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Paralyzed Man Regains Hand Function After Breakthrough Nerve Rewiring Procedure

An anonymous reader writes "A 71-year-old man who became paralyzed from the waist down and lost all use of both hands in a 2008 car accident has regained motor function in his fingers after doctors rewired his nerves to bypass the damaged ones in a pioneering surgical procedure, according to a case study published on Tuesday."

19 of 56 comments (clear)

  1. Fact is becoming better than fiction by jcrb · · Score: 4, Interesting

    Between this, the latest reports of restoring sigh with implantable photo voltaic chips and engineered nano particle drug delivery, medical science fiction is running out of subjects that are still fiction. Kurzweil's Singularity is looking more and more likely every day.

    In the words of Glenn Reynolds ...... FASTER, PLEASE!!

    --
    -jon
    1. Re:Fact is becoming better than fiction by rrohbeck · · Score: 3, Funny

      Sigh.

  2. No dexterity in the fingers by cortex · · Score: 4, Informative

    Pretty amazing surgery, but watching the videos shows limited restoration of function. The key is getting the transplanted/regenerating nerves to make the proper connections. The surgery is not going to re-wire the incredible number of connections made during development. Neural prostheses currently offer better dexterity and restoration of function than the nerve transplant. However, it is likely only a matter of time (maybe sever decades) before the neural re-wiring problem is solved.

    1. Re:No dexterity in the fingers by crash123 · · Score: 5, Insightful

      You have to remember that this operation probably caused nerve damage too and nerves take a ridiculously long time to heal (about 6mm per week) also the dude hasn't used his hand in four years so he has probably just forgotten how to use it too. He will have a lot of rehab ahead of him i imagine.

    2. Re:No dexterity in the fingers by Neil+Boekend · · Score: 3, Informative

      Don't forget: the nerves they connected the hand to were not meant to be used for this. They wired an "arm up and down" nerve to a "close and open hand" nerve. The brain can adapt and send the new data, but this takes time. Imagine the weirdness when you want to close your hand and had to lift your arm to send that signal. Now you need to learn you should only use one of the muscles involved in lifting your arm, because otherwise you'll lift your arm.

      --
      Well, I might have a way, but it only works on a semi spherical planet in a vacuum.
    3. Re:No dexterity in the fingers by anerki · · Score: 2

      It's far too early to already conclude that reqained functionality is minimal or not worth the risk.

      The human nerve system could be compared to the central phone systems of a long time ago where you had an operator that would connect you (where your line inserted) to where you wanted to go by just replugging your cable.

      The human or animal body does much the same. It will check what the connections are, and over time optimise them or redirect them if their function has changed.

      This was proven a long time ago on some type of animal, I forgot which but it was some mammal (sadly, references are missing too), where they swapped the connections of the legs in the nerve system. It only took the dogs a couple of days to naturally adapt and they would no longer notice the difference. The same goes for the eyes btw, the connections in our brain are reversed, it's assumed that very early one babies see everything upside down (like you do in a camera, it's the same effect of lenses causing it (a lens swaps the image)) but the brain just compensates, redirects and you no longer notice it.

      If for some medical reason, it swaps (and it has occured), the brain will take a couple of days to compensate and then adjust to the 'new normal'.

      Hopefully for the person who underwent the surgery, he'll see an improvement soon ...

      --
      Life is great! (as told by Lady Susan)
    4. Re:No dexterity in the fingers by Electricity+Likes+Me · · Score: 3, Insightful

      Conversely the brain's body map is actually incredibly malleable anyway - since it expands and contracts to deal with tools you're using and transitioning to or from. People wince when they scrape their car, because in a very real sense they feel like they hit a part of themselves.

      With time (and well, it's definitely a permanent part of him) I suspect he could recover full function to the point of not needing to think about it.

  3. Qaelia sensory mapping by Anonymous Coward · · Score: 5, Insightful

    "The brain has to be trained to think, 'OK, I used to bend my elbow with this nerve, and now I use it to pinch' [...] it's more of a mental game that patients have to play with themselves."

    I love imagining just how this would feel. Does the wiring ever become automatic and abstract in the same way that we normally come to experience motor movements(not thinking about pulling this muscle, relaxing that one, but just that we want to move our leg)? Or will he for the rest of his life feel like he is trying to move a specific forearm muscle group when he scratches his head?

    1. Re:Qaelia sensory mapping by durrr · · Score: 4, Interesting

      It becomes abstract and automated. Sortof like how your brain can flip your vision if you wear inverting glasses for prolonged timeperiods.

    2. Re:Qaelia sensory mapping by Fluffeh · · Score: 3, Informative

      If anyone was curious like me for a proper article on these upside-down glasses experiments, here is a link though be warned that it is a PDF.

      --
      Moved to http://soylentnews.org/. You are invited to join us too!
  4. Gentlemen, we can rebuild him. by Will+Steinhelm · · Score: 5, Funny

    Gentlemen, we can rebuild him. We have the technology. Better than he was before. Better, stronger, faster.

    1. Re:Gentlemen, we can rebuild him. by gijoel · · Score: 2

      I don't know there would definitely be a downside to having your hand making that whirring and eh-eh-eh-eh noise every time you masturbated.

  5. I had these nerve rewirings in 1998 too... by antdude · · Score: 5, Interesting

    Reposted and updated from http://science.slashdot.org/comments.pl?sid=8937&cid=613380 ...

    When I had my cranial surgery (due to my locked jaw -- had to open my jaw -- it was so bad that I couldn't stick my tongue out), the doctors had to break some nerves to fix this (from my neck and right side of my head near the ear area).

    After the complex surgery, the right side of my face were unresponsive (i.e. couldn't move and feel). That included my right eye where I couldn't move my eye lids (not even close fully).

    After about two months, I went to another surgery to fix these damaged facial nerves. The doctors fixed this by connecting working nerves to the damaged ones. Basically, they were rerouting these signals as if you were rerouting a network.

    Some of my broken nerves are currently recovered, but it will take years to recovered almost fully (not 100%).

    You can read more old details from http://zimage.com/~ant/antfarm/about/surgery/surgery.html ...

    --

    5/15/2012: Nope, they never recovered fully. I still can't close my right eye lid fully and can feel a little more, but still can't move fully. The feelings still funky in other areas on my head/face/neck. Heh!

    I wonder how much has improved from 1998 if I had that nerve reconstruction in 2010s.

    --
    Ant(Dude) @ Quality Foraged Links (AQFL.net) & The Ant Farm (antfarm.ma.cx / antfarm.home.dhs.org).
  6. Re:Cloning by Rosco+P.+Coltrane · · Score: 2

    How is cloning gonna help anything? The problem isn't obtaining nerves, it's connecting them.

    Think of it like this but at microscopic level, and with no labels on the cables to figure out what should be connected to what.

    --
    "A door is what a dog is perpetually on the wrong side of" - Ogden Nash
  7. Re:I'm not a doctor by Razgorov+Prikazka · · Score: 5, Informative

    A new procedure is a (usually) physical procedure on 1 single person who is consenting. If it goes wrong only 1 person is harmed (or not improving at least)
    A new drug is something (bio)chemical of which the long term implications are more difficult to oversee. Aspirin is with us now since 1860 or so and still we find out new benefits and drawbacks of it. Further still, it is to be given as a treatment to a much larger set of individuals, so the potential harm done is therefore greater and thus needs more and rigorous testing before it can be deployed.
    So I think (although I am not at all a medic) that therefore the consent of only the patient is enough if the applicable law's and Hipocratic oath is not broken in such matters.

    --
    rm -rf --no-preserve-root / ...and let /dev/null sort them out...
  8. Re:I'm not a doctor by Impy+the+Impiuos+Imp · · Score: 3, Interesting

    That's good chin-rubbing reasoning. Should it rule the day, though?

    How many people would die because drugs and procedures got onto the market too fast?

    Compare that to how many die because good drugs get delayed by a year or two or five or ten.

    I wouldn't be so quick to jump on the FDA-saves-lives bandwagon. They could turn out to be one of the biggest mass-murders, net, in all history.

    --
    (-1: Post disagrees with my already-settled worldview) is not a valid mod option.
  9. Re:I'm not a doctor by Charliemopps · · Score: 3, Insightful

    The FDA is just an arm of the pharmaceutical companies. The majority of the people that work at the FDA either worked for the companies they regulate in the past, or will work for them after they leave the FDA. Just like most of the branches of our federal government they are corrupt through and through. Could they regulate effectively? Sure! Do they? no. Why don't they regulate "Supplements"? Why do they regulate so many rudimentary anti-inflammatory drugs that have no addictive properties at all? Why can I get enough Tylenol at a gas station to kill 10 people but my asthma inhaler I need a prescription for? Because the FDAs primary role is NOT to keep us safe. It's to keep the drug companies products scarce and drive up their price.

  10. Re:I'm not a doctor by mcgrew · · Score: 3, Informative

    The majority of the people that work at the FDA either worked for the companies they regulate in the past, or will work for them after they leave the FDA

    Well, if I were running a drug comapny I would want someone who knows the ins and outs of the bureaucracy, and if I were running a regulatory agency I'd want to hire someone who knows the ins and outs of the industry.

    Why don't they regulate "Supplements"?

    Because the law doesn't allow them to. That's not the FDA's fault, that's your legislator's fault.

    Why do they regulate so many rudimentary anti-inflammatory drugs that have no addictive properties at all?

    Because too much aspirin or too much Naproxin Sodium can eat a hole in your intestine wall, and too much acetominaphin (which I don't know how to spell) can ruin your liver. A better question is why they're not regulating addictive drugs like alcohol and tobacco. Of course the reason is because they're regulated by the ATF (which I think should be abolished).

    Why can I get enough Tylenol at a gas station to kill 10 people but my asthma inhaler I need a prescription for?

    Because the asthma inhaler has steroids, and steroids can do a LOT of things to really fuck you up real good; for instance, steroid eyedrops will give you cataracts (I found this out when I was prescribed them for an eye infection and wound up getting cataract surgery in that eye as a result; it was the eye doctor that told me the steroids caused the cataract).

    Get rid of the FDA and you're going to see a hell of a lot more worthless snake oil on the market, which is why the FDA was started in the first place.

    Does the tinfoil hat work best shiny side in or shiny side out?

  11. Re:I'm not a doctor by ravenshrike · · Score: 2

    If they abolish the BATFE, who's going to give guns to the mexican drug cartels?