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Scientists Find Master Gene To Switch On Immune Cells

Scientists claim to have identified a master gene which is able to transform blood stem cells into disease-fighting immune cells. The hope is that this discovery will allow for new treatments for cancer. "The researchers have 'knocked out' the gene in question, known as E4bp4, in a mouse model, creating the world's first animal model entirely lacking NK cells, but with all other blood cells and immune cells intact. This breakthrough model should help solve the mystery of the role that Natural Killer cells play in autoimmune diseases, such as diabetes and multiple sclerosis. Some scientists think that these diseases are caused by malfunctioning NK cells that turn on the body and attack healthy cells, causing disease instead of fighting it. Clarifying NK cells' role could lead to new ways of treating these conditions."

2 of 94 comments (clear)

  1. Re:Cure for cancer... by ByOhTek · · Score: 5, Interesting

    The problem with "a cure for cancer", is that cancer isn't one disease. Also there are many causes.

    That being said, reliable treatments (cures) for different types of cancers can still be developed. However, no cure for cancer could ever prevent a relapse, unless it treated the genetic factors involved, and was taken regularly through a person's life. Even then, only cancers derived from the cause that the treatment targets, will be prevented.

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  2. Re:Cure for cancer... by Bakkster · · Score: 4, Interesting

    Ah, but these cells are the ones that normally prevent cellular mutations from becoming tumors. It's the body's own defense mechanism, and it works the vast majority of the time. If you can increase the number of NK cells, you increase the body's defenses against all forms of cancer, including relapses. In fact, this treatment would be especially good at relapses, since part of their purpose is to destroy individual cancerous cells before they can grow into tumors.
    http://en.wikipedia.org/wiki/Natural_killer_cell

    While there are obviously some hurdles, mobilizing the body's anti-cancer response enough to overpower tumors sounds like a cure to me.

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