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Nanoparticle Completely Eradicates Hepatitis C Virus

Diggester writes "While Americans worry every year about getting a flu shot or preventing HIV/AIDS, the deadlier silent killer is actually Hepatitis C, killing over 15,000 people yearly in the U.S. since 2007 — and the numbers continue to increase as the carriers increase in age. While there is no vaccine, there is hope in nanoparticle technology. The breakthrough came from a group of researchers at the University of Florida, creating a 'nanozyme' that eliminates the Hep C 100% of the time; before now, the six-month treatment would only work about half the time. The particles are coated with two biological agents, the identifier and the destroyer; the identifier recognizes the virus and sends the destroyer off to eliminate the mRNA which allows Hep C to replicate." Reader Joiseybill adds a link to coverage in the IEEE Spectrum, and points out that the 100 percent success rate, while encouraging, is so far only in the lab.

31 of 104 comments (clear)

  1. Deadlier? by Anonymous Coward · · Score: 5, Informative

    "While Americans worry every year about getting a flu shot or preventing HIV/AIDS, the deadlier silent killer is actually Hepatitis C, killing over 15,000 ..."

    The flu kills each year an average number of 25000-36000 people in the US, depending on the statistics.
    http://www.cdc.gov/flu/about/disease/us_flu-related_deaths.htm

    1. Re:Deadlier? by ketamine-bp · · Score: 5, Informative

      the deal with these is that flu, pneumonia and perhaps urinary tract infection is almost always the presentation of the patient in the death episode. it's not fair comparing it to flu. Among those who died of flu, it is rather rare to find a person who enjoyed relatively good past health and is young.

      Hepatitis C (and hepatitis B), on the other hand, leads to cirrhosis, hepatocellular cellular carcinoma and liver failure. It is exactly one of those diseases which will cause deterioration of the patient's health to such extent that a flu could kill.

      It is rather unfair to compare Hep C to Flu in terms of mortality.

    2. Re:Deadlier? by Nyder · · Score: 5, Insightful

      "While Americans worry every year about getting a flu shot or preventing HIV/AIDS, the deadlier silent killer is actually Hepatitis C, killing over 15,000 ..."

      The flu kills each year an average number of 25000-36000 people in the US, depending on the statistics.
      http://www.cdc.gov/flu/about/disease/us_flu-related_deaths.htm

      the flu kills more then terrorist, yet we spend more money defending against terrorist.

      wtf?

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    3. Re:Deadlier? by durrr · · Score: 4, Informative

      Hepatitis viral infections are also not self-limiting, hep C is pretty ugly too in that it limits transplant options(read; hep c = no transplants for you) which can be a pretty shitty situation for kidney transplant candidates that can get infected by dialysis catethers and whatnot and be excluded from the queue.

      Hep B is pretty nasty too, hard to treat, survives well in the outside environment and about as virulent as a cat video on youtube.

    4. Re:Deadlier? by camperdave · · Score: 2, Funny

      It's the military industrial complex. Terrorism gives them an excuse to exist and siphon off tax dollars. Force all arms manufacturers to be not-for-profit companies, and your terrorism threat will vanish like a juice stain in an informercial.

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    5. Re:Deadlier? by RenderSeven · · Score: 3, Interesting

      Try the nose drops. I've had similar experience with the shots but very good results with the drops.

    6. Re:Deadlier? by X0563511 · · Score: 2

      Likewise. Getting a flu shot makes me feel terrible for a week, and I've yet (knock on wood) to get it since I stopped getting the shots.

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  2. Easy by Anonymous Coward · · Score: 5, Funny

    the 100 percent success rate, while encouraging, is so far only in the lab

    So take everyone to the lab for treatment. Duh.

    1. Re:Easy by Impy+the+Impiuos+Imp · · Score: 4, Funny

      Only if you're at risk. As this is a sexually transmitted disease and this is Slashdot...

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    2. Re:Easy by Anonymous Coward · · Score: 3, Insightful

      Excuse me, but not all needle users are junkies. Tainted blood supplies in the early 70's gave it to me. I hope this "cure" is gentler than Interon+ribaviron.

    3. Re:Easy by robably · · Score: 4, Insightful

      why are we worried about this if the only ones who will really benefit are drug users?

      What a cunt. They're human beings.

      You think people who take drugs don't deserve to live? Fine. Go and live in a world without all the music, books and films created by drug users. No more Rolling Stones for you. No more Burroughs. No more Blake or Shelley. No Hunter S Thompson. No Carl Sagan. None of the beauty and insights and technical leaps forward that people who take drugs have given the world.

      In fact, no more computers for you. Piss off.

    4. Re:Easy by muridae · · Score: 2

      It's only sexually transmitted if one of the people was shooting up.

      Allow me to add: fuck you.

      The only needles I ever had in my veins were in the hospital, and unless they were shooting me up with heroin in used needles at age 2, your drug use reference is insulting, wrong, and simply moronic.

      Realize this: until the 1989, Hep C wasn't even a recognized virus; at least as far as the patient was concerned. The diagnosis was viral non-A non-B hepatitis. Whether it was even contagious, or how it was transmitted other than blood-to-blood was not known; how long you were infectious wasn't know; whether the virus was only there when symptoms were apparent or whether it stayed active but hidden wasn't really known. I don't even have a blood transfusion on record, clean family all around, and somehow still managed to contract it as a child. Mid-90s they developed a PCR test that could tell you that you had it. And then they learned that not all non-A non-B was C viral (see Hep-D and Hep-E, GBvirusC). See this article from two years ago to see that in 20% of cases, the source of infection isn't even known!

      So, in conclusion, piss off wanker

  3. mice or men by mynamestolen · · Score: 5, Funny

    would have been nice for mice to be mentioned in the summary since it appears only to apply to them. lucky dogs

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    1. Re:mice or men by OzPeter · · Score: 2

      would have been nice for mice to be mentioned in the summary since it appears only to apply to them. lucky dogs

      Lucky dogs??!?! How would you like your assigned tasks from your boss to consist of:
       
      1. Get infected with contagious disease
      2. Try out some cures to see if they work
      3. ????
      4. Profit! (well - for your boss that is)

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  4. It is wonderful, but it's only in mice by ketamine-bp · · Score: 4, Insightful

    Well, there are more than a hundred discoveries like these that demonstrated effectiveness of curing the uncurables in the past decade. Of those which went through the testing in man, well, maybe 2 or 3...

    Back then, avastin, glivec and so on were expected to be magical cures for cancers.. now they exist only as expensive life-prolonging (with or without quality) therapy and only for those who are rich.

    1. Re:It is wonderful, but it's only in mice by gpmanrpi · · Score: 3, Informative

      Gleevac (Imatinib) makes Ph+ CML a manageable livable Chronic Disease, instead of dying very rapidly. While it is expensive and "life-prolonging," it is very life-prolonging. And there are other TKIs that can now be taken if there is drug-resistance. http://en.wikipedia.org/wiki/Discovery_and_development_of_Bcr-Abl_tyrosine_kinase_inhibitors Many of these drugs are in Phase II trials. The problem is that articles in Time about Imatinib or in TFA about a PNAS journal article, show the sensationalist nature of health and science reporting. But, you read slashdot so you already know that.

    2. Re:It is wonderful, but it's only in mice by k(wi)r(kipedia) · · Score: 2

      The difference here is the buzz word nano. If the new treatment is a true nano cure, then the difference between this and the old "magical cures" would be the difference between using a drone strike to target the headquarters of a terrorist group versus bombing the village where the headquarters happen to be found.

  5. Re:A cure will never be FDA approved by blackest_k · · Score: 3, Informative

    That is a cynical idea, ok drug companies might prefer long term treatments to cures. But for insurance companies and nationalised health care systems cost is more important.

    luckily the FDA can only rule on drugs for Americans in the USA. In Ireland I got prescribed a drug treatment here that was approved eventually by the FDA. I'm very happy for it being available to me sooner rather than later, and i am sure Americans are now seeing the benefits now they can have it too.

  6. Re:100% ?!?! by TummyX · · Score: 4, Interesting

    Duh. The test on rats so far showed no side-effects which makes it better than radiation or incinerating the rats to kill the virus.

  7. Re:100% ?!?! by SJHillman · · Score: 4, Funny

    But it uses the word "nano" so it must work.

  8. Success Rate by kjshark · · Score: 5, Informative

    The previous treatment with ribavirin and interferon for one year had a 50% success rate. The newer six month treatment with the addition of Incivek for three months has over 75% rate. Since Incivek has only been on the market for about a year, that success rate is not as precise as it will be.

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    1. Re:Success Rate by muridae · · Score: 2

      Depends on the viral genetics. Type 1 is harder to cure, but most prevalent in the USA. Then a specific pattern inside the type (pair of codons in the DNA, either TC, CT, TT, or CC) can make it harder or easier to cure. Type 1 A has something above 50% success rate with the new three drug treatment, I've been told up to 75% after 6 months (as you mentioned) but with the possibility of knowing if it will work after 2. The viral load reduces by at least log2 at 2 months if it is going to respond well. Other genotypes respond much better, with one (i think 3 or 4) having a response rate over 90% to just interferon.

  9. Re:100% ?!?! by Anonymous Coward · · Score: 2, Informative

    I wish people would get that chemistry != nanotechnology.

    Our world is filled with nanoscale molecules, including many that we designed and created, but the word "nanotechnology" was specifically coined to describe building things by the manipulation of individual atoms.

  10. Re:100% ?!?! by Bengie · · Score: 2

    Add "on the internet" and they can patent it with no questions asked.

  11. Next up... by Jahava · · Score: 4, Funny

    Hepatitis C++? Hepatitis C#?

    Objective Hepatitis C. *shudders*

  12. Re:A cure will never be FDA approved by durrr · · Score: 4, Funny

    Dress up like a horse and go to a vet and you can get gene therapy and stem cells treatments.

  13. Re:A cure will never be FDA approved by Darkness404 · · Score: 3, Informative

    Which is why if you really want first class medical treatment you don't get it in the USA. Even routine things such as stitches at the hospital can easily run you $500 without insurance in the US at even a bottom-barrel hospital. Go to Mexico at a top-tier, first class hospital and you can get your hand stitched up for under $50 without insurance.

    Not to mention that nearly every other country (even including those in Europe!) have more access to cutting edge treatments.

    Unfortunately, most Americans won't think to really look abroad because they think that the US is the most advanced nation in the world and that they can really get the best care there.

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  14. Re:100% ?!?! by nitehawk214 · · Score: 2

    I wish people would get that chemistry != nanotechnology.

    Our world is filled with nanoscale molecules, including many that we designed and created, but the word "nanotechnology" was specifically coined to describe building things by the manipulation of individual atoms.

    Unless you count crystals like diamond as one big molecule... I am pretty sure every molecule is nanoscale. Even .

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  15. Re:A cure will never be FDA approved by Anonymous Coward · · Score: 3, Informative

    Same here in Canada. We're taught from an early age that we have the best health care system in the world, and everyone here believes it.

    I'll keep this short, but we had a baby here in Canada and then we had our second child in Mexico, both were Cesarean. The care we received in Mexico was 100 times better than what we got in Canada. No waiting, no crappy attitude from nurses and doctors.. We had complications here in Canada but not in Mexico, and I believe that's due to a better doctor doing a more careful job. Not to mention the hospital was like a 5 star hotel, with a private room, big screen tv, etc.

    You pay for the service there, but it's a real eye opener to realize how crappy our health care system is back home in comparison. So much for 1st world vs 3rd world.

  16. Re:A cure will never be FDA approved by ewieling · · Score: 2

    That is a cynical idea, ok drug companies might prefer long term treatments to cures. But for insurance companies and nationalised health care systems cost is more important.

    Maybe health insurance companies should start buying pharma companies? That might change a few things.

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  17. Re:A cure will never be FDA approved by Dixie_Flatline · · Score: 2

    I read an article that said the worst thing that ever happened to Canadian health care was for us to be situated next to the USA. Our system is leaps and bounds ahead of theirs, but because that's the metric by which we compare everything, we end up with a lousier system than somewhere like Mexico, or what they have in Scandinavia.

    A friend of mine went to Holland to visit family. For her to get an ultrasound booked (because her family can't be back in Canada for the birth) was faster and cheaper in Holland--where she doesn't have insurance--than it would be here. AND when they found out that she was in from Canada, they threw in some freebie scans. Just like that.

    I appreciate our system, I really do. It's taken care of me in some bad accidents, and when my family has had trouble (cancer, old age, heart disease) they've gotten really good care, without the rest of the family worrying about how we're going to live while paying for treatment. But being better than a place that has so many demonstrable, objective deficiencies doesn't make our system the best.