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Gut Bacteria Exert Mind Control

sciencehabit writes "Hundreds of species of bacteria call the human gut their home. This gut 'microbiome' influences our physiology and health in ways that scientists are only beginning to understand. Now, a new study suggests that gut bacteria can even mess with the mind, altering brain chemistry and changing mood and behavior (abstract)."

42 of 221 comments (clear)

  1. Already knew that... by SpasticWeasel · · Score: 3, Funny
    --
    No sooner do I get over one, then you put a better one right next to me. Bastards.
    1. Re:Already knew that... by m50d · · Score: 2
      --
      I am trolling
  2. Are you pondering what I'm pondering? by Anonymous Coward · · Score: 2, Funny

    In this case, the side effects appeared to be beneficial. Mice whose diets were supplemented with L. rhamnosus for 6 weeks exhibited fewer signs of stress and anxiety in standard lab tests, Cryan and colleagues report online today in the Proceedings of the National Academy of Sciences.

    ...

    "This was really exciting because it tells us the animals are more chilled out and don't mount the same stress response," Cryan says.

    Or maybe the mice just felt good after having taken a really satisfying dump.

    Brain: Are you pondering what I'm pondering?
    Pinky: Uh, I think so, Brain, but burlap chafes me so. NARF!

  3. Unnerving by Verdatum · · Score: 3, Funny

    I liked the bit where they cut the vagus nerve. Before I got to that point in TFA, I was thinking "Well sure, rats fed lactobacillus will have lower stress levels! Life isn't as stressful when you poop good!"

    1. Re:Unnerving by causality · · Score: 2

      Yeah, I considered that bit too. But I still say it's a decent start at trying to sort out causality.

      Says you.

      --
      It is a miracle that curiosity survives formal education. - Einstein
    2. Re:Unnerving by Will.Woodhull · · Score: 2

      Causality is a useless attempt at simplification in any reasonably healthy ecosystem. Including the internal ecosystem of any mammal that is not actually in the last stages of dying.

      This stuff is better handled by thinking of it as Skinner type black boxes. Give the gut a stimulus, look for a consistent response. You can do lot of good science at that level. But try to get any more mechanistic than that and there are too many possible alternative pathways and, at this point, by far too little established knowledge to make judgments about the likelihood of any given causal path.

      Remember, this post is being generated by a sentient being whose thoughts are influenced by the billions of microbes that are happily living in his gut.

      --
      Will
    3. Re:Unnerving by Will.Woodhull · · Score: 2

      Oh.

      What's funny is that I didn't hear the "Woosh". Usually I hear the "Whoosh" just after I push the Submit button, so I get the full benefit of self-humiliation from the earliest possible moment.

      --
      Will
  4. Impossible! by fuzzyfuzzyfungus · · Score: 2

    The assumption that I posses a mysterious "free will" that is somehow divorced from cause and effect(except in that it causes me to act) is simply too convenient to abandon!

    1. Re:Impossible! by Hatta · · Score: 2

      Free will is just as incompatible with a random universe as it is with a deterministic universe. Random events are statistically deterministic. We know that quantum events are truly random, and not affected by hidden variables (such as "will"), due to Bell's theorem. Free will is simply incompatible with what we know about physics.

      --
      Give me Classic Slashdot or give me death!
    2. Re:Impossible! by hawkfish · · Score: 2

      Free will is just as incompatible with a random universe as it is with a deterministic universe. Random events are statistically deterministic. We know that quantum events are truly random, and not affected by hidden variables (such as "will"), due to Bell's theorem. Free will is simply incompatible with what we know about physics.

      That's not what Bell's theorem says. It say that quantum physics must necessarily violate either the principle of locality or counterfactual definiteness. Free will could violate locality if it was the result of agents external to the universe. Conversely, free will could violate counterfactual definiteness if the universe was being made up as we go along. The latter seems not only compatible with free will, but a necessary consequence of it.

      --
      You will not drink with us, but you would taste our steel? - Walter Matthau, The Pirates
  5. chemicals by Haven · · Score: 4, Interesting

    There is far more serotonin present in your gut than in your skull.

  6. I wasn't going to post anything by SmurfButcher+Bob · · Score: 3, Funny

    but I just had this gut feeling that something bad would happen if I didn't.

    --

    help me i've cloned myself and can't remember which one I am

  7. Re:Overlords oblig! by tibit · · Score: 2

    No, yes or no, no?

    --
    A successful API design takes a mixture of software design and pedagogy.
  8. Re:Well by hrvatska · · Score: 4, Insightful

    I think these are more like innerlords.

  9. So the spleen is the seat of emotions after all? by Jaryn · · Score: 2

    So the spleen is the seat of emotions after all?

    http://altmedicine.about.com/cs/anxietydepression/a/EmotionsTCM.htm

    Then forget the Zoloft, gimme my strawberry-banana yogursicle.

  10. Re:Overlords oblig! by Acapulco · · Score: 2

    No, no. No?

    --
    Slashdot. Unreadable news to annoy nerds. - wonkey_monkey
  11. Was this unexpected? by Obfuscant · · Score: 2
    This was unexpected?

    There are millions of people every day dependent upon manufactured medications to maintain mental function, and millions more who are taking medication because someone else thinks they need mental function adjustement. Those medications are, for the most part, administered orally.

    What, does it surprise anyone that a bacterium producing a mind altering compound in the gut would have that compound absorbed and transported via the bloodstream, when we depend on exactly that transport method for manufactured drugs?

    1. Re:Was this unexpected? by Muros · · Score: 2

      I don't think it's particularly surprising either. However, I would be interested in seeing research into what common gut flora & fauna produce what effects, and how particular dietary elements influence population sizes of those specific organisms.

  12. Another sensationalistic headline by jklovanc · · Score: 2

    When did /. become a tabloid? This has nothing to do with "mind control". Control implies intent and I am pretty sure that a bacteria in the digestive tract have no intent to "explore narrow walkways".

    The bacteria makes the stomach feel better and the vagus nerve transmits this feeling to the brain thereby reducing stress. There is a funny thing about stress. The response to stress is not linear it is exponential. If someone under no stress has a little stress added they can deal with it. A person under a lot of stress has the same amount add it can push them over the edge. A good example of this is losing keys. If you are about to leave the house to go for a walk and cant find you keys it is not a problem; most people just delay the walk until they find their keys. Now lose your keys when you are trying to get to the airport with 4 excited children. That small stressor can drive you insane. Same stressor, different initial stress level, different response. So the stomach feeling good lowers stress levels and allows the rodent to handle added stress better. Animals under stress avoid stress.

    Do bacteria in the digestive tract affect animals? Yes, by making them feel better and having less stress. Do bacteria in the digestive tract control the mind? No, that do not make animals do things they do not want to do.

    1. Re:Another sensationalistic headline by Livius · · Score: 2

      It's an issue of adaptation, not intent. Lots of parasites alter their hosts' behaviour, which is mind control by definition. The control may be crude but that's not the point.

  13. Neuropeptide Y or S or CCK by JonySuede · · Score: 2

    This bacteria must interfere with possibly a combination of the Neuropeptides Y, S and CCK pathways. The CCK-4 neuropeptide is pretty nasty, it cause instant panic attack reliably at 75ug.

    --
    Jehovah be praised, Oracle was not selected
  14. vastly outnumbered by our bacterial overlords by nido · · Score: 2

    There are more bacteria in our intestines than cells in the body, by some estimates. I was disappointed by this comment:

    The findings "open up very exciting speculation" about using probiotics to treat mood disorders in people, says Emeran Mayer, a gastroenterologist at the University of California, Los Angeles.

    The types of bacteria in one's intestines are highly dependent on the substrates available. A person who eats a vegetable-rich diet every day - especially grated carrots with salt and vinegar or jerusalem artichokes (rich source of the prebiotic carbohydrate inulin) - will have a totally different types of bacteria in their intestines than those who survive on Big Macs, Fries and carbonated beverages, with or without the probiotic supplement.

      It's sorta like... growing a garden. If your plants don't have nutrients, they won't grow very big... But add the right kind of fertilizer, and they'll really take off.

    --
    Learn the rules so you know how to break them properly.
    www.teslabox.com
    1. Re:vastly outnumbered by our bacterial overlords by thunderclap · · Score: 3, Funny

      So you are saying that Vegans are crazy because they don't eat meat and those microbes exert a greater influence because of it?

    2. Re:vastly outnumbered by our bacterial overlords by WillKemp · · Score: 2

      Yep, as the old saying goes, you are what you eat.

      But something else that has a major influence on your gut flora is antibiotics - which quacks hand out like lollies ("sweets"/"candies", for the linguistically challenged). So just changing your diet may not be enough, because the necessary bacteria may simply not be there any more.

      There have been reports (in New Scientist among other sources) of the success of what are euphemistically called "fecal transplants". Getting the right microbes into your gut - and in particular, getting them past the very unfriendly environment of your stomach - is challenging.

    3. Re:vastly outnumbered by our bacterial overlords by SecurityTheatre · · Score: 2

      What's a "food-related craziness" and how does one define the difference between other types of crazy?

      And it's odd you say that, many of the vegans I've known have been quite odd people. I always attributed the vegan choice to the oddities, rather than the other way around...

      I do know that vegans have to be insanely careful about what they eat to be healthy and I've known a few athletes who tried to go vegan and their body just couldn't handle it, responding like they were short on important nutrients, their energy, stamina and recovery speed were notably diminished.

      I'm going to say what I always say. Doing something "hardcore" is probably bad for you. Why not have a balanced diet? We are evolved as omnivores and it's challenging to try to hotwire that.

    4. Re:vastly outnumbered by our bacterial overlords by mysidia · · Score: 2

      but perhaps they are weird because they are vegans!

      Are you sure the microbes weren't controlling their mind and causing them to be and become vegans?

      Which came first... the veganism or the bacteria that likes their host to be vegan?

  15. Interesting. by mevets · · Score: 2

    I've always thought of Big Macs as being quite similar to fertilizer. Do you think they have some benefit?

    1. Re:Interesting. by nido · · Score: 2

      depends on what kind of bacteria you want to feed. If you want to cultivate bacteria that produce "signs of stress and anxiety", big macs are exactly what you're looking for. :)

      --
      Learn the rules so you know how to break them properly.
      www.teslabox.com
    2. Re:Interesting. by Belial6 · · Score: 3, Insightful

      I know it's fun to make fun of the big bad corporation, but really. Gassy and ADD? If you are getting gassy from McDonald's food, it isn't because the food is bad. It is because your digestive system is broken. And ADD? That is just pulling things out of thin air.

    3. Re:Interesting. by ChromeAeonium · · Score: 2

      Artificial Fertilizers tend to distort the natural soil microbiology

      Not on the land they're not applied. Consider what the ability to produce more food on less land does for the overall environment. People act like artificial fertilizers are this big horrible thing, but they're actually a pretty decent trade-off.

      cause stunted root development

      Uh, yeah, plants grown in high nutrient environments grow less roots. Those in need of more nutrients grow longer roots to seek out more nutrition, those already with enough don't.

      balance and moderation is the key.

      The same holds true in inorganic and organic (and by that I mean the real definition of organic, not the new magical one) fertilizers.

    4. Re:Interesting. by Belial6 · · Score: 2

      You don't seem to understand what the word natural means.

    5. Re:Interesting. by Kreigaffe · · Score: 2

      No, the human body has evolved to eat whatever kind of food it can fit into its mouth.

      We're dogs. We're pigs. Your stomach upset is caused not because of genetics, but because your body is accustomed to a high-quality diet. It is no longer able to digest garbage.

      That is, unless you think you could find a day-old carcass laying around, cut it up, warm it over a fire and eat the half-cooked results without shitting out your lungs.

      Your belief that fast food contains no real food is a bit misguided, anyway. Do you believe EVERYTHING you read? Do you have power crystals laying around? Christ..

      --
      ... still waiting for this free-as-in-beer free beer I keep hearing about. :|
    6. Re:Interesting. by maxwell+demon · · Score: 2

      There's virtually no natural food in fast food

      There's virtually no natural food in traditional food, either. Almost all meat is cooked, roasted, fried or otherwise treated. The same is true for a lot of plants. Most plants and animals we eat are not in their natural form anyway, but modified by centuries-long bioengineering (called breeding).

      --
      The Tao of math: The numbers you can count are not the real numbers.
  16. Charles Dickens nailed it by FranTaylor · · Score: 4, Insightful

    "You don't believe in me," observed the Ghost.

    "I don't." said Scrooge.

    "What evidence would you have of my reality, beyond that of your senses?"

    "I don't know," said Scrooge.

    "Why do you doubt your senses?"

    "Because," said Scrooge, "a little thing affects them. A slight disorder of the stomach makes them cheats. You may be an undigested bit of beef, a blot of mustard, a crumb of cheese, a fragment of an underdone potato. There's more of gravy than of grave about you, whatever you are!"

  17. My Gut Reaction by ichthus · · Score: 3, Funny

    My gut tells me this story is complete nonsense. Yep, nothing to see here. Move along.

    --
    sig: sauer
  18. Re:This is nothing new by MaWeiTao · · Score: 2

    It's true that they've made some very insightful connections long ago. But so have the Europeans. It's just that it's the current fad to be into Chinese medicine. And from experience I've found a lot of it to be flat out wrong or at least misguided.

    I mean, if they had it all figured out China should have the longest life expectancy on earth, and they don't. Although, I'm not discounting Chinese doctors either, because much of what they do is indeed effective. But I wouldn't be surprised if more Americans got acupuncture than Chinese did. The fact is that when someone in Asia gets sick, they go to a regular doctor like us and get prescribed the same kinds of medicine we get.

    If anything, they medicate even more heavily than American doctors do. Get a cold here and the doctor tells you to take tylenol. In Asia you get a cold and they'll give you several different pills; aggressive fever reducers, sleeping pills, a couple of others for various symptoms and antibiotics for good measure

  19. Re:Well by Sulphur · · Score: 4, Funny

    I think these are more like innerlords.

    This too shall pass away.

    --

    Never let a computer or a cat know that you are in a hurry.

  20. Re:Overlords oblig! by treeves · · Score: 2

    Yeah, yeah. Whatever.

    --
    ...the future crusty old bastards are already drinking the Kool-Aid.
  21. Re:This is nothing new by ChromeAeonium · · Score: 2

    But what would they know compared to our few hundred years of research in Western medicine?

    Not enough to know that there's no such thing as chi/ki/prana apparently. As for this mind-gut connection, enlighten me, does it say anything specific or relevant to anything related to gut flora? Or is it just that eating good food makes you feel better (which falls firmly into the no shit category), mixed with a heaping helping of nonsense about 'yin foods' and 'yang foods'? I'm not making that up; TCM practitioners actually believe that some foods have magical heating (yang) or cooling (yin) abilities, and that eating too much of the one or the other will screw you up. And before you say 'well yeah, cucumber is cool and pepper is hot' take note that the lychee (one of the best foods most westerners have never heard of, tastes kinda like a grape, but grows on a tree and has a hard red skin) is one of the yangiest foods (cherries and pineapples are also yang). Could there be a scientific basis behind it? Dunno, maybe a thousand years of anecdotes amounts to something. But given the complete lack of actual science to back those points, and the plethora of just plain stupid things TCM guys also believe in (ever seen the dried lizard/worm/wood/who-knows-what-else infusions they make?), I sure as hell don't buy it until someone gives me more than the Chinese equivalent of the four humors (which, I have no doubt, if some magical foreigners had invented, these morons would be buying that too, but since it's European then it is just dumb).

  22. Re:On a completely unrelated note by treeves · · Score: 2

    Funny you should mention those specifically. I remember hearing a story about Toxoplasma causing people to behave in higher-risk ways, like driving faster.
    As for how that relates to how it makes mice (that may be harboring Toxoplasma) attracted to the urine of cats that will want to eat said mice (to aid its spread), I cannot imagine.

    --
    ...the future crusty old bastards are already drinking the Kool-Aid.
  23. That Jives with my Experience with Crohn's by plurgid · · Score: 2

    This was very much my experience with Crohn's disease.
    Well actually, it turned out not to be Crohn's, but a rare type of cancer called an gastronoma, but that's kind of an aside.

    What I found is that the mind-gut connection is a two way street.
    You know how your gut gets all twisted and you get the shits, nausea, etc when you are *really* stressed out?
    Well if that shit happens (no pun intended) on the regular ... your mind starts to react as if stress were the cause.

    I had almost no stress (other than the health stuff, which we didn't know was a big deal until the end -- just in time, actually). I just thought I had Crohn's disease, which I had medicine for and wasn't particularly stressed over, but my gut was twisting and wretching day in and day out, and I had this ill-defined sense of dread and anxiety. Couldn't tell you why, but I was definitely stressed about ... something ...

    In any case, I believe it. Your moods, are very much intimately intertwined with how your digestive tract. More than people usually realize I think.

  24. Re:This is nothing new by WillKemp · · Score: 2

    Indeed. Marvel in awe at their [China's] advanced political system.

    Does it really make much difference? In Australia, we get a choice of two parties who are virtually identical. We can vote, but it won't make any difference to anything much. It's the same in the UK and, as far as i can tell, the same in the US.

    As far as differences between countries go, Australia and the UK don't have capital punishment, China and the US do. Australia and the UK have good social security and universally available health systems, China and the US don't. The Chinese government censors the internet a lot, Australia and the UK censor it a bit, and in the US they use litigation to censor it. The US has the highest incarceration rate in the world at 743 per 100,000, UK: 150, Australia 133, China: 120.

    And China's doing considerably better economically than either of the UK or the US!