Alzheimer's Transmission Pathway Discovered

smitty777 writes "Two separate studies by the Taub Institute and Harvard have discovered the pathway used by Alzheimer's Disease to spread through the brain. The studies indicate it's not a virus, but a distorted protein called Tau which moves from cell to cell. Further, the discovery 'may now offer scientists a way to move forward and develop a way to block tau's spread in Alzheimer's patients, said Karen Duff, a researcher at Columbia's Taub Institute for Research on Alzheimer's disease and co-author of one study published Wednesday in the journal PLoS One. "It's enlightening for us because it now provides a whole other area for potential therapeutic impact," said Duff. "It's possible that you can identify the disease and intervene (with potential tau-blocking drugs) before the dementia actually sets in."'"

Comments

Notice where the study was done

[Anonymous Coward]

It was done at a University by students who probably weren't paid. It wasn't done by a pharmaceutical lab. Remember that when the drug companies try to justify charging your parents $2000 for a one month supply of Alzheimer medication.

They spend more on advertising then R&D.

Re:Notice where the study was done

[Sockatume]

While I agree that the pharmaceutical businesses is a complete disaster area in terms of cures-per-dollar, you can't point at one publicly funded study and use it as evidence of that fact. It's spectacularly irrational.

Re:Notice where the study was done

[interkin3tic]

We shouldn't trust pharmaceuticals, that's for sure. Between the questionably ethical testing in 3rd world countries, the highway robbery, the lobbying to the medical industry to push fairly worthless products, and, oh yeah, their old-fashioned bribery (I mean lobbying) of elected officials to keep their racket going, they are evil. I got laid off from Pfizer two days after Christmas years ago, so I'm not on their side.

Still, I have to point out that basic biological research is a different beast from true medical research. Clinical trials in people are generally very expensive compared to basic research. They take much longer too. Mass producing drugs is not cheap to begin with, and the standards have to be very high for pharmecuticals. 70% purity of a drug you're going to inject into rats to test the effect for basic research like this is acceptable often, but that's hideously impure for something you're going to be putting into people.

The biggest disadvantage pharmecuticals have is liability. No one sues you if one of your lab rats or plates of cells die, this is not the case if someone taking your medicine dies. You need to hire an army of lawyers.

They do have huge costs, and the risks are much higher. Again, they should be scrutinized, but I don't think it's fair to imply that just because a university lab has a result on Alzheimers means that drugs should be cheap.

Re:Awesome

[quark101]

Alzheimer's is a terrible disease, not just for the person who has it, but especially so for those who are close to the afflicted. The slow, degenerative, wasting of the mind is horrifying to watch, as the person that was once bright and lively gets turned into a shell of their former self. Not able to grasp what's going on around them, or who they're talking to, the person can easily become terrified, lost, and confused, made all the more painful by the fact that they don't know who their children are or why they're here.

I know that identifying the underlying cause and developing a treatment are often worlds apart, but I'm glad nonetheless to see this advancement, if merely for the fact that one day others won't have to experience the pain I did as I watched people I love succumb to Alzheimer's.

Re:In America you can be cured of most diseases

[crmarvin42]

That was his own fault. He decided to try homeopathic voodoo instead of sound, scientifically-validated methods to treat his cancer initially. That resulted in an early diagnosis (with high probablity of complete remission) turning into a late treatment (with far less favorable odds). The key with most agressive cancers is early diagnosis AND early treatment.

Cases like this are where homeopathy changes from being mostly harmless, and therefore not worthy of much attention, and become outright dangerous.