the ID vs. evolution argument is bogus.
      Something can both evolve AND be the product of the will of somebody. Also, for a hypothetical eternal god POV, not bound by time, there is no "let's setup something and see how it evolves". It is more like "Let's do it, done.", even if it involves uncertainty, free will, evolution: all of those concepts are bound to time, a god is not.

      A more classic proof of the argument being bogus is the fact that evolution is not a dogma and ID is not an acceptable scientific theory (unless you have scientific proof of a god to back it up, which slashdot has not reported AFAIK :) )

      A cynic proof of the argument being bogus is: it doesn't solve anything, it needlessly divides people, it is perfect for the media to fill up pages instead of giving people useful information.
      No ruling class ever liked their sheep to get too smart.

      Of course, having proved ID independent from evolution and doesn't mean either is true.

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    4. Re:Um, guys.... by atraintocry · · Score: 2, Informative

      I mean no offense here, but I think you're confused about what ID is, and what its purpose is. It's much easier of you just assume ID = Creationism and the attempt to get said Creationism into public schools. See here: See here: http://en.wikipedia.org/wiki/Kitzmiller_v._Dover_Area_School_District#Decision

      ID is not merely the belief in a god that could have designed the universe (plenty of theists acknowledge evolution. The entire Catholic church, for instance). ID is dependent on the creation stories in Genesis, and is strictly anti-evolution. It is a method of promoting the teachings of particular religion, which is something the Supreme Court has repeatedly recognized.

      The term Intelligent Design is, well, "designed" to cause a person to think, at first glance, "oh, they just believe in a creator. That's not so strange". Whereas in reality there is no question that this has to do with Biblical Creationism, at the expense of properly teaching mainstream science in schools.

      What I mean to say is, it's not logic, it's just rhetoric. Don't read too much into it. By attempting to refute it on logical grounds, you do it the service of acknowledging that it's worth your time. Those people are liars and they know it, and the courts know it too. At this point we can just sit back and laugh as they flounder.

  6. Sounds like Intelligent Design by Anonymous Coward · · Score: 3, Interesting

    For the sake of argument, if scientists start "guiding" synthetic life through "evolution" in the lab, isn't that ID?

    If so, does it boost the ID argument for *our* creation?

    Hmmm......

    1. Re:Sounds like Intelligent Design by The+End+Of+Days · · Score: 2, Insightful

      Only if you're trying to make the argument that humans guided the evolution of humans. It's about as logical an argument as I've ever heard from the ID crowd, but it's still pretty stupid.

    2. Re:Sounds like Intelligent Design by MightyMartian · · Score: 2, Insightful

      No more than breeding cows or strains of wheat is an argument for ID.

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    3. Re:Sounds like Intelligent Design by Orion+Blastar · · Score: 2, Interesting

      Or aliens, we could have been some alien high school science fair project that went wrong, so they shot the "Grey goo" to Earth and it evolved into the lifeforms we now have.

      Would it be interesting to find out that we created ourselves via AEGIS and shot it back in time via a time travel paradox?

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    4. Re:Sounds like Intelligent Design by MightyMartian · · Score: 2, Insightful

      Evolution is simply put " change in the frequency of the genetic makeup of a population over time". How is this not evolution?

      Methinks you've spent so much time trying to justify your Creationist tendencies by calling scientists "elitists" that you actually have no idea what they're talking about.

      --
      The world's burning. Moped Jesus spotted on I50. Details at 11.
  7. OT: online news by MichaelSmith · · Score: 2, Interesting
    TFA has this caption:

    Researchers in a Florida laboratory are working with the most asic building blocks of life to try and understand how biology first arose on Earth â" and how it might appear on other planets.

    Seriously, I know these pages are assembled by software from other sources but don't they have spell checking built into them? Lots of otherwise good news sources I read have stupid typos in their online versions. Right now firefox is underlining "asic" for me, pointing out the mistake. It seems like every second article has something like this. It just seems so easy to fix. I wonder why that isn't done.

    1. Re:OT: online news by QuasiEvil · · Score: 4, Funny

      Clearly if I made artificial life, I'd put it on an ASIC. Otherwise you'd just have too many discrete components and general purpose things to get it in a tiny package.

      Then again I'm an EE, and I equate everything biological to the word "slimy" in my mind. Mechanical life for the win...

    2. Re:OT: online news by Tacvek · · Score: 2, Interesting

      Artificial life on an ASIC? How quaint a notion. Artificial life would work better in an FPGA so as to be able to reconfigure large portions of itself. (Although I will of course grant that a custom FPGA may be used, perhaps with some special hard coded logic, which may make it an ASIC if the result is not sufficently general purpose.)

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    3. Re:OT: online news by Merls+the+Sneaky · · Score: 2, Informative

      Yeah she was wearing a little pink number and she was HOT!

  8. Re:Not my fault by DigiShaman · · Score: 3, Insightful

    If she's between 25 and 30, she lied to you. Beware if the biological clock my friend, beware!

    --
    Life is not for the lazy.
  9. Re:grey goo by interkin3tic · · Score: 2, Informative

    Green goo actually, or maybe grayish-green goo would be more appropriate.

    On a more realistic note, those 12 artificial nucleotides they seem to have put in there probably aren't found in the environment make it unlikely anything to come out of it will get very far.

    I do of course realize that "probably" is an issue for some people who seem convinced that any possibility, no matter how small, when it comes to biological nightmare scenarios is an absolute certainty (specifically biology ones, they're more rational when it comes to the chances of the hadron collider destroying the earth). Suprised no one has tagged "iamlegend" or "whatcouldpossiblygowrong" yet.

  10. Re:World domination by interkin3tic · · Score: 5, Interesting

    Anything to come out of those vats would probably need most of the 12 artifical nucleotides, which aren't found in any apreciable quantity outside of the vat. If any gets out it would quickly starve. Not to mention that depending on the conditions that they are evolving under, there might be more immediate problems for anything escaping. Early life evolved under anerobic conditions, oxygen is pretty toxic to cells. They're probably generating these things under anerobic conditions to mimic what were thought to be early conditions of the earth and to maybe encourage things to start growing. I would expect that any bugs growing in this system would be poisoned by oxygen once outside pretty rapidly, much as bacteria from early earth would. Also temperatures are probably much higher in the vats.

    Since the vats are -probably- extremely rich in all 12 artificial nucleotides, devoid of oxygen, and very warm in all places, there wouldn't be any advantage or reason for the bugs to evolve ways of overcoming those conditions. There'd be no reason for them to develop ways of making their own artificial nucleotides since they're provided. In fact that would probably be a detriment, since any way of converting one of the natural 4 would be costly to the cell in terms of energetics and would have no gain, they'd quickly be out-proliferated by their bretheren who don't waste energy on things like that. In other words, once stepping out of the vat, they'd be presented with an extremely harsh environment they're totally unprepared for.

    I am of course making some assumptions there. I guess we can't rule it out entirely, but there are millions of unlikely apocalypses you can't completely rule out.

  11. Re:A first by PitaBred · · Score: 3, Funny

    Nope! That's why it's news.

  12. Re:naming... by interkin3tic · · Score: 2

    A virus that infects single cells which have 8 nucleotides I don't is a virus I laugh at.

  13. Re:World domination by MightyMartian · · Score: 5, Interesting

    I think those are not unreasonable assumptions, providing they're maintained in that environment. The more interesting (and much more nasty) experiment would be to let the critters breed for many generations, letting the fittest gain control of their little ecosystem, then slowly introduce elements of the external environment in, making the habitat *less* supportive. Eventually, and I'm sure this would take a long time (several generations of scientists, say), you would produce an organism potentially capable of surviving outside the vat.

    At that point, of course, it would still have to put up with 4 billion years worth of evolution on the outside, with organisms of considerably more complexity in finding and utilizing food sources. A good example are nylon-eating bacteria. In the space of no more than forty years, a population of bacteria learned how to eat a food that hadn't even existed prior to 1935.

    Any organism we make in a vat would, I suspect, not last terribly long on the outside.

    --
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  14. Re:World domination by jamstar7 · · Score: 3, Funny

    Any organism we make in a vat would, I suspect, not last terribly long on the outside.

    Particularly in the Deep South, where barbeque is almost a religion on its own.

    People for Eating Tasty Animals, anyone?

    --
    Understanding the scope of the problem is the first step on the path to true panic.
  15. Re:grey goo by whong09 · · Score: 2, Insightful

    You realize that microbes already in nature have been evolving the moment they've showed up?
    Any sort of creation we make in the lab right now will ultimately be weaker than any successful microbe.

    Green goos already exist, they cause common colds.

  16. Grey goo and hubris by TapeCutter · · Score: 3, Insightful

    Why do ludites (not accusing you) think artifical nanotech would NOT be eaten by the natural nanotech found around and within us? The people who think scientists can build such a machine are the ones who are guilty of hubris, not the scientists.

    --
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    1. Re:Grey goo and hubris by marcosdumay · · Score: 2, Insightful

      Because artificial machines may be able to deal with a much wider set of chemical reactions than we can. Also because they are inteligently designed and, thus, can be way better optimized than we are.

      I'm not very concerned about it destroying the humanity, but I can see how grey goo may disrupt other species.

    2. Re:Grey goo and hubris by TapeCutter · · Score: 2, Insightful

      I didn't say we can't disrupt nature, we have already done that with the closest thing we have to grey-goo, ie: pollution. My point is that nature will disrupt grey-goo no matter how intellegent or efficient it's design. In fact most, if not all, of said designs will be inspired by observing their natural conterparts.

      --
      And did you exchange a walk on part in the war for a lead role in a cage? - Pink Floyd.
  17. Re:Not my fault by Anonymous Coward · · Score: 2, Funny

    Mod parent up, and enjoy this best of craigslist post about paternity -- "Vasectomy: $400. Speechless look on her face: priceless."

  18. Re:World domination by imhennessy · · Score: 2, Insightful

    To quote Dr. Ian Malcom: "Life. Finds. A. Way."

    It was almost like Jeff Goldblum was channeling Shatner, but acting him as more human than he was when not acting.

    ivan

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  19. Send up a flare by imhennessy · · Score: 2, Interesting

    when they trounce cell theory. A bunch of chemicals which preferentially catalyze feedstock to produce identical/similar chemicals is interesting, and very difficult to do from scratch, but I want CELLS! Self enclosed systems.

    I suppose cells are not really needed for life, but it seems pretty clear that they provide certain advantages, especially in terms of not just getting washed away.

    On the topic of ID: just because there is a chemical reaction that seems to be approaching the fuzzy definition of life we've developed so far, and that reaction is intelligently designed, does not really have anything to do with the real problems that exist with pushing Intelligent Design as an alternate theory to evolution for explaining life.

    This comes up a lot when people want to talk about both religion and science. They exist in different domains. Religion does not propose testable, predictive hypotheses. Science does not purport to provide meaning for existence.

    Intelligent Design is not scientific.
    Genetic evolution is not religious.

    People can chose to reconcile religion and science, or pit them against each other. It is only when one or both are misused that there is conflict.

    That said, the misuse and conflict almost always comes from the religious side. That is based on personal experience and I have no numbers to back it up.

    ivan

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  20. Re:A first by witherstaff · · Score: 3, Funny
    Yeah, I can see the nobel committee giving a prize for really shoddy documentation like so :

    Diary of creating new life :
    • Turned on the light of the lab
    • Opened up the experiment to the rest of the expansive lab
    • Added a little water
    • Played with the lights to have cyclic on off cycles
    • We let the lab bring forth living creatures
    • Took a much needed day off