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Stem Cell Treatment To Cure the Most Common Cause of Blindness

The Times Online reports that researchers from the Institute of Ophthalmology at University College London and Moorfields eye hospital have developed stem cell therapy that can treat age-related macular degeneration (AMD), the most common cause of blindness. They are currently moving the treatment through the regulatory approval process, and clinical trials are expected to start within two years. Quoting: "Under the new treatment, embryonic stem cells are transformed into replicas of the missing cells. They are then placed on an artificial membrane which is inserted in the back of the retina. ... [Professor Pete Coffey, director of the London Project to Cure Blindness] said the treatment would take 'less than an hour, so it really could be considered as an outpatient procedure. We are trying to get it out as a common therapy.'

13 of 126 comments (clear)

  1. This is good and all by Anonymous Coward · · Score: 5, Funny

    But don't let this discourage any mad scientist from creating ocular implants, especially ones with wifi and defensive laser beams.

  2. Straight to stem-cell cures? by CRCulver · · Score: 4, Interesting

    I feel sorry for Larry Niven. Back in the 1960s and 1970s he was writing works of science fiction (e.g. the Gilm 'The Arm' Hamilton stories in Flatlander ) that suggested that organ transplants were going to be so widespread as a cure that even the most minor crimes would get the death penalty. Instead, it looks like the human race may realize stem cell cures faster than anyone could have imagined. Oh, and Kurzweil suggests we'll all be in robot bodies before the century's end, so those great hard science fiction writers of half a century ago fall even further behind.

  3. Still a long way to go... by Anonymous Coward · · Score: 5, Informative

    IAAO (I am an Ophthalmologist).

    Although the article does not mention what kind of cells and membranes are transplanted and wether it is going to be used in exsudative or non-exsudative AMD I would assume that it's retinal Pigment Epithelium and Bruch's Membrane being used in wet (= exsudative) AMD.
    Therefore this seems to involve subretinal surgery, which is not a piece of cake and usually diminishes visual accuity.
    Previous attempts in this direction have already been done (macular rotation, retinal pigment epithelium transplants, etc.), results have not been all too gratifying.

    1. Re:Still a long way to go... by bargainsale · · Score: 4, Informative

      IAAO too ...

      This is, I think, stem cell implantation subretinally for Geographic Atrophy, a.k.a "dry" macular degeneration. Potentially a big deal inasmuch as currently we have no treatment for this at all and it accounts for 90% of all macular degeneration.

      It involves major invasive surgery: "outpatient procedure" gives a highly misleading idea of what's involved. It doesn't mean any more than that you could get away with not admitting the patient to hospital, not that you could ever do it anywhere except in an operating theatre.

      Moorfields have lately developed a very bad habit of prematurely and misleadingly announcing "breakthroughs" in eye treatment, which I suspect is related to their own funding issues (they did this not long ago with some extremely misleading publicity about three patients with Leber's Amaurorosis they'd treated with gene therapy, not one of whom in fact showed measurable objective improvement in vision - not the impression the news reports tried to give.)

      Peng Khaw BTW is not a retinal expert (though Lyndon da Cruz certainly is; he was also involved in the publicity about the gene therapy, interestingly.)

      I'm sorry to say that I think this is the Moorfields spin machine in action.

      --
      Aberrations have appeared in my destiny prognostication engine!
    2. Re:Still a long way to go... by Dachannien · · Score: 4, Funny

      Why are you abbreviating and then writing out the abbreviation? Doesn't that kind of negate the point of an abbreviation?

      Most people on the Tubes would have saved themselves a lot of time by just writing the commonly-used abbreviation, "WAYAATWOTA? DTKONTPOAA?"

    3. Re:Still a long way to go... by bargainsale · · Score: 4, Informative

      No, that's incorrect.

      "Blindness" is being used in this context in a technical but generally accepted sense to mean vision so poor that you can't see the top letter on the eye chart with either eye. That's a grim state to be in, but most people who are "legally blind" like this are far from having no vision at all.

      In particular, Macular Degeneration hardly ever leads to the total blindness you are referring to.

      That doesn't mean it isn't a horrible crippling condition of course.

      --
      Aberrations have appeared in my destiny prognostication engine!
    4. Re:Still a long way to go... by Anonymous Coward · · Score: 5, Funny

      IANAO IAAO (I am not an Opthomologist, I am an Orthopaedist)

      EIEIO (I am a farmer)

    5. Re:Still a long way to go... by ParadoxDruid · · Score: 4, Informative

      I recently met Pete Coffey, the lead scientist on this effort (he collaborates with scientists in a research group across the hall from mine), and attended his technical talk on this procedure. You are correct, they're transplanting retinal pigment epithelium. However, they've done experiments with both wet AMD and some preliminary work with reviving dry AMD. Very promising work; but yes, very involved surgery with a success rate of 75% even for ideal patients.

      --
      This statement is solely an opinion. Kindly take it as such in all cases.
  4. Wow, thank god for that by physburn · · Score: 5, Interesting
    So pleased at the news, losing my eyes, is my number one fear, no eyes = no computers games, no programming, and no porn. Blindness would be sure hell.

    Reading the article, is hardly ready for use, so far only tested on rats and pigs. There'll be many years of trials before its ready for use on people. Plus Stem cells have be known to turn cancerous, cancer of the retina, would be quickly fatal, there so close to the brain.

    Stem cells have tremendous potential to cure disease and even to reverse the aging process. The next twenty years of research might total change the sad process of aging in human.

    Stem cells feed at Feed Distiller

    1. Re:Wow, thank god for that by Anonymous Coward · · Score: 5, Insightful

      Eh, don't get too hung up on it. I'm legally blind and have no trouble with coding, video games, and especially porn. Could be the porn that got me into this mess in the first place (mom always said I'd go blind), but whatever.

  5. A treatment to get rid of AMD? by name*censored* · · Score: 5, Funny

    "On hearing the announcement that researchers have found a cure for AMD, a spokesman for computing giant Intel said 'It's about bloody time.'".
     
    /ducks

    --
    Commodore64_love: I don't comprehend people who're so frightened of death that they'll bankrupt themselves to stay alive
  6. The Most Common Cause of Blindness by Idiomatick · · Score: 4, Funny

    Someone tag this !porn because I was seriously confused for a minute.

  7. Re:Vampirism by Kiuas · · Score: 5, Insightful

    I just don't see how taking the life of an embryo so that the older or sick can keep on living is anything other than vampirisim (in a loose sense of the word, or course).

    Erm, someone correct me if I'm wrong but hasn't this been discussed time and time again. Embryos for stem cell research are not bred just for the purpose of being "killed". The cells, at least acording to what I've heard/read (again, prove me wrong if you know any better, I'm not a professional) are taken from embryos that were fertilized for the purposes of fertility treatment/artificial impregantion. During those treatments multiple embryos are fertilized and some of them are the discared. The stem cells are extracted from discarded embryos. This means that the embryos would "die" anyway and at least this way they're being used for something beneficial.

    Moreover, I don't understand the problem at all. Embryos aren't humans. They are clusters of cells. They are by no means sentient or intelligent. So what's the whole deal about "vapirism"? People donate blood and organs all the time - this is not so far from it. Bottom line is: The embryo is alive in the sense all cells are alive but it has no "life" to be taken away. If you seriously think that way I suggest you stop eating any food because by eating vegetables you're basically taking the life of another organism so that you can live and according to you, that's "vampirism".

    --
    "It is the business of the future to be dangerous" -Alfred North Whitehead