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Govt To Bomb Guam With Frozen Mice To Kill Snakes
rhettb writes "In a spectacularly creative effort to rid Guam of the brown tree snake, an invasive species which has ravaged local wildlife and angered local residents, the US Department of Agriculture is planning to 'bomb' the island's rainforests with dead frozen mice laced with acetaminophen. While it might not seem difficult to purge an island of snakes, the snake's habit of dwelling high in the rainforest canopy has so far thwarted efforts to rid the island of the pest. Eradicating the snake is a priority because it triggers more than 100 power outages a year at a cost of $1-4 million and has driven at least 6 local bird species to extinction."
You're right about the dangers of tylenol, it's bad especially combined with any other drug/chemical that strains your liver.
However, it's the only painkiller known safe for pregnant women. All the rest of 'em? Not so good!
--PM
It takes >4 grams/day to overdose. It's far from "ridiculously easy". You can have 8 extra-strength Tylenol in a day and still be okay. /pharmicist
Gone!
if you drink more 3 drinks a day, the overdose threshold can be as high as 6grams
since contrary to the popular belief, alcohol is actually protective in case of acetaminophen poisoning, since the P450 enzyme favour ethanol to acetaminophen so there is less N-acetyl-p-benzoquinone imine(the bad metabolite of Tylenol that fuck up your liver) produced, you can read more int he Merck manual
Jehovah be praised, Oracle was not selected
It's Guam (average temp 30C). Something the size of a mouse isn't going to stay frozen very long. The mice are attached to streamers so they get caught in the tree tops (where the snakes are) and get moved by air currents. They are testing it now, having already dropped 250 mice.
It's not physically addictive at all, and no more habit-forming than anything else that's fun.
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Single dose =/= maximum daily dose. Don't mix and match study types.
Acetaminophen metabolism follows first order kinetics and has a half life of 4-6 hours, depending on how healthy your liver is and how efficient your enzymes are. Taking one single 2.5g dose is probably enough to saturate your enzymes to the point that some damage will be done. However taking 4g divided in 4 doses of 1g every 6 hours will never get you over 2g total blood concentration since your body will be eliminating the drug.
Of course there's an entire other argument about chronic acetaminophen use depleting glutathione/methionine stores over time, but that's an even different story.
And then there's the other argument about chronic alcohol use, people who already have low glutathione stores and induced CYP2E1 cytochromes ready to zap that acetaminphen into NAPQI the minute it enters the liver - but why bore you with pharmacology when you can get your own doctorate?
Seven puppies were harmed during the making of this post.