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Central Dogma of Genetics May Not Be So Central
Amorymeltzer writes "RNA molecules aren't always faithful reproductions of the genetic instructions contained within DNA, a new study shows (abstract). The finding seems to violate a tenet of genetics so fundamental that scientists call it the central dogma: DNA letters encode information, and RNA is made in DNA's likeness. The RNA then serves as a template to build proteins. But a study of RNA in white blood cells from 27 different people shows that, on average, each person has nearly 4,000 genes in which the RNA copies contain misspellings not found in DNA."
Pretty much my reaction. DNA copying is a very high-fidelity but still imperfect process - why would RNA transcription and protein synthesis be any better?
The overall concept is still true.
=Smidge=