Medical Papers By Ghostwriters Pushed Hormone Therapy

krou writes "The New York Times reports on newly released court documents that show how pharmaceutical company Wyeth paid a medical communications firm to use ghost writers in drafting and publishing 26 papers between 1998 and 2005 backing the usage of hormone replacement therapy in women. The articles appeared in 18 journals, such as The American Journal of Obstetrics and Gynecology and The International Journal of Cardiology. The papers 'emphasized the benefits and de-emphasized the risks of taking hormones to protect against maladies like aging skin, heart disease and dementia,' and the apparent 'medical consensus benefited Wyeth ... as sales of its hormone drugs, called Premarin and Prempro, soared to nearly $2 billion in 2001.' The apparent consensus crumbled after a federal study in 2002 'found that menopausal women who took certain hormones had an increased risk of invasive breast cancer, heart disease and stroke.'"

Comments

Re:Here come the Lawyers

[e9th]

Some the the journals are published by Elsevier, which cropped up here last May for publishing entire bogus journals!

Last time they pimped for Merck, now Wyeth. If anyone needs to be punished, it's Elsevier.

Re:I am a physician

[MMC Monster]

From one doc to another, stop using atenolol. :-) Atenolol is not a particularly good beta blocker. It's advertised as a QD drug, but really should be given BID. In addition, it is renally cleared.

I can't count the number of times the following happened: Patient's renal clearance decreases transiently for some reason. The atenolol buildy up in the system and causes hypotension and bradycardia, causing a further drop in renal clearance. And the cycle continues until the patient ends up in the ER in complete heart block and renal failure or dead.

Use metoprolol ER (generic equivalent to toprol xl) or carvedilol. Both generic and with proven cardioprotective effects.