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Nanomedicine Kills Brain Cancer Cells
destinyland writes "Scientists from the University of Chicago and the US Department of Energy have developed the first nanoparticles that seek out and destroy GMB brain cancer cells. Nanoparticles killed up to 80% of the brain cancer cells after just five minutes of exposure to white light, showing the promise of nanomedicine — highly-specific intervention at the molecular scale. Because nanomedicine could repair brain cells or damaged nerve and muscle tissue, the NIH has established eight Nanomedicine Development Centers around the country for their Nanomedicine Roadmap Initiative. Researchers have also used gold nanospheres to search out and 'cook' skin cancer cells with light — 'It's basically like putting a cancer cell in hot water and boiling it to death,' says one researcher. And the NIH Roadmap ultimately predicts 'novel tiny sensors ... that search for, and destroy, infectious agents.'"
Is it just me or will we be seeing a video game loosely based on this soon ? Sort of ender-esque
errr....umm...*whooosh* *whoosh* Is this thing on ?
Nanoparticles killed up to 80% of the brain cancer cells...
Awesome!
...after just five minutes of exposure to white light
Wait. What? So much for non-invasive.
Great! Now The government can simply kill off the specific brain cells they find responsible for independent thought!
Defective Logic
"We are Borg. You will be assimilated. Resistance is futile."
Encryption: I may not agree with what you say, but I will defend your right to encrypt it...
Nanoparticles killed up to 80% of the brain cancer cells after just five minutes of exposure to white light
Side effects may include death of 80% of non-cancer cells.
I, for one, salute our new nano-particle overlords...
--- Asking inconvenient questions for over 30 years...
Wish I had the mind for the science involving any of the nano industries. It's starting to look more and more like it's going to be my generations plastic.
I read the title and thought, don't we already have substances to do this for us?
If there's even been a story that needed this tag, this is it.
Every time I read one of these "nanoparticle medicine" articles I can't help but wonder of the manufacturing processes necessary for the medicine have been developed. I get the impression that alot of these nanoparticle treatments are crafted with such great care that no manufacturing process could hope to reproduce them in the quantities necessary for real-world use. Where's the slashdot article covering the research needed to develop manufacturing processes for these nano-particle treatments?
The article states that "cultured human GMB cells" were "killed up to 80 percent... after 5 minutes of exposure to focused white light".
How exactly are you going to expose a malignant tumor that has diffusely infiltrated the parenchyma of the brain to focused white light? You can't surgically resect a GBM unless you are willing to remove an entire cerebral hemisphere. If you scooped out part of it and exposed the remaining cavity to white light you would barely effect any of the remaining tumor.
Now if brain tumors only occurred in petri dishes then this treatment would result in a brief remission.
Wish they had things like this when my wife was diagnosed with a glioblastoma multiforme four years ago. One afternoon, six weeks after diagnosis, she said she was sleepy. We said "I love you" and shared a kiss before she fell asleep. Later that afternoon, swelling around the tumor herniated her brain stem. She never woke up and died in my arms one week later. Twenty years together. I miss her every day and I don't think I'll ever recover.
Love the people in your life like there's no tomorrow. (We were lucky.)
P.S. For you Googlers, the more common abbreviation is GBM.
It must have been something you assimilated. . . .
Seriously, we always read on Slashdot the great experimental breakthroughs, but we never really see the applications and doctors don't even know what is wrong with you half the time. Most of the problems I have had and saw a doctor for, they had no real clue what he problem was. Only later did I realize myself what caused the issue, like a certain food or allergic reaction. Medical practioners can't even tell if you have a virus or a bacterial infection, and instead just prescribe antibiotics because the patient demands it (blood tests for this are only semi-accurate, and can give false positives and negatives).
When are we going to see some real "in office" diagnostic technology, or is this just not going to happen in our lifetime?
We saw a headline that said "Nanomedicine Kills". So we shouldn't have anything to do with that, now should we?
This issue is a bit more complicated than you think.
Nanoparticles killed up to 80% of the brain cancer cells...
Team these nanoparticles with some microbrews for the ultimate in killer brain food.
How do you salute something inside your own head?
It won't work.
Having worked on glioblastoma for a major pharma company, I'm quite confident that this is garbage. There's already very nice cures for glioblastoma if you're treating it in a dish... most notably a protein named BMP4. The problem is, you can't deliver it to the brain. If you can't effectively deliver a protein to the brain you're sure as hell not going to be able to shine visible light on the author's fancy nanoparticles in order to activate them in vivo.
99.99% of the non-cancer cells were obliterated too!
Looks like an "Obama"-ized solution to global warming. Ergo, just kill everyone. No People, no global warming.
--9
You have a precious memory, and your experience serves as an example.
My mother had lung cancer four years ago. It woke me up to exactly what you said in your post. I left Silicon Valley, and moved back to my rural roots.
Three weeks after I got back, Mom nearly died of anaphylaxis brought on by an allergic reaction to her chemo. As I watched the oncology staff race to save her, I knew that I had made the right choice.
Today, Mom is doing well, and I relish being with my family, even when we annoy one another.
Let us see you need white light. No they really need Near-UV light, cause that's what TiO2 Nanoparticles absorb and create free radicals (things that actually kills cells), and since UV doesn't penetrate tissue that well this will only affect the surface tumor cells. Moreover, this UV light will cause damage itself. And only 80% that leaves 20% still around. As an idea, this is stupid and only good for publication. I which the NIH/NSF would stop wasting money on such research. Spend on more fruitful cancer research like small molecule drugs, programed bacteria/virus and more practical nanodrugs. Not this sensetional nonesense that gets the public hopes up, when in reality it going no where.
If there's one thing I've learned in my life, it's that no one can predict one's reaction to mortality, whether one's own or someone else's. Some can pick up and go on, others can't, and there's no way to tell who is wired which way, until the reality hits.
Hopefully, you can come to understand this before you need others to understand this of you.
your skull
First slashdot post to bring a tear to my eye.
I hope this method actually works. That wiki article mentions that there is some evidence of stem-cell like cells in GBM. Numerous treatments in other types of cancers have been able to destroy most cancer cells, but the stem cell population in many cancers is thought to be more resistant to those drugs, and therefore the minority of cells that treatment doesn't kill quickly seed new cancers. Most of those treatments though seem to focus on affecting cell division. The thinking as I've heard it is that cancer stem cells divide slower than other cancer cells, so they're less susceptible to it. This treatment though doesn't necessarily.
So while 80% isn't that high, that might be better than it sounds, because it might not be biased against destroying the cells you really want to destroy.
Many people DO report seing a white light as they're about to meet their creator... Now if it were black light... well I guess it would kill 100% of the tumor (as well as a very good portion of colateral damage).
My sig is better than your sig.
If you peel off all the intact brain cells in order to shine light on the cancer, you might as well remove the cancer cells manually. And be sure to put the intact cells back intact after you are done with your flashlight.
.. you'd get confusion: is this person already dead or it is still the BSOD glow?
Insert
The individual who submitted this item and the /. editor who approved it should be accused (and presumably flogged) for spreading buzzworditis. We have had "nanomedicine" using the definition of "medical intervention at the molecular scale for curing disease or repairing damaged tissues" (using sub-100 nm particles) since the discovery of penicillin 80+ years ago (and even earlier if you count some less well known drugs). The only thing offered by most current "claims" of nanomedicine involve more focused targeting, usually using antibodies combined with some focused radiation (heat, light, etc.) and is only the result of the fact that we have a somewhat greater knowledge of which proteins may be more highly expressed by cancer cells combined with somewhat less toxic radiation therapies (IR or visible light vs. X-rays). There isn't anything "new" here. This is simply a refinement of what we have been doing for 30 or more years. If you wanted to call this "nanomedicine" then you should also call the use of the chemotherapeutic drug "Gleevec" (which is now 8 years old) "nanomedicine".
I was at the conference in the early part of this decade when NIH announced to great fanfare that it was launching a program involving "nanotechnology" and "nanomedicine". It was clear at the time that they didn't know what they were doing (and I stood up in the NIH auditorium and told them so -- and pointed out that they would have to read Drexler & Freitas before they would reach that point). They have gotten somewhat better but by and large they are still doing more of the same (which is a well known problem with the standard medical grant approval research process -- one gets approved by making small incremental improvements, not by really innovating). As a result what goes by the name of "nanomedicine" is really nothing more than fancy chemotherapy.
It should be noted that we came much closer to real nanomedicine in the 1990's when there was a lot of activity with gene therapy research. Unfortunately due to a few deaths and the FDA squashing such efforts, gene therapy research is largely at a standstill. The work by Sangamo and others is making slow progress but it could have been much further along by now (we could have had virus based "limited intelligence" therapies that would sense what cells are cancerous and caused them to commit suicide).
Cancer and aging are both very simple. In terms /.'ers will appreciate, "the code becomes corrupted". Cancer is a subset of aging in that a specific subset of the genome (involving those genes regulating cell replication and migration) become corrupted. To fix these problems you have to eliminate the bad code and replace it with good code. In theory what chemotherapy and radiation therapy attempt to do is eliminate the bad code (but grossly -- think using an atom bomb when one would like to use a precision implosion to bring down a Las Vegas hotel). Replacing the cells with good code is what stem cell therapies (if one could use pristine stem cells -- those with unmutated/unaged genomes) would do. Even better would be using bacteria sized nanorobots to scan the code and fix the errors. That is what Robert Freitas has envisioned "chromallocyte" nanorobots doing. But their implementation is so far from the limited NIH vision of "nanomedicine" (think going to the moon vs. launching a bottle rocket in ones back yard) that it is a gross abuse of the term "nanomedicine" when used to describe enhanced chemotherapy.
Now, for those few who are nanoliterate among the readers... Drexler described a nanoassembler in 1992 (in Nanosystems). Freitas mentioned chromallocytes (and what they could do) in 1999 (in Nanomedicine V I and in more detail in a subsequent technical paper). Drexler and Merkle designed ~5000 atoms of a 4-8 million atom nanoassembler in the 1993 time frame (it took several person-months). We now have supercomputers capable of molecular simulations of nanoassemblers (the ribosome was simulated at Los Alamos in ~2003). After the design and simulate stages one has the build, assemble and test stages. No different from what we have been doing with cars and planes for decades. But we will not get there by seeing if we can build better bottle rockets.
You think like a ReThuglican Jew
No, his refusal to click on it shows that he knows about the claim that Seigenthaler killed Kennedy, which stood for months; the guy named Essjay who was put into powerful positions on Wikipedia after claiming he was a religious scholar even though he was a kid who was frankly a waste of carbon, and who was defended by Wiki-overlord Jimbo Wales even after it was clear what had happened; the man who was detained at Canadian customs because of false information in his Wikipedia entry; or any of the other billions of things that show that Wikipedia is a complete disaster and that human knowledge is made less, not more, by its existence.
Wikipedia has actual negative impacts on real people and is run by people like Essjay who really aren't fit to be sweeping streets, and attempting to defend it makes you look like a fool.
What a waste of money. Vitamin D reduces cancer to background noise. Getting rid of chicks' bras gets rid of most of the rest.
Time to change my sig.
- Just trying to survive until the nanobots make me immortal -
> 'It's basically like putting a cancer cell in hot water and boiling it to death,'
Could we get a 'brainsoup' tag over here please?
Thankyou.
GBM. Not GMB.
This is not intended to be a nitpick, but rather out of respect of the people who have it, we can at least abbreviate the disease correctly.
It is terrifying.