Slashdot Mirror
The Mass Production of Living Tissue
An anonymous reader sends in this moderately disturbing quote from Gizmodo:
"I'm touching a wet slab of protein, what feels like a paper-thin slice of bologna. It's supple, slimy, but unlike meat, if you were to slice it down the center today, tomorrow the wound would heal. It's factory-grown living tissue. The company behind the living, petri-dish-grown substance known as Apligraf hates my new name for it: meat band-aid. 'It's living,' Dr. Damien Bates, Chief Medical Officer at Organogenesis, corrects me. 'Meat isn't living.' But no one argues with me that this substance is really just a band-aid. A living, $1500 band-aid, I should say. Apligraf is a matrix of cow collagen, human fibroblasts and keratinocyte stem cells (from discarded circumcisions), that, when applied to chronic wounds (particularly nasty problems like diabetic sores), can seed healing and regeneration. But Organogenesis is not interested in creating boutique organs for proof of concept scientific advancement. They're a business in the business of mass tissue manufacturing — and the first of its kind."
Many a SciFi story I've read has used this kind of thing for wounds. I wonder how soon until they have it to the point where these slices are vacuum packed and you can open it and stuff it into a wound in the field?
If brevity is the soul of wit, then how does one explain Twitter?
So when you rub your scars you induce swelling!
Tsunami -- You can't bring a good wave down!
how does it taste?
...this tech will finally deliver fully realized COTS pornstar-branded vaginas. At which point the world will end.
This sounds like incredibly great news for burn victims, given development.
Pathological kinda promises Path + Logical - but instead, you get stuck with pathetic.
This sounds highly promising for traditionally traumatic and fatal wounds, particularly burns. It will be interesting to see if this product increases the rate of survival in burn victims and other similar traumas. You have to love modern medicine.
I don't get why this is news. This company and this product have been around for like 20 years.
Soylent Green is Wankers!
Table-ized A.I.
Band-Aid®?
Some days it's just not worth
chewing through my restraints.
The hospital in question was using disused foreskin to create eyelids for burn victims. Alas, they all turned out to be cock-eyed after the procedure!
but unlike meat, if you were to slice it down the center today, tomorrow the wound would heal.
Yeah, because there never even was a animal who cut itself, and where then the wound healed...
FAIL
That would be called a fleshwound. A wound to its flesh or tissues. Meat is the same tissue, but terminally locked into 'deadness'.
There is a difference.
Sounds really promising for those who want to be cannibals. Just grow it using samples from your tastier friends (or from yourself, for the ultimate: survivable self-cannibalism). The price might have to come down a little, of course, or it will remain an expensive delicacy.
Those who can make you believe absurdities can make you commit atrocities. - Voltaire
I am not sure why this item was introduced as "moderately disturbing". If you will permit me, I will explain what it is, since I use it regularly. (I have no stock nor other biased affiliation with the company or product.) The product first came on the market in 1998, over 10 years ago. It has a well-established place in the treatment of chronic wounds. It is not the only product in the category of "living cell therapies" for chronic wounds. The other product is Dermagraft, similar, and likewise around for nearly 10 years. When Apligraf first came out, it was promoted as skin-graft-in-a-box. It is not. It is allogeneic material (recipients will reject it), and thus it does not "take" to the body like an autogenous skin graft. In its earliest years, when the company was promoting it as a skin graft, it got some high profile press because it was put to good use as readily available biological coverage for burn victims of the 9-11-2001 twin towers catastrophe. The company that makes it, Organogenesis, partnered with pharma giant Novartis for marketing and product management, and under them, they listened to customers who told them it was not skin grafts in a box, and they redefined its marketing for chronic wounds. The product management has been back in the hands of Organogenesis for about 3 or 4 years now.
The material is essentially a poly-pharmaceutical packaged in a living material. The raw materials come from donated foreskins. Extensive safety testing is done. Pure extracted fibroblasts are put into cell culture, where they do their business and re-form a collagen matrix equivalent to normal dermis. After that, pure keratinocytes are cultured on top of the dermis, and an epidermis forms. The product is shipped in its petri dish, as a circle of 44 sq cm area. The Gizmodo article shows a picture of it. As a living material, its procurement and handling are a bit different than most medical devices, but it is easy to get and apply.
The juvenile cells in the material make a broad spectrum of growth factors and other biochemicals which have a positive pro-proliferative effect on wounds. The role for this material is for chronic and pathological wounds. The company got its market approval and indications from the FDA for studies done on diabetic and venous ulcers, but the material is useful for chronic and pathological ("cap") wounds of any cause. Like anything else, it does not work for all wounds or patients, but it is fairly predictable, and its results can be rather dramatic. When a cap wound of whatever cause has been treated to the point that disease is quiet, inflammation is gone, and the wound should be healing but it is not, then that is when wound stimulatory therapies are applied. There are several available, and Apligraf has been one of the flagship products in this category for 10 years now. Many wounds which simply will not budge no matter what will take off and heal once this is applied.
Organogenesis has its first new product coming out soon, for oral mucosa and gingiva, so perhaps that is why they are trying to stir up some attention with articles like the one quoted. However, it is not Brave New World nor Coma nor any other meat factory. It is just on the leading edge of biological therapeutics in the 21st century. And if Slashdotters want to make lots of jokes as they often do, like "put Viagra in the petri dish to grow more", well, we've already heard them all.
(All very timely, since I just gave a presentation on this last week (and have been for 8 years). If you want to learn more, I posted a copy of the presentation on the website I use for posting talks and presentations and whatnot. This particular talk has a mix of my slides and company slides. It is NOT yet annotated with full text on each slide, so some will just be pictures and you will have to infer what you can, but text should be coming one of these days:
http://www.arimedica.com/content/arimedica_apligraf_(partially%20annotated)_2005-1006.pdf
Again, I have no investment nor bias here, I just use this stuff in practice because it works and it's an important product.)
I think that circumcision had been around a few years longer then this product. So you want people to be in pain longer and possible die instead of using some tissue that is going to be discarded anyway? I never understood why people are so against circumcision. If I could meet the doctor who did mine, I would shake his hand and say "Good Job, chicks love my cock"
I never understood why people are so against circumcision.
I don't think many people are against circumcision per se -- if you want one, have one. What people are against is forcibly circumcising people who did not agree to be circumsized.
I don't care if it's 90,000 hectares. That lake was not my doing.
...it's a real growth industry.
-- thinkyhead software and media
So what's the big deal, boys are going to be circumcised anyway, why not profit from it?
It's the profit motive that's the problem.
Parents report being pressured by hospital staff to circumcise their newborn sons. In fact, the anti-circumcision organization IntactAmerica.org was originally funded by couple in response to their disgust at having been pressured to have their boy cut.
Infant boys' foreskins may be very valuable to tissue engineering companies but they are more valuable and rightfully belong to the boys themselves.
Infant circumcision is an unnecessary amputation that cannot be refused by the prospective amputee himself. That makes it a forced amputation, a very serious human rights violation.
Circumcision advocates within the CDC are now pushing to get the agency to endorse circumcision as an HIV preventative. Sounds great, but if you read further there is no real claim of effectiveness. You still have to wear a condom if you want to be actually protected from infection. The circumcision-HIV experiment has already been conducted on a mass scale and the result was negative. America has the highest circumcision rate in the developed world and also the highest HIV rate. Perhaps that's why circumcision advocates are careful to say that you still need to wear a condom. Being cut is simply of no use in fighting HIV.
So why push parents to have their baby boy cut when it's not going to protect him from anything?
Follow the money. Amputating infant foreskins is a billion dollar business. And now someone else wants his foreskin, the tissue engineering companies.
The mass production of living tissue would be a fine development if it didn't depend on infant foreskins. Treating non-consenting minors as a source of spare parts violates our most basic ethical standards.
That's ok think of the foresight they'll have!