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Genetic Mutation Enables Less Sleep

reporter writes to tell us that researchers are claiming to have discovered a genetic mutation that allows people to manage with much less sleep. One of the researchers hopes that this could lead to artificially reducing the amount of sleep required in your average human. "Although the mutation has been identified in only two people, the power of the research stems from the fact that the shortened sleep effect was replicated in mouse and fruit-fly studies. As a result, the research now gives scientists a clearer sense of where to look for genetic traits linked to sleep patterns."

33 of 272 comments (clear)

  1. Next up by ausekilis · · Score: 5, Funny

    Maybe they'll find a genetic predisposition of attraction to LCD screens and avoidance of sunlight.

    1. Re:Next up by linhares · · Score: 5, Informative

      Maybe they'll find a genetic predisposition of attraction to LCD screens and avoidance of sunlight.

      Don't joke dude; the gene is named DEC2; I'm sure they'll find it.

      In any case, this is VERY exploratory stuff. They have found the gene in two women only, but were able to replicate it in some poor little mice and fruit flies. Other than that, the lack of details is what is outstanding about the article.

      Oh, for those tagging this as "registration required", just google the effing URL of the NYTimes article, as users that come from Google get a free ride. You gotta hand it to these newspapers guys; they want to block people while getting google love.

  2. Mutation by avandesande · · Score: 4, Funny

    Mutation activated by Mountain Dew and Cheetos

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  3. I thought it said... by realsilly · · Score: 4, Funny

    .... genetic mutation for less sheep. That could cause problems in alabama...

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    1. Re:I thought it said... by NewbieProgrammerMan · · Score: 4, Funny

      And in New Zealand.

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    2. Re:I thought it said... by R2.0 · · Score: 3, Funny

      "genetic mutation for less sheep"

      That would be fewer sheep. After all, the whole point of sleep is to count them...

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  4. I wonder how long.... by 8127972 · · Score: 3, Funny

    ... Before we get Gustav Graves?

    Someone better tell MI6.

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  5. Employment Adjustments by Imagix · · Score: 4, Insightful

    I can see these things coming up: 1) Companies requiring genetic therapy to retroactively apply this mutation to you. 2) Extending the work day as the workers don't need as much sleep

    1. Re:Employment Adjustments by FooAtWFU · · Score: 3, Insightful

      "Certainly, the eugenistic and racial ideologies that in the past humiliated man and provoked immense suffering are not being proposed again, but a new mentality is creeping in that tends to justify a different consideration of life and personal dignity . . . The tendency, therefore, is to give precedence to the active faculties, to proficiency, to physical perfection and beauty, to the detriment of other dimensions of existence that are not thought to matter. This weakens the respect that is due to every human being, even in the presence of a developmental defect or a genetic illness that could be manifested at some point in his life . . "

      ... or when they don't want to be infused with the "latest and greatest" trendy genetic therapy.

      (Pope Benedict XVI, with regards to human dignity in the face of genetic enhancement technology)

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    2. Re:Employment Adjustments by gad_zuki! · · Score: 3, Insightful

      Not everything is a slippery slope. Not all technology leads to dystopia. In fact, these things are rare in an open society.

      For instance, if you read the article the two women get 6 hours a sleep nightly. Err, I do that, but I prefer 7. I dont need 8-9 as the article suggests. Sure, they probably get better sleep then I do and feel more refreshed, but you inserted that gene into me it wont lead into any big changes.

      This isnt exactly discovering a gene that can let us get by with 2 or 3 hours a night. Its shaving off maybe one. I wouldnt be surprised to find out that this gene really does fuck all for the average person.

    3. Re:Employment Adjustments by gad_zuki! · · Score: 5, Insightful

      >Pope Benedict XVI

      The guy who is against condom use in Africa, runs his own country, believes non-christians deserve eternal torment, and walks around with a solid fucking gold staff while lamenting the world's poor?

      Sorry, we dont need someone with a 13th century worldview telling us what to do. Between secular moralists, secular ethics boards, FDA, AMA, et al, we are doing fine thanks. Men in dresses who think they talk to the invisible men in the sky arent helping. In fact, historically they've only hurt society.

    4. Re:Employment Adjustments by Vexorian · · Score: 3, Insightful

      Holy ad hominem batman! Why did you jump on the defensive so fast? You know that you can agree with what the pope said in that paragraph and not necessarily be against condoms in Africa, right? I think that in this case he was completely right.

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    5. Re:Employment Adjustments by Isbiten · · Score: 3, Interesting

      A Toyota shop near me introduced 30h working week for it staff. They kept the same pay but worked 6h days instead of 8h. Guess what productivity went up, the shop had longer opening hours 12h (2 shift) vs 8h (1 shift). People got sick less, fewer mistakes were done, customers were happier and revenue went up.

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  6. Great by Cornwallis · · Score: 3, Funny

    Now we can look forward to 22 hour workdays. "You got your two hours of sleep you wuss!"

  7. Boy, this sounds great ... by richg74 · · Score: 4, Interesting
    If I can spend a lot less time sleeping, just think of all the cool stuff I can do:
    • Watch all the really worthwhile programs on TV
    • Listen to politicians trade lies about health care
    • Read more blogs, so I can learn more about abnormal psychology

    On second thought, is slitting my wrists an option?

    1. Re:Boy, this sounds great ... by Hurricane78 · · Score: 3, Insightful

      If you want to slit your wrists, would you do me a little favor before you do it?
      Please just take as much politicians, lawyers, marketing managers and phone sanitizers with you as you possibly can. ;)

      --
      Any sufficiently advanced intelligence is indistinguishable from stupidity.
  8. Define "manage" by CannonballHead · · Score: 4, Insightful

    What exactly does "manage" mean? Does that mean you actually are more efficient and your body works just as well with less sleep? Or does it mean your brain functions better when tired... or that you don't actually GET tired? Or does it simply mean you can go longer before you burn out completely. Or whatever.

    "Managing" and being "productive" are quite different... and subjective.

    1. Re:Define "manage" by eln · · Score: 4, Funny

      Speaking from personal experience, it's that yu dnt knead as much sleap...for exmpl, I don't need as much sleep ass othres dew...I meen, Ive been up for almstr 3 dys straight, and i;m stll operatig at peak form,,,my mind is stll sharp, and safdgege ewMONKEYS!!#@! Sorry about that, I thnk I blcked out for a secnd...what was I talking abt...oh right, ppl who say yu need to sleep EVERY DAY r full of sht.

    2. Re:Define "manage" by MyLongNickName · · Score: 5, Funny

      I nominate you for Slashdot Editor.

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  9. Presence of Restoration Effects in These Subjects? by eldavojohn · · Score: 5, Interesting

    Anyone with access to the paper know if they analyzed the naturally short sleepers for lack of benefits from sleeping? An immune system deficiency? Metabolism rate? Increased food intake? Accelerated aging? Memory and learning issues? Biomass, muscle & organ development?

    I'm not a biologist and I don't know what sleep durations are for other mammals but the scientist in me wonders why we settled out at eight hours a day if we are more vulnerable with our eyes closed. You would think it performs pretty important functions (or did perform) for the 5 percent of short sleepers not to collect more food and proliferate more efficiently and more frequently than the other 95% 8 hour sleepers. Perhaps in times of famine or disease this 5% are more susceptible and since we no longer have them they are freed from these shackles? Perhaps (since the two subjects noted were ages 40 and 70) this only becomes apparent with the onset of age that we never made it to back in the day? Any other ideas?

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  10. Age related? by infinite9 · · Score: 4, Interesting

    I wonder what their sleep patters were like when they were teenagers. When I was in high school, I needed at least 10 hours, and preferred 12. Now that I'm almost 40, I can easily operate on 3 or 4 hours, routinely get 6, and sleeping in on saturday is 8 or 9.

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  11. Re:Presence of Restoration Effects in These Subjec by MyLongNickName · · Score: 4, Insightful

    I came here to make a similar remark. A mutation like this would seem to be highly beneficial. Wouldn't you expect to see more of it in the population if it didn't have some downside to it?

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  12. Jolt by NES+HQ · · Score: 3, Funny

    Can we call it the Jolt Cola mutation?

  13. They *feel* they had enough sleep by drunken_boxer777 · · Score: 3, Interesting

    They ... found a mother and daughter who were naturally short sleepers. The women routinely function on about 6 hours of sleep a night; the average person needs 8 to 8.5 hours of sleep.

    âoeWhen they wake up in morning, they feel they have slept enough,â Dr. Fu said.

    These women feel they've had enough sleep, but that doesn't mean that they are fully rested and recovered from their previous day's activities. While I don't have access to the journal article, I would be interested in seeing whether mice or flies with the homologous mutation have shorter life spans or other problems that accrue over longer periods of time.

  14. This Guy Hasn't Slept for 30 Years by juancnuno · · Score: 5, Interesting

    Thai Ngoc or Hai Ngoc (born 1942) is a Vietnamese insomniac.

  15. 6 hours unusual? by citylivin · · Score: 4, Interesting

    "They then worked back to find out who provided the samples and found a mother and daughter who were naturally short sleepers. The women routinely function on about 6 hours of sleep a night; the average person needs 8 to 8.5 hours of sleep."

    A great documentary about this subject was from the Horizon program, entitled The Secret Life of Your Bodyclock. One of the things that they stated was some peoples body clocks run on different cycles. I believe they had examples of a 32 hour "day" clock and a 22 hour one and the differences that this placed on the subjects.

    The comment that i wanted to make was that there are probably lots of people who do not fit into the 24 hour lifestyle that we are forced into. The secret life of your bodyclock was very eye opening. They had all sorts of great stats on why you shouldn't exercise in the morning, that you should always consume alcohol between 6-8pm (local time) and a great section on why teenagers hate getting up. Its well worth the watch if you can find it somehow....

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  16. Let Me Guess... by lobiusmoop · · Score: 3, Funny

    The 2 people with the mutation work as a movie projectionist and a banquet waiter in a luxury hotel.

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  17. Re:Presence of Restoration Effects in These Subjec by Rogerborg · · Score: 3, Funny

    Uh... perhaps it's simply that it's beneficial to sleep (and use less energy) whenever you're not doing anything else? We sleep for about 8 hours because in equatorial Africa, there's about 8 hours of darkness when us vision oriented fruit-and-vegetarians monkeys can't find anything to eat or screw - I mean, who likes waking up in the morning next to a half eaten poison pear, or worse yet, a fugly skank monkey?

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  18. My name is Hiro Nakamura ... by Lemming+Mark · · Score: 3, Funny

    ... I have the power to control time - bedtime!

  19. Cellular repair, sanity? by phorm · · Score: 5, Insightful

    I wonder about the average level of sleep we get nowadays, how much we need as we age, sanity issues, and more.

    At the moment, sleep deprivation can lead to some nasty psychological issues. It says that the mice "recovered quicker from periods of sleep deprivation compared with regular mice", but does that mean that they just jumped to work quicker and less sluggishly, how about mental health? I'm guessing it becomes a quality VS quantity issue. I know that when my allergies act up, I don't breathe as well, and even though I sleep slightly longer durations I feel less rested than less sleep with clear sinuses. The breathing issues would then cause sleep-apnea related issues.

    Another thing I would like to see here is the "depth of sleep", such as REM, etc. If the gene actually modifies it so that the mice hit an optimal sleep depth more quickly, that might more sense. I've often found that if I consistently go without enough sleep I get sluggish, but sometimes if I really wear myself down, stay up really late, and then hit the sack when I'm just about ready to drop, I sleep *EXTREMELY* deeply and feel more rested on 3-4h of sleep than 7-8 hours. On people that get by very well on low sleep, I'd be willing to bet they measure a noticeably different EEG frequency (and possibly other factors such as blood-oxyen level), with a pattern more like a sharper curve towards deep sleep.

    This would indicate a "quality" issue rather than a quantity. It would also make sense in an evolutionary sense. Yes, longer sleep means perhaps a longer duration of potential vulnerability, but a longer less-deep sleep be trading depth for recoverability.
    E.G. if a large predator comes stomping up when you're at level 5/10 sleep, then you have a good chance of waking up and getting the f*** out of there even though you're out for approx 8h. Alternately, if you're out for a 3h super-nap, and at 9/10 depth for most of that, perhaps the potential for being gobbled up during that period is greatly increased?

  20. Boring, already done! by SolarStorm · · Score: 5, Funny

    The genetic mutation is called children. Guarentees less sleep for the parents.

  21. Re:X-Men by Goldberg's+Pants · · Score: 4, Insightful

    It is rather disturbing.

    Of course you know what will happen. They'll make it so people need less sleep so they can work longer.

    Not like they'll be allowed to spend their new awake time on leisure. "Hurray! We can now work people an extra 20 hours a week!"

  22. Re:Hypocrisy by Vexorian · · Score: 4, Interesting

    To the people in extreme poverty, I doubt there is much difference between a guy that walks with a gold stick and other that is able to pay and use for a computer, all the material inside (including some gold sticks) , and also the internet connection + infrastructure... Well, it is a blessing we just live reasonably this allows to both ignore the poor AND criticize the rich for not helping the poor, how lucky we are.

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