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Fully Functional Bioengineered Tooth Grown In a Mouse

A couple of weeks back the Wall Street Journal reported on the first organ grown in vivo from stem cells — a tooth in the mouth of a mouse. Reader cdrpsab spotted the news on the MedGadget blog; the research had been reported earlier in the PNAS. From the WSJ: "The researchers at the Tokyo University of Science created a set of cells that contained genetic instructions to build a tooth, and then implanted this 'tooth germ' into the mouse's empty tooth socket. The tooth grew out of the socket and through the gums, as a natural tooth would. Once the engineered tooth matured, after 11 weeks, it had a similar shape, hardness and response to pain or stress as a natural tooth, and worked equally well for chewing. The researchers suggested that using similar techniques in humans could restore function to patients with organ failure."

3 of 264 comments (clear)

  1. Human Pancreas? by JakartaDean · · Score: 4, Informative
    Mr. Scientist, if you happen to get around to doing something like this for a human pancreas, could I order one please? Blood type B+, if it's not too much trouble. DNA available on request.

    Yours sincerely,

    Dean, on behalf of millions of Type I diabetics

    P.S. I *love* hearing about this stuff. The potential for helping millions is incredible.

    --
    The subject who is truly loyal to the Chief Magistrate will neither advise nor submit to arbitrary measures (Junius)
    1. Re:Human Pancreas? by Cyberax · · Score: 4, Informative

      Yes, there are islet cell therapies on the horizon: http://stemcells.nih.gov/info/scireport/chapter7.asp

  2. Re:Strange Leap by alannon · · Score: 5, Informative

    Honestly, I don't think that calling a tooth an organ is very much of a stretch. Teeth have their own blood vessels and nerves, and consist of a large proportion of living tissue. This little blurb provides what I think is a convincing, if hardly exhaustive, argument that teeth are organs.