Slashdot Mirror


Oxford University Tests Universal Flu Vaccine

dbune writes "A universal flu vaccine has been tested by scientists at Oxford University. '... the vaccine targets proteins inside the flu virus that are common across all strains, instead of those that sit on the virus's external coat, which are liable to mutate. If used widely a universal flu vaccine could prevent pandemics, such as the swine flu outbreaks of recent years, and end the need for a seasonal flu jab.'"

36 of 218 comments (clear)

  1. Horatio says... by Anonymous Coward · · Score: 2, Funny

    This... *sunglasses* ...is nothing to sneeze at.

    YEAAAAAAAAAAH!

  2. side effects include... by outsider007 · · Score: 4, Funny

    counting toothpicks and knowing when to double down.

    --
    If you mod me down the terrorists will have won
  3. Worldwide death toll by proxima · · Score: 5, Insightful

    The worldwide death toll from the flu and its complications is in the hundreds of thousands. This is potentially more than just preventing an occasional annoying illness. It's more on the order of preventing all fatalities from traffic accidents.

    --
    "The universe seems neither benign nor hostile, merely indifferent." --Carl Sagan
    1. Re:Worldwide death toll by much+noisier · · Score: 3, Insightful

      I don't seek to undermine your important point, but I'd prefer to prevent all fatalities from traffic accidents. The people who die in car crashes probably have a better average quality of life and higher average remaining life expectancy than the typical person who dies of flu.

    2. Re:Worldwide death toll by antifoidulus · · Score: 2

      While true that recent flu strains have mostly killed those with weak immune systems(which actually does include very small children who probably would have survived if they hadn't caught the flu), in the past various flu strains have killed large numbers of otherwise healthy adults. It is these deaths that this vaccine can theoretically prevent, and none too soon. Statistically we are actually overdue for one of those strains to hit, which is part of what fuels the media frenzy every time a new strain of flu is discovered.

    3. Re:Worldwide death toll by sjames · · Score: 2

      If the crazy lines for the regular seasonal flu shot are any indicator, very few people are concerned about it.

    4. Re:Worldwide death toll by shermo · · Score: 2

      Statistically we are actually overdue for one of those strains to hit, which is part of what fuels the media frenzy every time a new strain of flu is discovered.

      Please, you give them too much credit.

      --
      Insanity: voting in the same two parties over and over again and expecting different results
    5. Re:Worldwide death toll by hedwards · · Score: 2

      Nope, because everybody knows that particular shot causes dyslexia.

    6. Re:Worldwide death toll by izomiac · · Score: 4, Informative

      Actually, when dealing with vaccines, quality of life is quantified and fairly objective. The term is "Quality-Adjusted Life Year. Life-years are measured, so a young child dying has more bearing than an elderly person, and the quality of each year is measured from zero (dead) to one (perfectly healthy). Technically, the range is a bit beyond that, as certain impairments are weighted as negative numbers, i.e. worse than death.

      Being subjective doesn't get you anywhere. If there are only enough healthcare dollars to save Frank xor Joe, then you need objective criteria for determining which you save. Frank doesn't get to die just because he isn't "enjoying life" enough. Discounting life based on perceived quality is exactly what we do. Take the terminal cancer patient for example. We could let them die in as little pain as possible when the usual treatment options fail, or we could perform CPR until every rib is broken and defibrillate until their chest is burnt leather, from the reasoning that, even in their pain-filled non-communicative state, we can't make judgments of their quality of life.

    7. Re:Worldwide death toll by jamesh · · Score: 2

      Tough call which is the greater good, preventing all automobile fatalities, or preventing all influenza deaths.

      Not that tough really. In the absence of a perfect and universal flu vaccine you simply can't prevent all influenza deaths. I can come up with several solutions to prevent all automobile fatalities, but nobody would like them, they wouldn't get implemented (or obeyed), and people would still die on the roads.

      If you do the cost/benefit analysis on it then the answer is pretty easy. I bet the billions of dollars being spent on flu vaccine could save thousands or millions of lives (and all the other associated costs of being sick) over a 20 year period, but those same billions of dollars wouldn't make a significant dent in automobile fatalities over the same 20 year period.

    8. Re:Worldwide death toll by Mr0bvious · · Score: 2

      Good points, and I agree.

      My issue still persists in that you still need to be subjective in determining the objective criteria - I'm not claiming there is a better way though.

      The parent to which I replied did not seem to be referring to the same objective measures you raise.

      --
      Never happened. True story.
    9. Re:Worldwide death toll by quenda · · Score: 2

      Here in Finland many children have got narcolepsy (for life!) as a "side effect" from the H1N1 vaccine. .

      No they have not. Vaccinations were suspended on fear of a possible link. But no evidence has been found. Just another false alarm that get far more media attention than the subsequent negative findings.
      A classic example of hysterical anti-vaccine, anti-science rumour-mongering here.

    10. Re:Worldwide death toll by sznupi · · Score: 2

      living a healthy lifestyle is the best protection

      Living in a place with lots of vaccinated people, hence very low overall infectivity / no epidemics?

      --
      One that hath name thou can not otter
    11. Re:Worldwide death toll by AK+Marc · · Score: 2

      It's called vasectomy or tubal ligation. It won't cure it in the host, but it prevents the spread, if administered young enough.

    12. Re:Worldwide death toll by Abstrackt · · Score: 5, Funny

      The people who die in car crashes probably have a better average quality of life and higher average remaining life expectancy than the typical person who dies of flu.

      No, I'm quite sure they're still both dead.

      --
      They say a little knowledge is a dangerous thing, but it's not one half so bad as a lot of ignorance. - Terry Pratchett
    13. Re:Worldwide death toll by TapeCutter · · Score: 2

      Mercury is a wonder drug, imbibing a single glassfull of the silvery elixir will cure any malady, including autisim.

      --
      And did you exchange a walk on part in the war for a lead role in a cage? - Pink Floyd.
    14. Re:Worldwide death toll by mdielmann · · Score: 2

      Worldwide flu death is estimated at between 250k and 500k per year. Car accident fatalities are estimated at 1.2 million per year. So the difference is a factor between 2 and 5 (not terribly high), and in the opposite direction from what you supposed.

      --
      Sure I'm paranoid, but am I paranoid enough?
  4. Re:1 question by Securityemo · · Score: 3, Funny

    Does it ever! Not only does it cause autism, it will cause all children under 16 years of age to mutate into cannibalistic 30-feet-tall ivory-skinned humanoids with six fingers and large feathery wings! Buy a batch now - our special Rapture(TM) offering lasts only until the breaking of the Seventh Seal or the destruction of our facilities and board members by fire and brimstone, whichever comes first!

    --
    Emotions! In your brain!
  5. Zombies by Goboxer · · Score: 5, Funny

    Isn't this how most modern zombie movies start?

    1. Re:Zombies by Dynamoo · · Score: 2

      The novel "Feed" by "Mira Grant" (a pseudonym) does indeed use something similar as a premise. A cure for the common cold and a cure for cancer have unfortunately side effects when combined.. nobody gets a cold or cancer any more, but they do turn into zombies when they die.

      --
      Never email donotemail@WeAreSpammers.com
  6. Re:Hmm.. by uigrad_2000 · · Score: 3, Interesting

    In her trial, Gilbert vaccinated 11 healthy volunteers and then infected them, along with 11 non-vaccinated volunteers, with the Wisconsin strain of the H3N2 influenza A virus, which was first isolated in 2005.

    "Fewer of the people who were vaccinated got flu than the people who weren't vaccinated," said Gilbert.

    Can you guess where I'm going with this? ..... Small.... sample.... size....

    Here's a hint: Yesterday, the NFC won the coin toss for the super bowl. That makes 14 years in a row that the NFC has won the coin toss. Does that prove that the coin toss is not random?

    --
    Free unix account: freeshell.org
  7. Of course there's one question by Petersko · · Score: 4, Funny

    Will one shot be sufficient to turn me completely autistic? Or do I need booster shots? I'd better consult the best source possible: Jenny McCarthy. I hear she's, like, awesome with autism.

  8. Re:Hmm.. by Damarkus13 · · Score: 5, Informative
    Way to cherry pick a quote. Here's the rest of it.

    "We did get an indication that the vaccine was protecting people, not only from the numbers of people who got flu but also from looking at their T-cells before we gave them flu. The people we vaccinated had T-cells that were more activated. The people we hadn't vaccinated had T-cells as well but they were in a resting state so they would probably have taken longer to do anything. The volunteers we vaccinated had T-cells that were activated, primed and ready to kill. There were more T-cells in people we vaccinated and they were more activated."

    This test appears to be about safety and confirming some sort of t-cell response, not effectiveness.

  9. Re:Anybody with knowledge in the field.. by artor3 · · Score: 3, Informative

    Well, I am by no means an expert on this stuff, but I think the idea is to make what's called a protein subunit vaccine. They take a key protein from the disease and implant it in some other virus. Your body attacks that virus and develops an immune response to the targeted protein. It's being used in experimental vaccines for AIDS and, apparently, Influenza. However, I don't know if there are any cases of it being done successfully on a large scale.

    If it works out, it would be fantastic - effective vaccination for two of the worlds biggest killers, which could potentially save millions of lives per year. However, first they need to get it working, and then they need to find a way to make it cheap enough to use in the third world, since that's where most of the deaths occur. It might help that a universal flu vaccine would be very popular in the first world, and could provide them with the money to ramp production.

  10. Re:This line in TFA confused me by mentil · · Score: 2

    Most vaccines present weakened viruses so that the body's immune system will know how to fight it. Once it's gained a +5 Antibody of Influenza-Slaying, it can defeat the higher-level flu viruses.
    This treatment is a substance that boosts T-cell count, so it doesn't only work as a vaccine.

    --
    Corruption is convincing someone that the selfless ideal is the same as their selfish ideal.
  11. Re:What is the point? by Dunbal · · Score: 2

    On the contrary, they will produce this vaccine. Especially since it does nothing to address animal reservoirs of influenza, so they get to sell vaccines to everyone in the world and since influenza is not eradicated by it - for a long time.

    --
    Seven puppies were harmed during the making of this post.
  12. Re:Anybody with knowledge in the field.. by Imrik · · Score: 3, Insightful

    Oddly enough, reducing mortality rates goes a long ways towards lowering population growth. People who expect their children to survive will have fewer of them and invest more resources into the ones they have.

  13. Re:This line in TFA confused me by Imrik · · Score: 2

    It's badly worded, it's saying that they were deliberately infected after being vaccinated not that they were already infected when they were vaccinated.

  14. Re:1 question by Brett+Buck · · Score: 5, Interesting

    The desperate hangers-on to the entirely discredited "vaccine" = "autism" theory recall another bizarre and desperate group I saw on a TV show the other day.

          They were having a panel of "crop circle experts" discuss all the mysterious alien influences and methodology underlying a nearby crop circle flap. After a few hours, some people stand up at the back, and state that *they* made the crop circles. They also showed a video-tape of themselves making the crop circles. The crop circle experts claimed - in all seriousness - that the aliens FAKED the tape, and then brainwashed the people into claiming they were responsible.

         

  15. "Insightful," my ass. by westlake · · Score: 5, Insightful

    We all know that the drug manufacturers wont produce this vaccine. Currently they have a constant revenue stream with a new vaccine needed seasonly. Greed is better than a cure. It's a false hope.

    Why does this nonsense always get a mod-up?

    Look around you.

    See anyone dying of Smallpox? Measles? Polio? Diphtheria? Tetanus? Has your daughter received the HPV - Cervical Cancer vaccine?

    There is big money to made in treating cancer.

    Why do you suppose that this vaccine wasn't suppressed?

    The answer is that the cure brings with it a new level of understanding. It exposes opportunites that had never before been seiously considered.

    When most men and women were in failing health along about age 45 or so, it didn't make much sense to put real money into studying arthritis, cancer, glaucoma, senile dementias, and so on.

  16. Re:Anybody with knowledge in the field.. by hedwards · · Score: 3, Insightful

    I was going to post that. Another thing which is really great for decreasing population growth is ensuring that parents don't have to be supported by their children in old age. That reduces the pressure to produce many children and as a result parents tend to have fewer children or none at all of their own choosing.

  17. Re:Would this work for the Common Cold? by hedwards · · Score: 3, Insightful

    The common cold isn't caused by one virus, there's many different ones which are responsible. So in other words you could probably create an immunization to cover most of it, but you'd be stuck developing a vaccine like this for each of them ones.

  18. Re:this may sound cold-hearted... by BradleyUffner · · Score: 2

    "If used widely a universal flu vaccine could prevent pandemics, such as the swine flu outbreaks of recent years, and end the need for a seasonal flu jab."

    I didn't read the journal article, but it sounds as though somebody's advocating distributing this vaccine every year during flu season (prophylactically).

    If a vaccine is successful, shouldn't we hold on to it and only distribute it during potential emergencies such as the emergence of H1N1? I would think the last thing we should be doing is breeding super vaccine-resistant flu viruses by over-medicating. It seems like whenever a new treatment is discovered, we deploy it immediately. Suppose if we deployed this new flu vaccine, in the best case scenario, we could save a hundred thousand lives per year, every year, for a decade or two, (and there's probably a lot of profit to be made in the process). But if we distribute the vaccine sparingly, perhaps it would remain effective for longer, and we could save tens of millions of lives when the next pandemic hits.
    It's an interesting mathematical dilemma, but I've never seen anybody bring this up. What is the best solution?
    (I've had this question for a while. It seems like a great question for the slashdot crowd.)

    Vaccines are only effective BEFORE someone is infected, and even then they need time to work. By the time it's a wide spread emergency or pandemic it's too late to immunize.

  19. Re:Kill most all viruses, invulnerable ones yet li by mibe · · Score: 2

    Just like the polio vaccine created super polio, and the smallpox vaccine created monstro-pox, which subsequently ravaged the greater Eurasian continent before - hey wait a minute! That's what I get for using Wikopedia instead of the real thing!

  20. Re:Hmm.. by nospam007 · · Score: 4, Insightful

    "The seasonal flu is not a danger in countries with basic hygiene and sufficient access to medical facilities."

    Since some years over 49000 people died of the flu in the US (_with_ umpteen millions vaccinated), does that mean it's not a country with basic hygiene and sufficient access to medical facilities?

  21. Re:Hmm.. by Ihmhi · · Score: 2

    Don't buy into the BIG CRACKA chiropractic scam!

    "Discloser:" I am an average adult male with over 15 years of common sense. A true bullshit-detecting professional.

    Facts: Chiropracty causes your wallet to become lighter and nothing much else, Penn and Teller have proven it. These brave men have been vilified by the BIG CRACKA controlled BIG INTERNETS.

    All a person needs for good health and long life are:
    1) Proper nutrition.
    2) Plenty of exercise.
    3) Regular critical thinking exercises.
    4) Avoid BIG CRACKA controlled "doctors"!

    Regular critical thinking exercises offer plenty of benefits:
    1) Improved B.S. detection.
    2) Increased money in your wallet.
    3) Help with putting these scam artists out of business.
    4) Increased brain function.

    In short: DO NOT VISIT CHIROPRACTORS!