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Stem Cell Tourists Take Costa Rica Off the Agenda
An anonymous reader writes "Stem cell tourism is a booming and troubling industry, in which clinics in places like Mexico, China, and India offer rich tourists experimental stem-cell-based treatments, none of which have been approved by the FDA here in the US. (Check out some of these creepy sites that offer treatments for everything from autism to MS, and even the 'very common ailment called aging.') But in one positive development, Costa Rica just shut down its top stem cell clinic. Said the country's health minister, 'This isn't allowed in any serious country in the world.'"
In 1974, I released The Book Which Tells The Truth, which described my contact with the Elohim, the extra-terrestrials who created us scientifically in their laboratories, and who were mistaken for 'God' or 'gods' by our primitive ancestors, who were too ignorant to understand the truth. At the time, it was the public's enthusiasm for the 'UFO phenomenon' that made my books and the conferences I held around the world a success.
Nevertheless, when I explained that we would soon be able to do the same thing ourselves and live forever, thanks to cloning, many laughed. However, their laughter was tinged with the empty sound of those who have always been too shortsighted to see beyond their noses and foresee the fall of their own paradigms.
Which website will you pick to clone you? I think I'm going for the one that gave me some propaganda on a religion surrounding the Elohim. Sounds like they know what they're up to. Or maybe you've got advanced AIDS (one of the many treatable conditions which conveniently have no other cures) How does it work? Well, they just shoot you up with a bunch of stem cells. No, I'm serious:
Stem Cell Therapy, SCT, is a treatment that provides stem cells in the appropriate location to assist the body where it needs to heal and regenerate its existing cells.
Depending on the conditions, stem cells can be delivered through the blood stream or directly to the organ to treat. It isn’t understood yet how stem cell communicates with the body to determine and travel to sites of need but results have been observed showing stem cells located near the damage area and dividing there generating new differentiated healthy cells.
It's a process which many leading scientists suspect might be a miracle! And you know, if it doesn't work, you just didn't present the stem cells the right conditions and we just need you to pay for a trip back and more saline ... er therapy injections. Maybe you have a supressive person in your life who has been telling you that we are a scam and that's why the stem cell therapy didn't work? Anyone else reminded of Professor Farnsworth's trip to GeneWorks S.K.G. from Three Hundred Big Boys?
My work here is dung.
Human trials before approval on people who have the money to fund it... it might be incredibly dangerous and questionable ethically but these people who get these treatments pay themselves and take all the risks. Why not study them instead of stop them?
Don't tell that to someone with Gastroparesis. The FDA being influenced by large drug companies (especially the manufacturer of Reglan, the approved drug in the US) won't approve the the drug that is used in EVERY other industrialized country to treat this condition, Domperidone. A big part of that reason is lobbing. And the side effects of reglan is just plan scary.
Admit-tingly, the FDA does it job in general. But it is also a poster child of political influences and represents why government intervention in health care can be bad.
While many of the current stem cell clinics overseas do fall into the snake oil category one should not cast out the baby with the bathwater. If one understands the following probable guidelines, then one may be able to navigate the field.
1) Non-autologous (non-self) stem cells are likely to be extremely problematic for therapeutic purposes because there have been a number of reports showing that the immune system will eliminate those cells over time (without immune system suppression). If you view them as "organ transplants" from other individuals which require drug protocols to suppress Natural Killer Cells and other arms of the immune system with significant probabilities of rejection then therapies which involve non-self embryonic stem cells or non-self iPSC cells might be useful. But they are never going to be a "good" solution. (This means that the debate over "embryonic stem cells" which blocked a significant amount of progress in stem cell research in the U.S. over 8 years was useless "noise".)
2) Autologous (self) stem cell therapies *are* useful. One already effectively uses them in cases of storing sperm, eggs, blood and skin for future use. There have been common uses for decades such as for blood storage before a major surgery, growing skin grafts for burn victims breast reconstruction surgery, etc. Common heart bypass operations are another example of transplanting tissue from one region of the body to another. There has been a "Holy Grail" search to obtain embryonic or totipotent stem cells over the last decade due to the press/hype that they can "grow into any tissue". While we have the knowledge to do this for some tissues we do not have it for many more. Indeed one doesn't need totipotent cells for most therapies. Partially differentiated stem cells which are very close to the target tissue types will work as well, perhaps even better, than totipotent undifferentiated cells.
3) While injecting stem cells into the blood and hoping that they end up in the right place and will do the right thing works in some cases (e.g. bone marrow transplants) it is *not* likely to work for most applications of stem cells. Each type of therapy where stem cells may be used is going to have to be a precise tissue specific (heart, brain, lung, hair follicle, joint, tendon, muscle, blood vessel, skin, etc.) therapeutic protocol. That is why one is likely to see dozens of companies with specific expertise and not "one size fits all" solutions. There isn't going to be a "magic bullet" -- therapies are largely going to have to replicate, typically through cell culture in a laboratory, many of the natural processes which occur during fetal development in order for therapies to be effective.
4) There are on the order of 2300+ clinical trials in stem cells going on around the world (according to the NIH clinical trials database). Some of them are likely to be useless. But some of them might be quite useful.
5) There are companies in the U.S. that are doing autologous stem cell therapies with a fair amount of success. Three that I'm aware of are VetStem, Regenexx and BioHeart.
6) There has not been a widespread understanding yet within the stem cell R&D and therapy communities that stem cells *do* age. Simply, stem cells accumulate mutations in their genetic code with age which will cause them to function less well if sourced from elderly individuals compared with young individuals. [Everyone should have cryopreserved pools of stem cells when they were 10-15 years old.] So a stem cell therapy that might work very well in a young individual (say 20-30) may not work as well (or at all) in an older individual (say 60-70). There are methods that may be used to address this problem (disclaimer: I am the author of a pending patent on one of these methods) but they have yet to be put into practice by *any* stem cell clinic to the best of my knowledge.
So one can "dis" current stem cell therapies as being snake oil, often with some basis for the feelings, but you should