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"Mini-Factories" To Make Medicine Inside the Body

Diggester writes "A group of scientists from MIT and the University of British Columbia have created 'mini-factories' that can be programmed to produce different types of proteins, and when implanted into living cells, it should distribute those proteins throughout the body. The scientists have initially triggered these 'factories' into action through the use of a laser light to relay the message of which proteins to produce."

49 of 79 comments (clear)

  1. Pharmaceutical Lobbyists by Anonymous Coward · · Score: 2, Interesting

    Just wait until the pharmaceutical lobbyists get our clueless lawmakers to make protein synthesis illegal.. Then, the next step will be to make the lymphatic system illegal too. Illegal copying of cells is a violation of copyright law.

    1. Re:Pharmaceutical Lobbyists by MagusSlurpy · · Score: 3, Insightful

      You realize who's going to make a killing manufacturing these nanofactories, right? The pharmaceutical industry. Even more amusingly, look at who funds the facility where most of the research took place. Yes, those Koch Brothers.

      Go pander your conspiracies somewhere else.

      --
      My sister opened a computer store in Hawaii. She sells C shells by the seashore.
    2. Re:Pharmaceutical Lobbyists by Tubal-Cain · · Score: 1

      The scientists have initially triggered these 'factories' into action through the use of a laser light to relay the message of which proteins to produce.

      Treatment will be $500. Now go put your hand under the blinking light. Okay, all done!

    3. Re:Pharmaceutical Lobbyists by BlackSnake112 · · Score: 1

      Just wait until the pharmaceutical lobbyists get our clueless lawmakers to make protein synthesis illegal.. Then, the next step will be to make the lymphatic system illegal too. Illegal copying of cells is a violation of copyright law.

      You mean people will have to get permission to have kids? Please let that happen. Watching/reading the news about how hard it is to enforce will be funny. A pregnant woman crosses/lands into the country, police STOP! Do you have permission to duplicate those cells? Here is your $1000 fine. The lady swings what ever she is carrying and smacks the police officer in their head. It will be like a 3 stooges comedy routine, only funnier.

    4. Re:Pharmaceutical Lobbyists by Fned · · Score: 1

      "a laser light to relay the message of which proteins to produce"

      Yes, those Koch Brothers.

      My guess is the Koch Brothers' new "painful-death-by-simultaneous-rapid-growth-tumors-everywhere-in-your-body-at-once-don't-you-wish-you'd-read-the-fine-print-employee-attitude-adjustment laser" is going to make one of Baron Harkonnen's heartplugs look like a fucking employment benefit.

    5. Re:Pharmaceutical Lobbyists by uninformedLuddite · · Score: 1

      Doesn't Mom have prior art as she wanted to use third world kid's bodies as manufacturing plants years ago.

      --
      The new right fascists are bilingual. They speak English and Bullshit.
  2. Cool. by Anonymous Coward · · Score: 1

    Now when can i get one implanted that makes THC?

    captcha:conveyor

    1. Re:Cool. by Teresita · · Score: 1

      Only in states with medical marijuana laws, like this one.

    2. Re:Cool. by Mindcontrolled · · Score: 1

      Your body does build Anandamide, however, which triggers the same receptor as THC - so, instead of a THC microfab in your body, just find something to trigger anandamide release. Or, more easily, smoke a spliff... ;)

      --
      Ubi solitudinem faciunt, pacem appellant.
    3. Re:Cool. by kermidge · · Score: 2

      "DMT is the psychedelic used in LSD."

      Uh, no: http://en.wikipedia.org/wiki/Lsd

      I took plenty of acid '67-'77, ain't no DMT to it. Were occasional rumors some chemists added stuff to their blotter or whatnot, but I never saw any. Helps to know good chemists. ;)

    4. Re:Cool. by kermidge · · Score: 1

      I don't think I ever knew that, good info to file away. Thanks.

    5. Re:Cool. by kermidge · · Score: 1

      Forgot to say, I dig your sig.

    6. Re:Cool. by ohsmeguk · · Score: 1

      Hey buddy, although DMT and LSD share the same indole ring structure, they are very different chemicals (and experiences). Just to be clear, DMT is not used in the manufacture of LSD

    7. Re:Cool. by Eponymous+Hero · · Score: 1

      as an aside, the word "anand" or "ananda" means bliss in several hindi dialects.

      --
      insensitive clod overlords obligatory xkcd car analogy russian reversals whoosh pedant fanbois ftfy in 3...2...1..PROFIT
    8. Re:Cool. by uninformedLuddite · · Score: 1

      You would be horrified if you saw what the kids these days put into their bodies when they take a 'trip'. Mmmmmmmmmmmmmm-memories of microdots

      --
      The new right fascists are bilingual. They speak English and Bullshit.
  3. I wonder.. by Anonymous Coward · · Score: 2, Interesting

    I wonder if they could make these factories produce insulin, dependent on concentration of glucose? That would be cool for diabetics.

    1. Re:I wonder.. by Anonymous Coward · · Score: 1

      I was thinking Type 1 diabetics, they tend to be skinny, and develop the problem in childhood due to autoimmune attack on the pancreas. The fat ones who eat their way to diabetes you're thinking of tend to be insulin resistant and so wouldn't be helped as much.

      Please don't lump T1DM and T2DM together, the disease process is entirely different, and it's not fair to the T1DM patients to assume they ate their way into the disease.

    2. Re:I wonder.. by FreedomOfThought · · Score: 2

      Except I think it mightn't be necessary since there is another, more efficient, idea that seems to be promising.

    3. Re:I wonder.. by NEDHead · · Score: 1

      Not a problem.

      A company as sensitive as Walmart is to the needs of its customer base would quickly install larger doors. And initiate One-Way aisles to avoid congestion.

    4. Re:I wonder.. by slazzy · · Score: 2

      Insulin is a protein like many hormones so I'm sure this is something they are thinking about.

      --
      Website Just Down For Me? Find out
    5. Re:I wonder.. by wealthychef · · Score: 1

      Actually, the good news for diabetics is already here

      --
      Currently hooked on AMP
    6. Re:I wonder.. by axlr8or · · Score: 1

      No, please. Don't stop his logic. With that kind of natural ability he is sure to solve all the worlds problems. Let him insult.

    7. Re:I wonder.. by uninformedLuddite · · Score: 1

      The simple solution is bigger doors at Wal Mart

      --
      The new right fascists are bilingual. They speak English and Bullshit.
    8. Re:I wonder.. by uninformedLuddite · · Score: 1

      I post a reply and the very next comment I read is essentially what I posted. The one way aisles is a good one although I suspect some of them become one way automatically when a particularly large heifer gets through.

      --
      The new right fascists are bilingual. They speak English and Bullshit.
  4. WCPGW by mattr · · Score: 1

    What could possibly go wrong. This is cool and wave of future but I'll sit back as long as I can to wait for bug testing.

    1. Re:WCPGW by Teresita · · Score: 1

      Fast forward to Los Angelese, November 2019. Tyrell Corporation asserts their 2010 patent for "single click" RNA transcription. A judge orders that the Genentech nanofactories keeping the subject alive have to be de-activated for patent infringement. The subject is dead before he leaves the table.

    2. Re:WCPGW by __aaltlg1547 · · Score: 1

      And how are they going to shine those lasers in my liver?

  5. Nanohives by WillDraven · · Score: 3, Insightful

    Did anybody else think of nanohives from Shadowrun when they read the title?

    --
    This is my sig. There are many like it but this one is mine.
    1. Re:Nanohives by Intrepid+imaginaut · · Score: 3, Interesting

      Its definetely moving into a cyberpunk future. /slap on mirrorshades

    2. Re:Nanohives by L4t3r4lu5 · · Score: 1

      Actually I thought of 'glanding' as per Iain M. Banks' Culture series.

      --
      Finally had enough. Come see us over at https://soylentnews.org/
  6. Wow, it's like a simple cell by NotSoHeavyD3 · · Score: 2

    I mean how a cell (like bacteria) have a bit of DNA, mechanism to transcribe that to RNA and use rhibosomes to translate that into a protein. This thing does similar stuff except it isn't designed to replicate itself. Hmm, I don't have access to the original though, what does it use for energy to do all of this? (Since a cell might use a mitochondria to do cellular respiration. Ok, a bacteria doesn't have those but it can do something similar.)

    --
    Did you know 80 to 90% of the moderators on slashdot wouldn't recognize a troll even if one dragged them under a bridge.
    1. Re:Wow, it's like a simple cell by glk572 · · Score: 3, Informative

      skimmed the O, what they've done is combine two methods; essentially they've created an artificial cell wall and populated it's innards with the cellular machinery from e. coli bacteria. then they've introduced a piece of dna for the protein they're looking for. the factory claim comes from claims that the hybrid cells can still produce proteins under turbulence of the blood stream.
      as far as i can tell they don't know where the energy is coming from, the action dies out after around 24 hours. these letters are usually incremental publications, it's very short and excludes most of the details, this may be just experimental error, there's no reason to suspect that this is potentially superior to conventional mab techniques, or is in any way safe to use in vivo. they look like they're looking for a mechanism right now, but this is mostly academic work, basic research, and most of all ignores the complexity of the mammalian immune system.
      this is being published now for the sake of shopping it around for more grant money. if you want the O and can figure out how to get me your email, i can send a limited number of copies.

      --
      Well art is art isn't it, but then again water is water; and east is east; and west is west; and if you take cranberries
  7. The next step! by Commontwist · · Score: 1

    Woot! Another step towards improving the human immune system. Something like this sounds oddly similar to something I said last October:

    "It would be nice if one could program the current immune system with a broad range identifier would eliminate all but the rarest of virus infections. Then the next step would be to somehow analyze foreign invaders to give scientists advance warning. Then a way to create fixes automatically. David Weber gave a shot at imagining something like that but with alien tech implants and nanotech in his Troy series. Some DNA rewriting in the first book as well. How accurate he was I leave to you."

    The 'way to create fixes automatically' part would fit in well with this article. Now they just need a detection method, a way to communicate to the human host, and something to link it all together. Whee!

  8. Mini factories... by fahrbot-bot · · Score: 1

    I'm going to save a ton of cash and outsource mine to India.

    --
    It must have been something you assimilated. . . .
  9. nice job reframing by khipu · · Score: 4, Insightful

    Don't get me wrong, this is a nice achievement.

    But calling this "mini-factories", "programming", and "nanotechnology" is a clever reframing to make a combination of standard molecular biology techniques that are very far from actual medical use appear more hip and high tech.

  10. I smoke like crazy and wouldn't want that! by Anonymous Coward · · Score: 2, Interesting

    Not going to happen and you wouldn't want arbitrary amounts of THC in your system all the time either.
    I know.. I'm on week 8 of my toke break and starting to be able to do some work again. Couldn't sit down
    and type for a long while, was about to lose my job. I started getting better by week 6. Even THC is not
    something you want to abuse too much, it is fat solvable and stored in body fat and I still feel like I'm
    high sometimes.

    Don't get me wrong, THC is still an infinitely superior alternative to anything big pharma wants to put into
    you, it is a fantastic anti-depressant, controls blood pressure, moderates your immune-system (if it's too
    depressed it ramps it up, if it is switched on "too high" it dampens it just like Vitamin D3 does incidentally)
    and gives you anti-government thoughts and other insights into life and the universe. On the downside it
    can build up in your system, destroy your concentration and it takes away your dreams during REM which
    may be a huge issue all by itself. It also makes you superlazy. I know. I've smoked A LOT and at some point
    the dosage you need to get high enough is also the dosage that gives you negative side effects. However that
    is me smoking weed like some people smoke cigarettes so any anti-marijuana zealots lying out their asses,
    don't quote me for I understand the upsides and downsides none to well both from having consumed it
    and from having stopped it.

    I'm week 8 of the toke break out of 12 and no there are no huge withdrawal effects (as it is still released in
    my system slowly), I got no huge cravings for it and I'm quiet a bit more active and yes dreams have come
    back. I'm also slightly less lazy probably coming down to my natural ingrained level of laziness at this point.
    Oh I'll be back to smoking in a few weeks, on the weekends after dark because I do not want to miss out
    either on the health benefits nor of course on getting high every so often but one thing I know for sure is
    I would not want anything in my system that produces THC all the time ... like I said there's a downside to it too
    if things get out of hand.

    1. Re:I smoke like crazy and wouldn't want that! by uninformedLuddite · · Score: 1

      I would be posting anonymously too if I was going to claim withdrawal effects from smoking weed. The only sufferers of withdrawal from stopping smoking weed are weak minded, propaganda believing anonymous cowards (or those in the pay of the drug war).

      --
      The new right fascists are bilingual. They speak English and Bullshit.
  11. Re:Imagine the possibilities! by BlueStrat · · Score: 3, Insightful

    Just imagine soldiers and ordinary people with implants to make steroids inside the muscles and painkillers dripped directly the bloodstream without all those icky syringes!

    I'm imagining an entire populace government-healthcare-mandated to have these laser-controlled nanofactories that can, besides their publicized abilities, also produce mild or heavy tranquilizers, or other mind/mood-altering drugs.

    People protesting? Flash a laser and they're not so interested any more...can't really remember what it was they were mad about. Violent mob? Flash, and they fall unconscious. Government/police wants to question someone? Flash, and they get a dose of sodium pentathol or other similar drug. Government wants to set-up someone? Flash, and they get a nice big dose of rohypnol ("rufies") and star in an embarrassing video they don't/can't remember.

    There's huge potential for abuse here.

    Strat

    --
    Progressivism (aka US 'Liberalism'): Ideas so good they need a police/surveillance-state to enforce.
  12. yeah. it's called by Ralph+Spoilsport · · Score: 1

    organic unprocessed whole FOOD.

    --
    Shoes for Industry. Shoes for the Dead.
  13. Hac-hac-cough-cough by pubwvj · · Score: 1

    Hackable people.

  14. Re:Imagine the possibilities! by BlueStrat · · Score: 4, Interesting

    I see my post got modded "Troll".

    To those who think I'm trolling, I'm not.

    Just think for a minute: What kind of wet-dream would it be for the government's "War On Some Drugs & Poor People" types to be able to make it mandatory that everyone's implants time-release constant levels of medications & proteins that would prevent a person from getting "high" from illegal substances? Or even make them violently-ill? They already make pills that make someone violently ill if they drink alcohol to treat alcoholics.

    Looking back over the past, do you really trust them not to go that far. or try like hell to? Especially after a few decades?

    Who gets to control the implant(s)? Can the control be overridden/hacked? How do you secure that control? How can you be sure that what they tell you it can do is all it can do?

    Frankly, without so much security and personal control protections built in that it almost makes it useless for emergency-type patient-unconscious-or-unresponsive scenarios, this concept scares the crap out of me.

    Strat

    --
    Progressivism (aka US 'Liberalism'): Ideas so good they need a police/surveillance-state to enforce.
  15. Still need an external device by manu0601 · · Score: 1

    But the nanoparticles still have to be pumped in the body, so this will not remove the need for device like insulin pump.

  16. Re:Imagine the possibilities! by PiratePete1911 · · Score: 1

    It will be fine once we figure out how to Jailbreak ourselves.

  17. Re:Imagine the possibilities! by BlueStrat · · Score: 2

    t will be fine once we figure out how to Jailbreak ourselves.

    Just beware of that "early termination" clause for unauthorized access!! I'd hate for my body chemistry to "get bricked", as it were. ;)

    Strat

    --
    Progressivism (aka US 'Liberalism'): Ideas so good they need a police/surveillance-state to enforce.
  18. Re:Imagine the possibilities! by gutnor · · Score: 1

    So you also miss the good old days playing Syndicate :-)

  19. Re:Imagine the possibilities! by sohmc · · Score: 1

    I didn't mod your post but I can see why someone would have flagged it troll. It's a bit snarky. ;-)

    However, your point is still valid and came to post this exact point: will you have a choice to not accept these "ultraviolet rays"? As much as we would like to, we don't control what our cells do. And there is a lot of good that this technology can do. How long until this becomes weaponized and used not only to cure, but also to control?

    I will admit, however, there is some time before this debate absolutely needs to happen, This doesn't mean that it shouldn't happen now. If all it takes is ultraviolet radiation to program the cells, all it takes is some paranoid politician or evil genius to just pump people full of insulin to make them have a coma.

    --
    We don't live in Shouldland.
  20. Re:Imagine the possibilities! by BlueStrat · · Score: 2

    I didn't mod your post but I can see why someone would have flagged it troll. It's a bit snarky. ;-)

    I just don't see any "snark" there. Maybe my "snark-ometer" needs recalibration. The only thing I see that someone could get their panties in a twist over is the mention of government-run healthcare as the vehicle for universal mandatory adoption. I simply thought it current, topical, and relevant in keeping with the recent SCOTUS decision.

    If that's the case, someone needs to learn to be a little less thin-skinned. It wasn't a political bash. Trust me. Anyone familiar with my past posts would know that, when I DO come down on something, there's no doubt about it. I don't mince words, and I don't mind calling a spade a spade regardless of BS PC etiquette or delicate Liberal/Progressive sensibilities.

    This ain't that.

    Strat

    --
    Progressivism (aka US 'Liberalism'): Ideas so good they need a police/surveillance-state to enforce.
  21. Re:Imagine the possibilities! by thesandtiger · · Score: 1

    The thing is, it wouldn't really enable much in the way of behaviors that the governments of the world can't do right now, if they feel like it.

    It would be a fairly trivial task to simply fake a video of someone who they want to set up, or why even bother with that when it's even easier: "So and so was found to have large amounts of child pornography on their system" and said person is basically fucked for life.Who needs to roofie them?

    Sonic weapons, tear gas, other "less than lethal" tools are being used against protesters and even when they are completely abused and police are caught on camera doing horrible shit, nobody cares. Remember that veteran who had his skull cracked during the OWS protests and it was caught on film? Or how about that woman in the wheel chair who was simply trying to get away but was tear gassed and pepper sprayed and that was caught on video? Or how about those protesters who were kneeling, hands on head, and that cop walked by spraying them in the face? Nobody gives a shit except for the people protesting and a few others. We don't need a pharmacopia to turn people passive as clearly they already are.

    I don't disagree that there is the potential for abuse, but not much more really than is currently available by any number of methods, and it doesn't seem like there's much of a need for it.

    --
    Since I can't tell them apart, I treat all ACs as the same person.
  22. Re:Imagine the possibilities! by Fned · · Score: 1

    I see my post got modded "Troll".

    To those who think I'm trolling, I'm not.

    Just think for a minute: What kind of wet-dream would it be for the government's "War On Some Drugs & Poor People" types to be able to make it mandatory that everyone's implants time-release constant levels of medications & proteins that would prevent a person from getting "high" from illegal substances? Or even make them violently-ill?

    Wait, do you somehow imagine that the War on Drugs is to stop people from taking the illegal substances?!? Here are the top five lobbyists against drug legalization:

    1) Police Unions. They get big budgets and more powers every year the drug war goes on. If it stops, the gravy trough dries up. They would hate this.
    2) Private Prison Industry. If people aren't taking illegal drugs, we can't put them in prison, and the gravy trough dries up. They would also hate this.
    3) Alcohol Industry. These guys probably wouldn't mind -- PROVIDED the implants don't affect your ability to enjoy alcohol.
    4) Pharmaceutical Industry. These guys would DEFINITELY have a problem - no cocaine, no Prozac; no heroin, no Vicodin. It would be a nifty trick to selectively block some specific serotonin uptake reinhibitors or opiates but not others...
    5) Prison guard unions. See 2 above, but throw in government-run prisons as well.