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Wake Forest Researchers Swap Skin Grafts For Cell Spraying
TigerWolf2 writes with this excerpt from a Reuters story carried by Yahoo: "Inspired by a standard office inkjet printer, US researchers have rigged up a device that can spray skin cells directly onto burn victims, quickly protecting and healing their wounds as an alternative to skin grafts. ... Tests on mice showed the spray system, called bioprinting, could heal wounds quickly and safely, the researchers reported at the Translational Regenerative Medicine Forum."
... will bankrupt you.
Schroedinger's Brexit: The UK is both in and out of the EU at the same time!
Your fibroblasts cartridge is low. Would you like to connect to the HP Medical Printing website to order refills?
Looks like it cuts down on scarring as well, and it seems that grafting requires adding an additional injury from the donor section. Seems sensible not to do this.
In a sense, we've already outpaced science fiction. As recently as the 1990s, I enjoyed Larry Niven's Gil "the Arm" Hamilton stories (collected in Flatlander ), which foresaw a future so dependent on organ transplants for longevity that even the simplest of crimes like jaywalking would get the death penalty. With China in the news at the time for executing prisoners and harvesting organs, that kind of dystopian future seemed completely plausible. Niven didn't foresee alloplasty (gadgets instead of organs) becoming an alternative for centuries. But already stem cell research, nanotechnology and tissue printing shows that we are jumping directly to modifying the human body through purely artificial means.
Yeah, it would be a little disconcerting if during the meeting where they were trying to figure out an impartial way to decide who gets that job of burning the mice and the new lab tech jumps up furiously waving his hands saying "oh, me, me, choose me, pretty pretty please, choose me!" If that ever does happen I'd have a 2 part questionnaire for him to fill out. Question 1, do you like horribly violent movies like Saw or Hostel? (Y or N) Question 2, do you like musicals? (Y or N) if he says yes to both... serial killer. thank you venn diagrams.
As long as you're using printing technology to place cells over the wound, why not add pigments and voila! Instant tatoo!
I've abandoned my search for truth; now I'm just looking for some useful delusions.
My little sister actually had a summer internship with the Wake Forest Center for Regenerative Medicine. One of the things she would do is basically give puncture wounds to mice. After this experience, she apparently didn't want to be a researcher anymore.
The World Wide Web is dying. Soon, we shall have only the Internet.
All in the name of science!
Feeling bad about the rats is fine, it's normal.
But it's disingenuous to say they want to burn animals for a living. What they do for a living is try to build a device that could save many lives and help many more reduce their suffering. They are required to test them on animals before humans, it's part of the job. It's not a part of the job they like, but it's necessary so they do it. Could there be a sadistic few? Sure, but it's unlikely. There are far easier and better paid jobs that allow you to be sadistic to animals than research assistant at a lab. Rats are cheap, you can buy or even catch all you like. Getting your PhD to satisfy your sadism toward rats is taking things a bit far.
I would guess that most of them feel bad for the rats as well. But they can justify it with what they consider a higher purpose, reducing death and suffering. It might not be justifiable to you, but it is to them. It doesn't mean they like doing it.
And I respect your opinion if you don't think it's worth it. Just please recognize that both sides of the argument have merit, and don't assume those that think differently than you on the issue are amoral or hate animals, but probably only disagree with you over which is more important.
This sentence no verb.
Surgeon General's Warning: Prolonged exposure to this spray may result in one's skin gaining a metallic blue or red sheen. Yellowing of the eyes may occur.
It's already been pioneered, done and patented by Fiona Woods here in Australia http://en.wikipedia.org/wiki/Fiona_Wood. But we all know the USians only give a crap about their own patents, no-one else's. Just look at the shit-fight CSIRO had to go through to get money out of companies in the USA to honour their WiFi related patents.
She felt no compunction about stealing US inventions to help her "invention".
"r Wood turned to the emerging US-invented technology of cultured skin to save his life, working nights in a laboratory along with scientist Marie Stoner."
Sig Battery depleted. Reverting to safe mode.
There's a lot of work being done in this area right now- with good reason; there's tremendous potential, and the advance highlighted here is more of an incremental step in a rapidly maturing field than a breakthrough. As the parent notes, Dr. Fiona Wood pioneered a spray-on cell suspension over 15 years ago. She eventually founded a company (now called Avita Medical) which has commercialized this technology. In the last decade, it has been discovered that with minimal modification, an off-the-shelf inkjet printer can print living cells- this article is an example.
The story here from Wake Forest is apparently a successful test of using an inkjet to print directly on wounds using multiple cell types. The group reported these results at the Translational Regenerative Medicine Forum which took place the last few days. Who else happened to be at that forum? Avita Medical, where Dr. Wood still sits on the board.
"FDA staff reviewers expressed concern about the number of patients who were left out of the study because they died."
I once had a fascinating talk with a girl who worked at one of those labs and was given the job of killing the mice before they're analyzed.
Apparently in that lab it was the job they gave to all the newbies when they first arrived.
Yeah, while the premise is the same, implementations are not. The device being tested in the US is not the same as the delivery mechanism Woods uses, hence no invalidation for prior art.
Besides, what Woods should really be recognized for is not the spray-on delivery, but instead the advances in culturing techniques. This was the real breakthrough, IMO.
Of note, Woods got a lot of criticism for using her methods without it going through clinical trials. They're still not out of clinical trials, AFAIK...
"Trolls they were, but filled with the evil will of their master: a fell race..." -- J.R.R. Tolkien on Olog-hai
That's a great point. Humans are exactly like mice.
DRM: Terminator crops for your mind!
They are required to test them on animals before humans, it's part of the job. It's not a part of the job they like, but it's necessary so they do it.
At the risk of triggering Godwin's Law I feel I must point out that Animal Rights applied to a medical experiment context is what led the NAZIs, in about three steps, to medical experiments on concentration camp inmates.
Step 1: To avoid experiments on animals the experiments were performed on "mentally defective" humans - i.e. inmates of mental hospitals, initially those who were believed to be so brain-damaged or mentally deficient that they were less aware than animals.
Step 2: For politically convenient reasons, propaganda campaigns spread the idea that certain classes of people were subhuman - and by extension sub-animal: Jews, Gypsies, Communists, Anarchists, Labor Unionists, Gays, ...
Step 3: Large numbers of the classes in Step 2. were, for the convenience of the war effort, incarcerated in concentration/labor camps (where their assignment was mainly to be out of the way, and dying was a "good" way to accomplish this). At this point, being used in medical experiments was a way to complete that assignment and contribute to "humanity" in the process...
The Rise and Fall of the Third Reich is a very scary read. It shows that the NAZI movement started out with pretty much the full set of New Age Counterculture "virtues" (mysticism, animal rights, vegitarianism, body-beautiful health fads, back-to-nature, non-hierarchical consensus decision making, ...) and how these ideas coevolved into what now are considered such monsters that even looking at what they were like is considered anathema.
(Another example: Consensus decision-making evolves into totalitarianism in the presence of the normal fraction of psychopaths. First diversity and dissent paralyze group action. Then social pressures for conformity are developed to break the deadlock. These grow to be nearly irresistible. Then an individual or small group withholds consent except when the rest of the population does what they want. Finally the population follows their new "leaders" automatically, since that's what will finally happen anyhow.)
Bantam Dominique roosters crow a four-note song. Once you've heard it as "Happy BIRTHday" you can't NOT hear it that way