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Aging Discovery Yields Nobel Prize

An anonymous reader writes This year's Nobel Prize in Physiology or Medicine is awarded to three scientists who have solved a major problem in biology: how the chromosomes can be copied in a complete way during cell divisions and how they are protected against degradation. The Nobel Laureates have shown that the solution is to be found in the ends of the chromosomes, called the telomeres, and in an enzyme that forms them."

4 of 187 comments (clear)

  1. Re:Sooo by cashman73 · · Score: 4, Informative

    Yes, you can be immortal if you want. But part of the problem is that, in order to achieve immortality, you have to keep adding guanines to your telomeres. The problem with that, is that it gives you cancer,... ;-)

  2. old news by Tim4444 · · Score: 4, Informative
    The summary makes this sound like a recent discovery but this has been known for some time. Also, it has more to do with cell aging than human aging. It's very important in cancer research since abnormal telomere activity is one of the factors in making cancer cells immortal (so to speak). They mention this in TFA. BTW, senescence is (naturally) programmed cell death:

    Most normal cells do not divide frequently, therefore their chromosomes are not at risk of shortening and they do not require high telomerase activity. In contrast, cancer cells have the ability to divide infinitely and yet preserve their telomeres. How do they escape cellular senescence? One explanation became apparent with the finding that cancer cells often have increased telomerase activity. It was therefore proposed that cancer might be treated by eradicating telomerase. Several studies are underway in this area, including clinical trials evaluating vaccines directed against cells with elevated telomerase activity.

  3. Re:Bio 101 by TheRaven64 · · Score: 5, Informative

    Nobel prizes are never awarded for new work, they are awarded for work you did sufficiently far in the past that it has been extensively peer reviewed and tested and is now accepted as being one of the bits of scientific knowledge that everyone in the field knows. This one is being awarded for work originally published around 1980 (as it says in TFA). Others have now tested this the published results in sufficient detail that it is now something that almost everyone with any awareness of biology knows.

    A Nobel Prize is not like a 'best paper in conference' award. You don't get it for new and exciting theories, you get it for theories that have withstood careful examination and testing. If the LHC finds a Higgs Boson then Peter Higgs will almost certainly get a Nobel, for the work that he did predicting it back in 1964.

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  4. Re:Sooo by randyleepublic · · Score: 0, Informative

    No, you activate telomerase and it does what it is designed to do - it repairs the telomeres by adding additional repeats. Your cells are no longer entering senescence, and are therefor much healthier - much more resistant to cancer and a host of other diseases.

    Of course the trick is how do you activate telomerase? We're working on that!

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