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Researcher Builds Life-Like Cells Made of Metal

Sven-Erik writes "Could living things that evolved from metals be clunking about somewhere in the universe? In a lab in Glasgow, UK, one man is intent on proving that metal-based life is possible. He has managed to build cell-like bubbles from giant metal-containing molecules and has given them some life-like properties. He now hopes to induce them to evolve into fully inorganic self-replicating entities. 'I am 100 per cent positive that we can get evolution to work outside organic biology,' says Lee Cronin at the University of Glasgow. His building blocks are large 'polyoxometalates' made of a range of metal atoms — most recently tungsten — linked to oxygen and phosphorus. By simply mixing them in solution, he can get them to self-assemble into cell-like spheres."

14 of 259 comments (clear)

  1. Dear researchers: by mdenham · · Score: 5, Funny

    Please make sure that these are vulnerable to projectile weaponry. The last time we had to deal with life forms of this sort, it was a real pain.

    Signed,
    Col. Jack O'Neill

  2. Shameful hype by Linzer · · Score: 5, Insightful

    This has to be the most overhyped, buzzword-ridden science story I've read in months. As a researcher, I hate to see whatever credibility we have spent on things like this.

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    Gravitation is a theory, not a fact.
  3. In a TED talk on this, he said 2 years by gilleain · · Score: 4, Informative

    When asked in a talk on this, he claimed that they would have fully replicating matter (IE : 'living' inorganic matter) in 2 years. The host who asked the question sounded startled when he said "That would be, er, something amazing, yes" - in other words "Yeah, right!".

    On the other hand, the lab's publication list is quite impressive, and full of cool looking polygonal structures : http://www.chem.gla.ac.uk/cronin/publications.php

  4. They don't do self-replication by satuon · · Score: 4, Insightful

    Without self-replication I wouldn't call them life, evolution can't work without self-replication of some sort.

    1. Re:They don't do self-replication by Your.Master · · Score: 4, Insightful

      Evolution requires replication, not necessarily self-replication. An earlier poster mentioned viruses, which are an example of a thing, living or not (I'd say not), that evolves without replicating itself.

      Broadly speaking, "human men" and "human women" are each not self-replicating, but the system of "human men and human women" is self replicating. Still, you can speak of features that evolved in women distinctly from men, such as prominent breasts, even though human women in isolation do not self-replicate. So as a gedankenexperiment, imagine you have an imperfect cloning machine and a world of only men (the clones pop out full-grown). This single-sex could use it to replicate indefinitely and evolve. And if those men maintain, repair, and build new cloning machines, then you have a species which doesn't self-replicate by itself, but the species-cloning-machine system is self-replicating, much as the man-woman system is self-replicating. Now you can imagine that no new cloning machines are ever made but the one was built to last a hundred million years. Now there is *no* system that's self-replicating but the men still replicate, with the help of the cloning machine, and therefore still evolve.

      I don't see why evolution would be a requirement of life anyway. Evolution is merely an inescapable consequence of anything which replicates iteratively and imperfectly, whether or not it is life.

      I do know some traditional definitions of life require self-replication, at the species level.

  5. Cells, riight by qbast · · Score: 3, Insightful

    So he made some 'bubbles' that don't dissolve and can mimic some simplest properties of a cell like porous membrane. Without self-replication it is not cell or anything resembling life and without some way to change and pass those changes onto next generation there can be no evolution. In related news: I took a cardboard box and painted 'screen' and 'keyboard' on it. It totally proves that laptop can be made from cardboard. Of course it does not work, but this is just a little detail that can be worked out later.

    1. Re:Cells, riight by Sockatume · · Score: 4, Informative

      Given that reproducing the properties of the membrane is one of the biggest outstanding problems in the creation of artificial cells, it seems pretty obvious that this is a step forward.

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      No kidding!!! What do you say at this point?
    2. Re:Cells, riight by silentcoder · · Score: 4, Insightful

      > Without self-replication it is not cell or anything resembling life

      Nobody ever said self replication has to work the same way it does for us. The article does say he found ways for the cells to use other cells as templates for modification and indeed replication.
      It's an interesting approach to replication - as it changes one existing cell into a replica of another, but it's quite feasible. More-over we have no actual idea what the earliest organic structures looked like, or even how they came to exist. There are dozens of viable theories on abiogenesis and none of them are currently provable - for all we know, that is exactly how the earliest replicating life began ! What were we BEFORE we were cells ? Surely we were simpler, more primitive cells with less of the features of current ones, and before that ? Well the mitochondria we have INSIDE our cells were once a seperate organism... now what used to be something alive in it's own right, is just a component of our cells. How many other components of our cells began as seperate, simpler, life form but didn't leave us fossils to conveniently prove it with ?

      This research is in fact incredibly exciting because it shows a way of experimenting with ways early life may have begun. It's using different materials - but that's actually a GOOD thing, as it stops us from trying to just recreate what we have when we don't know what, what we have, used to be. It forces us to think from scratch, as life would have started... and that IS exciting.
      More-over, if it works, if it gets far enough... it opens up entire new avenues of consideration in terms of how life may have evolved on other worlds.

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      Unicode killed the ASCII-art *
  6. Re:Complexity underestimated by gilleain · · Score: 3, Interesting

    Interesting post. I think that you are right, but for the wrong reasons.

    As you point out, a major part of the story of life is the growth in complexity. Just having a bounding membrane - Cronin's current claim - is only the first step on a long road. A key next step is - like ATP synthase - to set up an energy source. It is thought by some that the first membranes played an important role in energy capture by allowing primitive cells to set up an ion gradient across them

    The problem that I see is a lack of potential in non-carbon structures. The number of possible forms of proteins is very large; the number for polyoxometallates is larger then most inorganic forms but still smaller than organic. So he may get some steps down the road of complexity, but run out of steam (to mix metaphors!) half way there.

    Finally, crystal structures only show one feature of life : growth. If he can demonstrate self-replicating, self-repairing, self-bounding, inorganic structures then it will be life.

  7. Re:I for one by Rei · · Score: 4, Funny

    Did I say overlords? I meant protectors...

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    Man on crucifix terrorizes church, demands they eat his flesh and blood. Details at 11.
  8. We can't even synthesize carbon-based cells yet by Hentes · · Score: 3, Insightful

    What he did was inventing a metal-based soap. Wich is impressive, but very far from life.

  9. Re:Complexity underestimated by silentcoder · · Score: 3, Interesting

    >0. As for evolution, consider this: http://science.slashdot.org/story/09/02/16/0328212/Acquired-Characteristics-May-Be-Inheritable

    That is the ancient Lamarckian theorem, just because we've got reason to think that it may have some truth, it says NOTHING about evolution. If anything it strengthens it.

    >1. `many scientists today believe this was not required and there are several alternative viable theories': are they really `viable', are todays scientist all that non-error-prone?

    You're confusing meanings of "viable". Viable in this context means "could work" not "will work". They are viable in that they make sense, do not violate the known laws of nature and may be true. That is not a claim that they are correct, or that it is what actually happened - we don't have the means (at least not yet) to determine what actually happened, which is the only way to prove any such theory. Even if we used one to create new life tomorrow it wouldn't prove the theory true- it would still remain "viable" only, we'll have given it a LOT more evidence (by showing that it CAN happen that way with absolute certainty) but we would not have proven that it DID happen that way. Science is not non-error-prone, science however has incredibly high standards of testing that it uses to REMOVE errors. Where testing is impossible (or at least very difficult) theories hold less weight. That we can't know for sure if it was crystaline or clay or any of the other theories of abiogenesis doesn't weaken science, it's proof of science's resilience in that it refuses to call a theory "Fact" without being able to check.

    2> ...
    Your whole paragraph is entirely non-sensicle. Showing that the universe and life can come to exist in it's present state without a conscious creation process reduces the need to invoke a creator to explain it. All religion, including your own, came from our ancestors inabillity to explain things. Now we can explain (almost) all of them, and their explanation (some big all-powerful guy did it) holds a LOT less water.
    The simple truth is - if you believe in God, that's your right, but don't mix theology and science because they have NOTHING in common (except origins - a long, long time ago - both tried to explain the world to people). Science questions itself, religion does not - this makes them fundamentally incompatible. You can believe in God and accept science as valuable, but you cannot pretend that the one can enligthen you about the other. To reject a scientific idea on the grounds that it conflicts with religion is hypocrisy unless you are equally willing to reject a religious idea on the grounds that it conflicts with science.
    Either way you're playing a very difficult mental balancing game between a way of thinking built on rationality and demand of proof and consistent, critical self-questioning versus one built on "do and think as you are told".

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    Unicode killed the ASCII-art *
  10. Re:Complexity underestimated by silentcoder · · Score: 3, Interesting

    >Evolution is taught as a concept things changing but it makes the grand claim of things improving upon themselves to do it, by gaining complexity and self forming into "higher" life forms.

    No, it does not. Evolution simply favors that which survives the best. Sometimes it does so by REDUCING complexity. A good example: frog genomes are nearly 500 times more complex than human genomes (that is - they have about 500 times as many genes as we do). Yet frogs have been around a lot longer than we are and are way more primitive. But frog DNA has to deal with all sorts of things - a tadpole in an egg needs to develop at a certain rate, that implies chemical reactions and chemical reactions are temperature sensitive. So if it gets warmer the enzymes need to have things added that slow down the reactions, if it gets colder other things are added to speed them up. Frog DNA are filled with countless little variations of "if temperature is between X and Y add enzyme Z" for every proteine in their bodies.
    Humans (in fact all mammals) get to grow in a climate controlled environment so we have long since discarded all that extra DNA which egg-layers have. We've evolved to survive better by getting SIMPLER - not more complex.

    Most of the rest of your post is common and well debunked arguments. They are based on truth but the conclusions are false since they are massively oversimplified.

    Here's a little example of such an oversimplification. Humans (and most other mammals) contain a protein called HSP-90. HSP-90 is one of those special proteines which fold other proteins into shape. It is very rigid, and will fold them into the "orthodox" shape EVEN IF the DNA has mutated, suppressing mutations from being realized into grown cells. Call it a checker for copying errors in DNA.
    But HSP means "Heat Shock Proteine", HSP proteins are a family of proteins that the body uses in cases of sudden temperature change to help regulate our warm-blooded body temperatures. So if during early gestation there is a sudden temperature change- HSP gets diverted from folding proteins into it's "adult" job of regulating body temperature. Now the folding gets done by other folders - which lack it's rigidy and will simply do whatever the DNA says.

    Look what's happening here - usually the body will suppress mutations, they could lie dormant for thousands of years without a single person born in which they have actually been realized, there's a sudden climate change - now the body stops suppressing, mutations galore get allowed to be realized into offspring. Evolution reached the point of doing it on-demand. When there is sudden climate change, it allows every mutation it has available to occur. This is beautiful. When things are stable - stick to what's working, when things change - the species tries everything. It uses every weird mutation it has to try and produce a version that may be suited to surviving in the new conditions.
    One form of rapid speciation is triggered by HSP-90's effects. Of course MOST of those mutations die out, but if one is better suited to the sudden ice-age (or whatever) then it survives and breeds better- and once it goes to a second generation that DNA is now treated AS the orthodox, so it's not suppressed anymore. Voila - species change in a single generation. Using saved up mutations over thousands or even millions of years, that never ever showed up as organisms until the time when the world changed and sticking to "what always worked" is no longer a good idea.

    >Charles became an atheist. I think it happened when one of his children died, but I could be wrong on that.

    He died a troubled agnostic, but at the time when he was writing his grand works he was definitely a believer and in fact Origin of Species and Descent of Man both directly credit God for starting the process (multiple times). He actually held back on publishing Origin for nearly a decade because he feared that people could interpret it in ways that could harm his beloved church.

    Everything you said about i

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    Unicode killed the ASCII-art *
  11. Re:I for one by pinkushun · · Score: 3, Funny

    There truly is a God of Metal!