Slashdot Mirror


AIDS Vaccine Breakthrough

Doc Ruby writes "Scientists at Johns Hopkins University in MD, USA announced they've disrupted the means by which HIV stops the immune system from attacking it. From the article: 'Scientists say they have found a way to disarm the AIDS virus in research that could lead to a vaccine. Researchers have discovered that if they eliminate a cholesterol membrane surrounding the virus, HIV cannot disrupt communication among disease-fighting cells and the immune system returns to normal. [...] "By stealing cholesterol from the envelope of the virus, we can neutralize the subversion," said Graham. "We've broken the code; we can shut down the type of interference that HIV is having on the immune system."'"

21 of 417 comments (clear)

  1. Re:The future is here at last by Slashdot+Assistant · · Score: 3, Insightful

    I have a terrible feeling that in the future we'll be seeing cyborg homeopaths and astrologers traveling in flying cars with little fish decals proudly displayed on the back.

  2. Re:The future is here at last by wisnoskij · · Score: 3, Insightful

    I am not sure about the recent part, there have always been miracle cancer cures just around the corner for as long as I have been old enough to read the news.
    This is promising, but wake me up when they actually cure/prevent the disease in a person with this.

    And what does curing diseases have to do with cyborg augmentations?

    --
    Troll is not a replacement for I disagree.
  3. Only one to protect yourself by Adult+film+producer · · Score: 5, Funny

    Abstinence. Don't be tempted by sex unless you are 100% absolutely sure. I would suggest waiting until marriage.

    1. Re:Only one to protect yourself by Haedrian · · Score: 4, Insightful

      Laugh all you like, but if people actually took that advice a few years ago we wouldn't have AIDS anymore.

      That and "Don't share needles".

    2. Re:Only one to protect yourself by Sasayaki · · Score: 5, Insightful

      Abstinence is the worst of all the safe-sex choices.

      The best way to describe it is, "It is 100% effective, when used correctly. When not used correctly it is 0% effective, and among females and males between 14-25 it has a very high failure rate."

      How many non-Slashdot users do you know that are 25 years old and never had sex?

      --
      Check out my sci-fi book "Lacuna" at http://goo.gl/MVxX8
    3. Re:Only one to protect yourself by SuricouRaven · · Score: 3, Insightful

      This only works if:
      1. You can actually stick to it, including those hormone-addled teenage years.
      2. Your spouse (spouses, if you divorce and remarry) managed it as well.
      3. You manage to avoid other means of infection. Rape, accidential exposure to blood.

      It's also rather untidy, having to alter your life in order to avoid disease. Much tidier to simply remove the disease through science.

    4. Re:Only one to protect yourself by tverbeek · · Score: 5, Insightful

      Aye, and if my grandmother had wheels, she'd be a wagon.

      The problem with this advice – and pretty much every other "just say no" solution to a social or medical problem – is that it ignores human nature... and the empirically documented fact that it simply doesn't work. Some people inevitably will have unprotected sex, will share needles, and will do everything else that they're told not to do. A "solution" that ignores this fact is one that is not 100% effective.

      --
      http://alternatives.rzero.com/
    5. Re:Only one to protect yourself by Daetrin · · Score: 5, Insightful

      That's... 100% backwards. If i had sex with a hundred women (yeah, i'm on slashdot, i wish) got AIDS and died, but that sex resulted in a half dozen kids then natural selection would favor me a hell of a lot more than someone who practiced complete abstinence.

      Natural selection only "cares" (yes, i'm anthropomorphizing it, get over it) if you have kids and how many. It doesn't give a damn if you survive the process or not.

      --
      This Space Intentionally Left Blank
    6. Re:Only one to protect yourself by IICV · · Score: 4, Informative

      Tell that to Isaac Asimov, who died due to AIDS caused by a blood transfusion.

    7. Re:Only one to protect yourself by Nyder · · Score: 3, Insightful

      Laugh all you like, but if people actually took that advice a few years ago we wouldn't have AIDS anymore.

      That and "Don't share needles".

      Spoken like a person who lives in a glass bubble.

      We are sexual people. We don't just "turn sex off", that is not how we work.

      Instead of teaching Abstinence, we should of been teaching about proper sex health, birth control, and protection, instead of just "hoping" people will not have sex. Because people do NOT stop having sex, no matter how much you ask them not to. Can you grasp that simple concept? The religious freaks haven't.

      As for sharing needles, you once again, don't know shit.

      Why did people share needles? Because they were so fucking hard to get. Until the last 10 or so years where they have had "Needle Exchanges" and pharmacies adopting of letting anyone buy needles, it was very hard and expensive to get clean works. And when your a junkie, your money goes to your dope, not to making sure you have clean works.

      Our policies help made these problems, not the people who were stuck because of the policies.

      That fact that you are currently 4 Insightful only shows how stupid most people are about these matters. It's easy to blame others, but the blame lies with all of us for not taking care of the less fortunate in our community, not at them because they have problems that we prefer to ignore.

      --
      Be seeing you...
  4. Re:Nope, it is still in the future by durrr · · Score: 3, Insightful

    The cure for AIDS, which stands for Aquired ImmunoDeficiency Syndrome(meaning, that you have it when you have AQUIRED a immunological deficiency in case the name didn't hind at that for you) Is retroviral drugs.

    In case you have problem with neuances i'll spell it out for you. A HIV infection if left untreated will result in AIDS, at which point you're pretty much toast. A HIV infection on its own does not however qualify as AIDS with modern retroviral treatment(or the intial stage without treatment) will keep viral counts low enough that you do not Aquire any ImmunoDefciency.

    Now in fact, that's not a cure for AIDS, it's a postponing of it. As for the cure to HIV, it's not condoms. Condoms are a preventive measure against HIV, not a cure.
    Now if you excuse me I'll have to crash the moon into earth before I have to repeat this rant any more times.

  5. What do you think latex referred to? by SmallFurryCreature · · Score: 5, Informative

    I say several times UNPROTECTED sex. I mention latex explicitly. Was I being that subtle in referring to condoms?

    And the underlying cause in Africa is not sex, it is rape. Mass rape. It is an cultural attitude to women that is getting ever more brutal.

    Read a little about conditions in for instance South Africa before you go all indignant.

    --

    MMO Quests are like orgasms:

    You may solo them, I prefer them in a group.

  6. Re:The future is here at last by tverbeek · · Score: 3, Insightful

    Yeah, because that knowledge was so effective in nearly eradicating chlamydia, syphilis, gonorrhea, herpes, trichomoniasis....

    --
    http://alternatives.rzero.com/
  7. Re:The future is here at last by Electricity+Likes+Me · · Score: 3, Insightful

    Fun fact: that was largely because at first it spread amongst gay men quicker then heterosexuals, and the prevailing attitude was "great, this will finally get rid of the gays!"

    Thus governments assumed they didn't need any sort of public education campaigns about it.

    Then at some point, once someone realized straight people also have promiscuous sex (and there are tons more of them so it didn't seem like an epidemic till much later) did we decide to do anything about it.

  8. Bullshit, bullshit, bullshit by sourcerror · · Score: 5, Informative

    "Africa is both the epicenter for the disease, and is a poverty-stricken continent where people need to have families, and relatively large ones at that, in order to be taken care of in their old age. These features are sufficient to explain the sustained high infection rate without resorting to the racist twaddle you're apparently peddling. "

    Oh boy, you're so full of bullshit.

    "Medical experts have shown a clear association between HIV exposure and coerced sex. Wives who suffer violence if they request condom use or faithfulness are at higher risk of AIDS than unmarried women and girls. That is why defeating the AIDS pandemic requires a second radical proposition: that African women and girls have the right to protection under their own countries' laws.

    Why is this concept radical? Because public justice systems in many AIDS-burdened countries are broken or virtually inaccessible to poor girls and women. Rape and beatings are simply the norm, and deterrence and accountability for these crimes in Africa is as rare as AIDS drugs used to be."

    http://www.washingtonpost.com/wp-dyn/content/article/2006/08/13/AR2006081300716.html

    "Rape, including child rape, is increasing at shocking rates in South Africa. Sexual violence against children, including the raping of infants, has increased 400% over the past decade (Dempster, 2002). According to a report by BBC news, a female born in South Africa has a greater chance of being raped in her lifetime than learning how to read (Dempster, 2002). When South Africa became a democracy in 1994, there were already 18,801 cases of rape per year, but by 2001 there were 24,892 (Dempster, 2002). Numbers vary by different institutions, but are nevertheless extremely troubling. The Institute of Race Relations found that more than 52,000 rapes were reported in 2000, and 40% of the victims were under age 18 (du Venage, 2002). The University of South Africa reports that 1 million women and children are raped there each year (South Africa: Focus on the Virgin Myth, 2002)."

    http://www.medscape.com/viewarticle/444213
    http://www.scienceinafrica.co.za/2002/april/virgin.htm

    Also, big families don't cause rape, you can't catch an infection from a clean partner no matter how many times you have sex.

  9. Re:Nope, it is still in the future by vadim_t · · Score: 4, Insightful

    Problem is there is this nasty thing called "religion" whose adherents keep on insisting that condoms are somehow wrong, and that sex is for procreation only.

    A big part of the problem is all those religious jerks that are coming to those third world countries to insist on that. Fortunately they're not getting all that much traction in civilized places, but in third world countries it's devastating.

    Add to that ridiculous notions held by people in some of those countries, like that sex with a virgin will cure you, and you have one horrible mess as a result.

    Kicking out all those missionaries and bringing in some proper education would do wonders.

  10. Re:Working at FedEx by Anonymous Coward · · Score: 3, Funny

    I label all my packages HIV, I've never had one run through with a forklift or drop-kicked into a truck. Works great!

  11. Re:The future is here at last by DJRumpy · · Score: 5, Informative

    This goes beyond simple theories and pipe dreams. This was actively performed in a lab and the process is well documented. This actually pokes holes in the cholesterol membrane using a chemical called beta-cyclodextrin. This chemical binds to this special type of cholesterol around an HIV cell, which had two desired effects. It prevented the HIV virus from hyper-activating PDC's (the mechanism which damages the immune response itself), and it seems it also damaged it's ability to replicate. The chemical actually leaves the membrane riddled with holes due to this binding process.

    This is very promising in that the function they are disrupting is at the very root of what makes HIV effective in avoiding the immune system. Once this happens, the immune system is able to respond to the virus much like it would any other typical pathogen.

    The one thing that wasn't made clear was what the impact will be to those who are already infected. It sounds as if this could potentially be useful to existing infections as well but I haven't seen any statements to that effect as of yet.

  12. Re:Real or hype? by JonySuede · · Score: 3, Informative

    Here in Canada, they had a working tokamak producing an iota more than it consumed, while in steady state. When they reach that point the gov killed the project. Yes, the net balance was still negative, as it consumed a shit load of energy to get into that state and for some untold reasons, the researchers were not allowed to run it long enough to achieve a positive net balance. The tokamak name was Tokamak de Varennes.

    --
    Jehovah be praised, Oracle was not selected
  13. Re:Such an awesome crowdsourcing success! by EPAstor · · Score: 4, Informative

    Wrong breakthrough, I'm sorry to say. That one was an analysis of a protein that all retroviruses (including HIV) have - this one is an actual (albeit in vitro) treatment method. This paper is in a completely different direction, and arguably one step further along its path... and no, FoldIt was not involved in this particular breakthrough. Both are cool, but not the same work.

  14. Re:The future is here at last by GameboyRMH · · Score: 3, Interesting

    Not funny, Insightful. We could have Star Trek-level technology and we'd still suffer with the awful legacy of man's basest instincts and the old cognitive bugs from our days stalking prey and eluding predators in the jungle.

    If an AIDS vaccine were available on the market tomorrow, the right-wingers would want to stop it from being distributed, worried that it will cause autism or take the danger out of sexual promiscuity (see: HPV vaccine). Scientologists would worry that it will bring volcano spirits back into your soul or something. The alternative medicine crowd would say it's useless and a Big Pharma scam.

    --
    "When information is power, privacy is freedom" - Jah-Wren Ryel