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Gene Transfer Immunizes Against Monkey HIV Analog

Al writes "Researchers at the University of Pennsylvania have immunized monkeys against the simian immunodeficiency virus, the animal model that is closest to HIV. They did so by shuttling a gene into the monkeys' muscles, making the muscle cells produce antibody-like molecules that work against SIV. With both SIV and HIV, the chameleon-like mutability of the virus's surface changes so quickly that most antibodies made by the immune system are soon rendered ineffective. Philip Johnson and colleagues designed DNA sequences for two antibodies known to be effective against SIV. They used antibody-like molecules, called immunoadhesins, in which the functional part of an antibody is fused with a more stable section of another antibody. The same approach could be used to deliver antibodies that are effective against HIV, but which the body doesn't normally produce."

11 of 104 comments (clear)

  1. that's good news.... by gandhi_2 · · Score: 5, Funny

    ...for all the HIV-analogous-positive monkeys.

    1. Re:that's good news.... by flaming+error · · Score: 4, Funny

      I'm waiting to see what they can do with Monkey HIV Digital.

    2. Re:that's good news.... by BaronHethorSamedi · · Score: 5, Funny

      You'd think that, but tragically, most HMOs refuse to cover monkeys, and gene transfer therapy is quite simply beyond the means of working class simians.

      Monkeys, write your congressman!

    3. Re:that's good news.... by clem · · Score: 5, Funny

      unprotected monkey sex, sharing heroin needles, and participating in HIV related research as test subjects

      I miss college.

      --
      Your courageous and selfless spelling corrections have made me a better person.
  2. Another cure? by tim_darklighter · · Score: 3, Funny

    Does the direct injection of large sums of money also work for simians?

  3. Re:Waste of money by Gerafix · · Score: 5, Funny

    The analog version is obviously superior. I can feel the soft, velvety texture of the analog virus whereas the digital version seems rough and blocky.

  4. I am not a sciency guy break it down for me please by Phizzle · · Score: 4, Funny

    Is it safe again to screw the monkeys or not?!

    --
    I will not be pushed, filed, stamped, indexed, briefed, debriefed or numbered. My life is my own.
  5. Re:Waste of money by still+cynical · · Score: 4, Funny

    Yeah, you're probably one of those people that insist on spending a fortune on glass syringes with exotic wood plungers and gold-plated needles, because they feel healthier.

    --
    Ignorance is the root of all evil.
  6. Re:Whoa there, reporter cowboy. by feepness · · Score: 4, Funny

    Yeah, but at least I can sleep with my monkey without worrying...

  7. Re:End run around non-protective responses by OneMadMuppet · · Score: 3, Funny

    floppy sections of their variable regions that allowed them to reach down to contact hidden epitopes

    Best. Euphemism. Ever.

  8. Re:Don't virii evolve extremely quickly? by mutube · · Score: 4, Funny

    Hell some places spread the lies that condoms are a western evil.

    'Some places' like Vatican City?

    Do it right kids, use a condom!