Slashdot Mirror


Scientists Measure How Quickly Plant Genes Mutate

eldavojohn writes "A recent study puts observed numbers on genome mutations in plants. This kind of research is becoming more popular in understanding evolution. The research 'followed all genetic changes in five lines of the mustard relative Arabidopsis thaliana that occurred during 30 generations. In the genome of the final generation they then searched for differences to the genome of the original ancestor.' A single generation has about a one in 140 million chance of mutating any letter of the genome (which has about 120 million base pairs). Sound like bad odds? From the article, 'if one starts to consider that they occur in the genomes of every member of a species, it becomes clear how fluid the genome is: In a collection of only 60 million Arabidopsis plants, each letter in the genome is changed, on average, once. For an organism that produces thousands of seeds in each generation, 60 million is not such a big number at all.' The academic paper is available in Science, though seeing more than the abstract requires a subscription."

10 of 67 comments (clear)

  1. evolution ? by polar+red · · Score: 5, Insightful

    Plants don't evolve, they get changed by the touch of his noodly appendages

    --
    Yes, I'm left. You have a problem with that?
    1. Re:evolution ? by Maxo-Texas · · Score: 4, Insightful

      Bonus points for introducing a second unrelated hot topic.

      What I want to know is the impact of gay marriage, and dating co-workers on all this.

      --
      She was like chocolate when she drank... semi-sweet at first and then increasingly bitter.
    2. Re:evolution ? by polar+red · · Score: 5, Insightful

      It's funny the people warning us about one world (elected)government don't issue warnings about our (unelected)corporate overlords.

      --
      Yes, I'm left. You have a problem with that?
    3. Re:evolution ? by polar+red · · Score: 5, Informative

      Scientists are always trying to disprove. 'proving' a new theory is much harder than disproving the most widely adopted theories. see 'falsifiability' http://en.wikipedia.org/wiki/Falsifiability

      --
      Yes, I'm left. You have a problem with that?
  2. Enough Already ! by daveime · · Score: 4, Insightful

    The academic paper is available in Science, though seeing more than the abstract requires a subscription

    I thought this was "news for nerds, stuff that matters", not "Science magazine touting for subscriptions".

    If we can't even RTFA without paying first, then it has no place on this site IMHO, as we have all come to realize that TFS is at best "a summary", and at worst, complete BS.

    1. Re:Enough Already ! by RDW · · Score: 4, Funny

      Sounds like you might be interested in this exciting new media access concept!:

      http://en.wikipedia.org/wiki/Library

    2. Re:Enough Already ! by Daniel+Dvorkin · · Score: 4, Insightful

      Slashdot regularly reports on new products costing hundreds or thousands of dollars, sometimes tens of thousands. You don't get to use the product (particularly if it's hardware) without paying for it, yet many more people will talk about it than will pony up the cash.

      If you want to read the article without a subscription, you can do so for fifteen bucks. If you're in school, or know anyone who is, there's a good chance you can do so for free.

      For those of us in bioinformatics, this kind of thing is our bread and butter. Don't dismiss this as "not news for nerds" just because it doesn't happen to relate to one of the particular kinds of nerdiness about which you care enough to pay a small amount of money.

      --
      The correlation between ignorance of statistics and using "correlation is not causation" as an argument is close to 1.
    3. Re:Enough Already ! by daveime · · Score: 5, Funny

      Morpheus

      This is the construct. It's our loading program. We can load anything from clothing, to equipment, weapons, training simulations, anything we need. But if you want to read a Science article linked from Slashdot, you'll have to get on the bus and nip down to the local library.

  3. Re:Oh great. by bcmm · · Score: 5, Insightful

    Genetic diversity is useful, as it make it much harder for a single pathogen to wipe out a population in a short space of time.

    As for the rest, nobody is going to claim that each individual is a species. You've constructed a rather unconvincing straw man to hijack an interesting article, because you have a problem with some imaginary "greenies".

    --
    # cat /dev/mem | strings | grep -i llama
    Damn, my RAM is full of llamas.
  4. Great piece of work! by elyons · · Score: 5, Informative

    For those that don't know much about either the significance of the science or the technology involved with generating the data, this might be useful. One big gray area in our understanding of evolution is how quickly genomes are changing, where they change, and the types of changes that are occurring. Yes, a genome is usually made up from DNA (RNA viruses being the major exception), and encoded in the DNA are genes, many of which get translated into proteins that do much of the "work" in an organism. However, depending on the organism, much of the DNA does not code for genes. The human genome for example is ~3,100,000,000 nucleotides (DNA's building blocks) long. Of that, ~1.5 percent codes for protein. Of the rest, the vast majority are ancient, dead, "selfish" chunks of DNA such as retroviruses (RNA viruses that convert to DNA and integrate into a genome. HIV is an example of one of these guys) and transposons (a major class of which are just like retroviruses but lack the genes for cell-to-cell transfer). Periodically in the evolution of many multicellular organisms (e.g. plants and animals), there are explosions or blooms of these types of elements that suddenly take off and integrate around a genome. This is one type of mutation (or genome evolution), and there are many others. Single nucleotides can change (e.g. C->T, as discussed in the paper), individual genes can get duplicated through a process known as unequal crossing-over or nonhomologous recombination, and the entire genome can be duplicated (known as polyploidy and is a dominant feature in flowering plant genome evolution.)

    Our current understanding of how dynamic a genome is, the types of changes that occur, and the factors that limit these changes is very limited. Much of this is because getting a genome of an organism can be expensive and laborious, depending on the size of the genome (RNA virus 15,000 nt, DNA virus: 150,000 nt, bacteria: 5,000,000 nt, yeast: 20,000,000 nt, multicellular organisms: 100,000,000-10,000,000,000). Since our understanding of how genomes evolve depend on getting genomes sequenced that are appropriately related to one another (e.g. populations of organisms versus diversity of organisms), we can only get answers for those genomes we currently have (current ~8000 for all viruses, bacteria, archaea, and eukaryotes). Fortunately, there is currently a major technological revolution happening in biology: generating DNA sequences fast and cheap. For example, the first human genome was approx a 10 year project and cost ~$1,000,000,000. Now, the record for a human genome takes less than a week and costs ~$15,000.

    This project is a major milestone as the authors sequenced 6 plant genomes (a mustard known as Arabidopsis thaliana) that are related to one another by 30 generations. Because of the close evolutionary relationships of these organisms, the authors can characterize the types of genomic change happening over very short time periods.

    The emerging picture is that genomes, the fundamental genetic blueprint for a lineage of organisms, are much more dynamic than we had previously thought.