Slashdot Mirror
Facial Bones Grown From Fat-Derived Stem Cells
TheClockworkSoul sends in an article up at Scientific American, from which we quote: "Stem cells so far have been used to mend tissues ranging from damaged hearts to collapsed tracheas. Now the multifaceted cells have proved successful at regrowing bone in humans. In the first procedure of its kind, doctors at Cincinnati Children's Hospital Medical Center replaced a 14-year-old boy's missing cheekbones — in part by repurposing stem cells from his own body. To create the new bones, which have become part of the patient's own skull structure and have remained securely in place for four and a half months, the medical team used a combination of fat-derived stem cells, donated bone scaffolds, growth factors, and bone-coating tissue. The technique, should it be approved for widespread use, could benefit some seven million people in the US who need more bone — everyone from cancer patients to injured war veterans."
The question of whether we can do "just about everything with adult stem cells" is still quite open.
Could we get more funding dedicated to stem cells if we required that it all be used for adult stem cell research? Yes. Would that accelerate the overall pace of advances in stem cell research? Quite possibly not. There are two different games right now: the first is to see what we can do with stem cells (this is largely being done with embryonic stem cells). The second is to see how we can make adult stem cells behave like embryonic stem cells. The second game feeds back into the first. Indeed, if we get good enough at the second, we will no longer need embryonic stem cells, and we can then focus all of our energies on seeing what we can do.
If and when we get really good at extracting or reprogramming adult cells to behave like embryonic stem cells, we will also have the side benefit of not having to worry about alloimunity (tissue rejection). For example, in the particular case being discussed here, the fear of alloimmunity was probably a key reason for making the effort to use the patient's own cells. In the meantime, from a scientific perspective, it is prudent to continue to invest in both embryonic stem cells and in research towards no longer needing embryos from which to harvest these cells.
This technique will be a great boon for people with a massive amount of dental damage - where the jaw has been eaten away from disease, or injury has made it impossible to even use dentures. It'll likely be expensive for a long time, but for people who are facing a life of eating through a straw, and having massive facial deformities, this would be a huge change in their lives.
Why can't I mod "-1 Idiot"?
At the least, we need to know if we can replicate fully the features and functions of embryonic stem cells. We'll need embryonic stem cells for that purpose alone. If adult stem cells don't work completely like embryonic stem cells, that means that we may need a supply of embryonic stem cells indefinitely as well.