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8% of Your DNA Comes From a Virus

An anonymous reader writes "About 8 percent of human genetic material comes from a virus and not from our ancestors, according to an article by University of Texas at Arlington biology professor Cédric Feschotte, published in the Jan. 7, 2010 issue of Nature magazine."

22 of 478 comments (clear)

  1. Useful? by Kolie · · Score: 5, Interesting

    Is any of that DNA in use or are those parts dormant? What effect do these modifications have on us beyond the initial use of replication and further propagation of viruses?

    1. Re:Useful? by tomhudson · · Score: 5, Insightful

      The weird thing is that research is now showing that a lot of the so-called "junk dna" is actually used indirectly. Maybe we like junk food so much because we eat what we are? :-)

      But this whole thing isn't all that surprising when you consider where our mitochondria came from.

    2. Re:Useful? by Anonymous Coward · · Score: 5, Insightful

      "The viral DNA that isn't conducive to death probably stayed in." -- There, fixed that for you.

    3. Re:Useful? by vadim_t · · Score: 5, Insightful

      How would they know?

      Hero of Alexandria didn't have trains in mind when he made his Aeolipile. It was used as a fancy way to open temple doors. Only much later people figured out a practical use for it.

      Boolean algebra was a very obscure branch nobody cared about until it suddenly became very useful.

      Lasers, IIRC didn't have an immediate application when they were invented. They definitely didn't have DVD drives in mind.

    4. Re:Useful? by icegreentea · · Score: 5, Interesting

      Apparently a lot of the ERVs (that 8% of our DNA made from retrovirus pieces) get expressed during pregnancy by the fetus. One of the results is that the mother's immune system gets depressed (apparently a lot of HIV-like stuff going on there) that prevents the mother's immune system from killing the fetus. There's probably lots of other fun stuff going on that we don't know about yet. It's actually really cool when you think about it... mammalian childbirth being possible because some immunodepressent virus infected some reptile a long long time ago.

    5. Re:Useful? by corbettw · · Score: 5, Insightful

      I am a pretty smart guy who doesn't understand the utility of pure research.

      One of these things is not like the other, one of these things just doesn't belong!

      --
      God invented whiskey so the Irish would not rule the world.
  2. Like my PC by Krneki · · Score: 5, Funny

    8% of my Windows code comes from Viruses.

    --
    Love many, trust a few, do harm to none.
  3. Revelation by schmidt349 · · Score: 5, Funny

    I'd like to share a revelation that I've had during my time here, Mr. Malda. It came to me when I tried to classify your species and I realized that you're not actually mammals. Every mammal on this planet instinctively develops a natural equilibrium with the surrounding environment but you humans do not. You move to an area and you multiply and multiply until every natural resource is consumed and the only way you can survive is to spread to another area. There is another organism on this planet that follows the same pattern. Do you know what it is? A virus. Human beings are a disease, a cancer of this planet. You are a plague and we are the cure.

    1. Re:Revelation by ElectricTurtle · · Score: 5, Interesting

      To be pedantic, the difference between humans and animals is usually called reason, but in fact it's probably more specific if less poetic to call it 'problem solving'. Animals don't 'live in equilibrium' per se because that implies that they know what they're doing, as though they're thinking 'oh... I'll eat exactly this much and no more because that will mess things up!' Pfff I'll bet somewhere there's some green whackjobs who think that's exactly the romantic notion going through the brains of animals. (In fact, there are predators that kill even after they are full, just to kill. I remember watching a documentary about sea turtles and watching them hatch and try to make their way to the sea, and predatory birds were attacking them, first to eat them, but even after that they just kept killing and leaving the dead baby turtles there to rot.) Anyway, I'm rambling, point is, animals expand as far as they can. They consume as much as they can, whenever and where-ever they can, and reproduce as often as possible. What determines their numbers ultimately are things like the rate at which their consumed resources replenish and the rate at which they otherwise die from predation/disease/accidents/age, not some kind of instinctive population control.

      So the contrast is, an animal, insofar as it thinks, thinks 'I will eat x' and then when x is scarce it thinks 'oh shit there isn't enough x!' Then depending on luck, it dies. Whereas humans think 'I like to eat x' and when x becomes scarce humans think 'well, this sucks, there isn't enough x anymore. Maybe I can eat something else? How about this? Ew. No, not that. How about this other thing? Meh, it's ok. Maybe I can cook it? What things could I do, or do in concert with others, that might restore the natural abundancy of x and/or allow x to be produced in an environment I control?' Yeah. That's why human population keeps growing, moving, adapting, and animals just have to suck it up. They can't solve resource problems creatively.

      (Viruses aren't creative either, they and other micro-organisms just have such fast life cycles that it allows them to find mutations that positively affect their survival at a higher rate. In other words they adapt quickly by chance, humans adapt quickly by decisions.

      --
      I support the Slashcott and will not be reading or commenting from 2/10/14 to 2/17/14. Beta is steaming pile of dog shit
  4. Poor Summary by Dr.+Eggman · · Score: 5, Interesting

    The real news here doesn't appear to be that endogenization has occured through our past (OK, maybe the 8% number is news; I don't know about the numbers...) but instead that a virus, bornavirus, is displaying this property. This is news because bornaviruses are not retroviruses (previously the only know virus-types to produce endogenous copies.) Furthermore, the article seems to suspect that this virus may have ties to the schizophrenia and mood disorders...

    --
    Demented But Determined.
  5. Re:But I use antivirus!!!! by Krneki · · Score: 5, Insightful

    It does, but as a side effect you are unresponsive 80% of your time.

    --
    Love many, trust a few, do harm to none.
  6. Re:Bible Code? by 2short · · Score: 5, Insightful

    "Any sufficiently large set of information is going to give you some matches on just about anything you search for."

    Yes, but not a sufficiently large rate of matches. If the researchers are competent, they can calculate what percent of the data would be expected to match their search even if the data is just random, and decide if the match rate exceeds that by a significant margin. The 'researchers' of the Bible Code were clearly not competent in exactly this way.

    As opposed to the paperback book market, Nature does not tend to print whatever comes across it's desk.

  7. Mammals by Anonymous Coward · · Score: 5, Interesting

    Google for placenta and endogenous (as in endogenous virus). The placenta uses a lot of viral code, to the extent that it might be more virus than anything else. It also sheds a lot of viruses. The placenta is almost a different life form.

    BTW, the Wikipedia entry shows that the "8%" number was known as long as 6 years ago.http://en.wikipedia.org/wiki/Endogenous_retrovirus

    1. Re:Mammals by MightyMartian · · Score: 5, Interesting

      ERVs have been known about for some time and are, in fact, one of the "killer" evidences for evolution. You can actually trace lineages with these genes, and they are useful for dating the splits between related lineages. For instance, chimps and humans share more ERVs than, say, humans and baboons. It's difficult to support that observation via Creationism, unless you proclaim the insipid "that's the way God wants it", but evolution explains it very neatly.

      --
      The world's burning. Moped Jesus spotted on I50. Details at 11.
    2. Re:Mammals by canajin56 · · Score: 5, Funny

      "That's the way God wanted it" isn't the only way to support the observation of genes existing in multiple species, in a way that seems to imply inheritance. How about "God made life using OO programming"? Why would he start from scratch for every species, instead of just using copy & paste? If you really think about it...hacked together in 6 days, spaghetti code where 80% seems to be junk that doesn't even do anything, and is incredibly hard to decipher...God made us in PERL! Perl supports multiple inheritance, which explains the appearance of "viruses" transplanting genes from one species to another, unrelated species!

      --
      ASCII stupid question, get a stupid ANSI
  8. Re:Summary and article misleading by IronDragon · · Score: 5, Insightful

    Much like someone who copies the content of their old computer straight over to a new computer every few years. Repeat this process a few billion times, and you'll be quite surprised at the amount of sheer useless crap that just keeps getting copied. Voila! DNA.

  9. Re:Not Bad by je+ne+sais+quoi · · Score: 5, Insightful
    Unless of course it's the 8% that makes you bald as you get older, or makes you susceptible to heart disease or diabetes, or any number of inherited undesirables. Remember, things like sickle cell anemia originated as a defense against malaria. In fact, in TFA it actually suggests an hypothesis:

    "These data yield a testable hypothesis for the alleged, but still controversial, causative association of BDV infection with schizophrenia and mood disorders," Feschotte said.

    where BDV here is the virus whose DNA they were searching for in the human genome. There you go, if you're depressed, manic or schizophrenic, it could be one of your ancestors got a brain virus.

    --
    Gentlemen! You can't fight in here, this is the war room!
  10. Re:Ob. Matrix quote by ShieldW0lf · · Score: 5, Funny

    The moral of the story is, cannibalism really does allow you to take your enemies strength. That's why we eat Jesus' flesh on Sundays, so we can absorb his holy virus and become like God.

    --
    -1 Uncomfortable Truth
  11. Re:Ob. Matrix quote by Anonymous Coward · · Score: 5, Funny

    That's why I eat copious amounts of pasta, so that I, too, may be touched by His Noodly Appendage.

  12. Re:Ob. Matrix quote by spun · · Score: 5, Funny

    Commit yourself daily to serving The Lord

    With some fava beans and a nice Chianti, fthfthfthfth.

    --
    - None can love freedom heartily, but good men; the rest love not freedom, but license. -- John Milton
  13. Re:Ob. Matrix quote by AmberBlackCat · · Score: 5, Insightful

    Ahhh religion, where changing flesh into bread and blood into wine isnt considered "witchcraft". Yet all other "magics" was at one time punishable. Hypocrisy, it loves religion.

    And Slashdot, where every story about biology turns into an attack on Christianity or some other faith. Things were different in the Pit & the Pendulum days, but lately it seems like you attack them way more than they attack you.

  14. Re:Bible Code? by lyml · · Score: 5, Interesting

    There are 4^3000 (about 1.5*10^1806) different 3000 letter works (if you only have 4 characters). The odds of finding your specific one in a 3 trillion collection of random letters is so small, you can't even imagine how small it is. (approx 1 in 2*10^1794)

    But let's try anyway. Imagine playing the universal lottery. You are supposed to pick one subatomic particle in the entire universe, and if you choose the correct one you get 1 nickle, the odds of winning is about 1 in 10^80, if you were to enter that lottery a billion trillion times a second (10^21) by the time all protons in the universe would have decayed the likelyhood that you would have won even once would be so small that you could not even imagine. Never the less.

    Now imagine playing that lottery one time for each billion trillion times times you look through a different set of random characters (with each set being 3 trillion characters). After having won that lottery, not once, but enough times to build a tower of your nickles 1000 times longer than the circumference of the entire universe the likelyhood of you having found a matching set to your 3000 character set would be so close to 0, that you still can not even imagine how small it is.

    So my guess would be that this virus dna didn't just appear by chance in the dna of humans.