Slashdot Mirror


Doctors Reverse With Drugs Autism-Linked Fragile X Syndrome In Mice

An anonymous reader writes "New research by a team of Bangalore-based scientists has given hope to those with emotional problems caused by the inheritance of a fragile X chromosome. The researchers, for the first time in the world, mapped defective connections between nerve cells in the emotional hub of the brain of mice who had Fragile X Syndrome. The research has just been published in the online edition of the US-based Proceedings of the National Academy of Sciences." Besides the mapping of these nerves, though, "The NCBS team has shown that even the long-term ravages of the condition could be reversed with medication in mice." Fragile X syndrome is associated with autism, though the conditions do not map directly to each other.

17 of 63 comments (clear)

  1. Where There's a Will There's a Way by Saeed+al-Sahaf · · Score: 2, Informative

    There has to be some way to tie an Indian Call Center Joke into this...

    --
    "Who are in control, they are not in control of anything - they don't even control themselves!" - Glen Beck
  2. What? by XnavxeMiyyep · · Score: 5, Insightful

    Doctors Reverse With Drugs Autism-Linked Fragile X Syndrome

    What?

    --
    I put the 't' in electrical engineering.
    1. Re:What? by X0563511 · · Score: 2, Insightful

      That is a really -bad- headline.

      Removing two whole words would fix it too (words that aren't really required in the headline)
      Doctors Reverse Autism-Linked Fragile X Syndrome In Mice

      Really now... how they did it doesn't need to be in the headline.

      --
      For large sets, this will be our guide even unto death, for the LORD will work for each type of data it is applied to...
    2. Re:What? by Anonymous Coward · · Score: 2, Insightful

      They might be.

      If they had said "Doctors reverse Autism-linked Fragile-X syndrome with drugs" it seems that Fragile-X syndrome with drugs" is what is being reversed.

      It would have been more-easily-understood if the article was titled "Autism-Related Fragile-X Syndrome Reversed With Use Of Drug Treatment"

    3. Re:What? by spiffmastercow · · Score: 2, Insightful

      It's greatest as what you do can possible! Sense is perfect making!

    4. Re:What? by XCondE · · Score: 4, Funny

      Doctors Reverse With Drugs Autism-Linked Fragile X Syndrome

      What?

      Editors are sick of people not reading the summary so they're making the headline incomprehensible. Your move.

    5. Re:What? by lgw · · Score: 2, Insightful

      These days, headlines aren't for reading by humans, but by search engines. If "Autism drugs" is a trending search, it's a perfect headline - the words are even adjacent. It's the sad modern word of news.

      --
      Socialism: a lie told by totalitarians and believed by fools.
    6. Re:What? by Hognoxious · · Score: 2, Funny

      Animal experiments are scientific fraud.

      Not true. The Japanese have been doing experiments on whales for some time and the incontrovertible conclusion is that they taste very nice.

      --
      Confucius say, "Find worm in apple - bad. Find half a worm - worse."
  3. everyone from India? cure for slashdoters? by maxwells+daemon · · Score: 2, Interesting

    1. Aparna Suvrathan a,
          2. Charles A. Hoeffer b,
          3. Helen Wong b,
          4. Eric Klann b, and
          5. Sumantra Chattarji a,1

    - Author Affiliations
                a National Centre for Biological Sciences, Bangalore 560065, India; and
                b Center for Neural Science, New York University, New York, NY 10003

    These are lab findings in cells of knock out mice and indicate that the process may be still amenable to pharmaceuticals. All you Asperger's at /. keep this in mind!

  4. What Is Your Point? by Saeed+al-Sahaf · · Score: 3, Insightful

    In other words, at least 80% of individuals with autism need to find hope for a cure somewhere else.

    20% is an insignificant number? Not if your child has Autism. And suppose you had Cancer, would you pass on looking into a treatment because it "ONLY" had a 20% rate of potential improvement?

    Hoestly, what is your point?

    --
    "Who are in control, they are not in control of anything - they don't even control themselves!" - Glen Beck
    1. Re:What Is Your Point? by sjames · · Score: 3, Interesting

      Perhaps more to the point, if a cure works in the 20% of sufferers who's condition includes X and you are in that 20%, it's great news. It is unfortunate that it doesn't help the other 80%, but it';s not like that makes it a failure.

    2. Re:What Is Your Point? by nashv · · Score: 4, Insightful

      Actually, It is a rather good example. Autism is a set of symptoms that also have varying causes , Fragile X being one of them. Even the potential to fix one kind of cause is better than none.

      --
      Entia non sunt multiplicanda praeter necessitatem.
  5. Misleading headline. Fragile X != Autism by Trixter · · Score: 3, Informative

    The symptoms are similar but they are only tangentially related. The headline is incredibly misleading by suggesting a drug has been produced that can reverse autism, which is of course not true.

  6. Misleading headline, "mapped"=/="reversed" by AscianBound · · Score: 2, Interesting

    Both the /. and original news headline claim that scientists have found a way to "reverse" the fragile-x syndrome, but the study simply says that they have "mapped" the defective connections. That doesn't mean they know how to fix them yet...

  7. Related Slashdot post from June 27, 2007 by PatPending · · Score: 3, Informative
    --
    What one fool can do, another can. (Ancient Simian Proverb)
  8. Sweet. by DWMorse · · Score: 4, Interesting

    My oldest son has Fragile X and is diagnosed in the Autism spectrum. It's an incredibly impairing disability, and I'll be asking his doctor to keep on eye on the clinical trials.

    On a side note, as well voiced thus far, what headline is the hell up with what is there? For cryin' out loud.

    --
    There's a spot in User Info for World of Warcraft account names? Really?
  9. Doctor Reversed Nothing by DynaSoar · · Score: 4, Informative

    They supposedly mapped the connections involved.

    They previously determined what enzyme caused the damage and found something to inhibit it.

    They *assert* that they could possibly reverse the damage using this inhibiting enzyme. COULD.

    Inhibiting damage can prevent. You cannot inhibit damage already done. Inhibition and reversal are not the same. Nor are the two syndromes involved.

    Times of India ranks up there with Pravda when it comes to truthful accuracy, especially when it comes to home ground science. The "for the first time" gets read as though nobody had ever done this mapping before. It could as easily mean it was the first time they did it. It has been done before.

    The asserted reversal has also been done before. Not by them or by their New York friends, but at MIT.

    --
    "I may be synthetic, but I'm not stupid." -- Bishop 341-B